公开(公告)号：US20240363322A1

公开(公告)日：2024-10-31

申请号：US18686595

申请日：2022-08-31

Applicant: Micromass UK Limited

Inventor： Suloke Mathai ,  Ian David Trivett

IPC: H01J49/04 ,  G01N27/623 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/167 ,  G01N27/623

Abstract: A nebuliser outlet assembly comprises an inlet end and an outlet end, and a first channel (24) arranged between the inlet end and the outlet end, wherein the first channel is configured to receive a capillary. The nebuliser outlet assembly comprises a first part (40) and one or more second parts (50), wherein the one or more second parts are removably attachable to the first part. The nebuliser outlet assembly is configured such that the first channel is formed from the first part and the one or more second parts when the one or more second parts are attached to the first part. The first part comprises an open-sided channel that corresponds to the first channel for at least some of its length. The nebuliser outlet assembly is configured such that when the one or more second parts are removed from the first part, said open-sided channel is exposed.

公开(公告)号：US20240234118A9

公开(公告)日：2024-07-11

申请号：US18546528

申请日：2022-02-15

Applicant: Micromass UK Limited

Inventor： Alastair Booth ,  Ian Trivett ,  Anthony Hesse ,  Mark Walford ,  David Gordon ,  Haydn Murray ,  Stephen Aryton

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/0404 ,  H01J49/167

Abstract: A nebuliser comprises an outlet aperture and a liquid capillary. A method of operating the nebuliser comprises supplying a gas to the outlet aperture, measuring a flow rate of the gas supplied to the outlet aperture, and determining a position of the liquid capillary relative to the outlet aperture based on the measured flow rate.

公开(公告)号：US20240222104A1

公开(公告)日：2024-07-04

申请号：US18684195

申请日：2022-08-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Stanislaw POTYRALA ,  Bradley B. SCHNEIDER ,  Leigh BEDFORD

IPC: H01J49/04 ,  H01J49/06 ,  H01J49/16

CPC classification number: H01J49/044 ,  H01J49/045 ,  H01J49/067 ,  H01J49/165

Abstract: A curtain chamber includes an orifice plate defining an orifice plate bore. A curtain plate is disposed adjacent to the orifice plate and defines a curtain plate bore. The orifice plate bore is disposed adjacent the curtain plate bore. A biasing element includes a first portion disposed in the orifice plate bore and a second portion disposed in the curtain plate bore. The biasing element biases the curtain plate towards the orifice plate. A race is defined by at least one of the orifice plate and the curtain plate. The race defines a race depth. A seal is disposed in the race. The seal includes an uncompressed seal depth greater than the race depth and a compressed seal depth less than the uncompressed seal depth.

公开(公告)号：US20230377867A1

公开(公告)日：2023-11-23

申请号：US18031240

申请日：2021-10-11

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas COVEY ,  Peter KOVARIK

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/167

Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a specimen may be received within an open port of a sampling probe and continuously delivered via a jet pump assembly to an ion source for subsequent mass spectrometric analysis.

公开(公告)号：US20230352289A1

公开(公告)日：2023-11-02

申请号：US18137555

申请日：2023-04-21

Applicant: Elemental Scientific, Inc.

Inventor： Cole J. Nardini ,  Austin Schultz ,  Daniel R. Wiederin

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/04

CPC classification number: H01J49/0036 ,  H01J49/105 ,  H01J49/045

Abstract: Systems and methods are described for analyzing local minimum data from spectrometry data for the determination of nanoparticle detection thresholds are described. In aspects, a histogram of the spectrometry data is used to search for potential local minimum values, which are subsequently validated to establish a nanoparticle detection threshold for the spectrometry data, with ion intensity values less than the nanoparticle detection threshold being attributable to signal background.

公开(公告)号：US11699580B2

公开(公告)日：2023-07-11

申请号：US16930388

申请日：2020-07-16

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Guangtao Li ,  Guangming Huang ,  Jason Duncan ,  Xin Li ,  Ewa Sokol ,  Xin Yan

IPC: H01J49/04 ,  H01J49/00 ,  G01N27/62 ,  H01J49/42

CPC classification number: H01J49/04 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/0445 ,  H01J49/4205 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US20190189416A1

公开(公告)日：2019-06-20

申请号：US16146752

申请日：2018-09-28

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Barzagan

IPC: H01J49/10 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/049 ,  H01J49/167

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US09978573B2

公开(公告)日：2018-05-22

申请号：US15552918

申请日：2016-03-15

Applicant: KEIO UNIVERSITY

Inventor： Tomoyoshi Soga ,  Akiyoshi Hirayama ,  Hiroshi Abe

IPC: H01J49/00 ,  H01J49/04 ,  G01N27/447 ,  B01D61/42

CPC classification number: H01J49/045 ,  B01D61/422 ,  G01N27/4473 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/0404 ,  H01J49/165

Abstract: Processing a capillary distal end into acute-angle, an electrophoretic liquid passing hole through which electrophoretic liquid pass is opened in a flexible insulating plate. An electrodialysis-membrane is bonded covering the electrophoretic liquid passing hole; the capillary is securely bonded to the insulating plate portion with no gap therebetween, the portion excluding electrophoretic liquid passing hole on the electrodialysis top-membrane. A crack forms at the capillary portion at the electrophoretic liquid passing hole, with the capillary entirely secured to the insulating plate except portion at the electrophoretic liquid passing hole. The capillary is securely bonded to the insulating plate; reservoir stores electrophoretic liquid on the insulating plate-side to which the capillary is unsecured. An electrode insertion hole into which an electrode is inserted opened in the reservoir upper portion; the electrode is securely inserted into the electrode insertion hole. By this, high-sensitivity measurement is using a spray device for sheathless CE-MS.

公开(公告)号：US20170176401A1

公开(公告)日：2017-06-22

申请号：US15387133

申请日：2016-12-21

Applicant: Micromass UK Limited

Inventor： Stevan BAJIC ,  David S DOUCE ,  Gordon A JONES

IPC: G01N30/72 ,  H01J49/04 ,  B05B17/06 ,  G01N30/06

CPC classification number: G01N30/724 ,  B05B17/0607 ,  B05B17/0623 ,  G01N30/06 ,  G01N2030/8447 ,  G01N2030/8452 ,  G01N2030/8458 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/0454

Abstract: A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.

公开(公告)号：US09673032B1

公开(公告)日：2017-06-06

申请号：US15087312

申请日：2016-03-31

Applicant: Agilent Technologies, Inc.

Inventor： Arthur Schleifer ,  Nigel P. Gore

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/14 ,  H01J49/34

CPC classification number: H01J49/045

Abstract: A sample sprayer includes a first conduit for conducting a liquid sample, a second conduit surrounding the first conduit to define an annular passage for conducting a gas, a sprayer tip in which a fluid interaction region receives the liquid sample and the gas. The sprayer tip is configured to produce a sample spray by contact between the liquid sample and the gas in the fluid interaction region and emit the sample spray from the orifice. An adjustable positioning device is configured to translate the first conduit along the longitudinal axis in response to adjustment of the positioning device, wherein an axial position of the first conduit is adjustable relative to the orifice.