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公开(公告)号：US11351260B2
公开(公告)日：2022-06-07
申请号：US16869896
申请日：2020-05-08
Inventor： Jaeheung Cho , Daeha Seo , Jisu Choe
Abstract: The present invention relates to a cobalt-nitrosyl complex having photocleavable ligands. The cobalt-nitrosyl complex provided in one aspect of the present invention is adept in the delivery of NO, with exquisite temporal control using light, without gene editing. In addition, the complex provided in one aspect of the present invention is excellent in biocompatibility because it is chemically stable, non-toxic at cell level, and non-perturbative in cellular environments.
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公开(公告)号：US20220133259A1
公开(公告)日：2022-05-05
申请号：US17516850
申请日：2021-11-02
Inventor： Jae Youn HWANG , Moon Hwan LEE , Hah Min LEW
Abstract: Disclosed are a bladder monitoring apparatus which accurately determines a bladder status of a subject based on an ultrasonic image and a posture of the subject and a method for controlling the bladder monitoring apparatus. The bladder monitoring apparatus includes a processor, a memory configured to operably connected to the processor and store at least one code executed by the processor, and a transceiver configured to receive a reflection ultrasonic signal from a subject and a posture sensing signal obtained by sensing a posture of the subject based on a sensor, and the memory may store a code which is executed by the processor to cause the processor to determine the bladder status of the subject by applying the machine learning-based learning model to an ultrasonic image generated from the reflection ultrasonic signal and posture information generated based on the posture sensing signal.
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公开(公告)号：US20220120624A1
公开(公告)日：2022-04-21
申请号：US17427775
申请日：2019-07-23
Inventor： June Seo KIM , Myoung Jae LEE , Hyeon Jun LEE
Abstract: Disclosed is a force sensor. More particularly, the force sensor includes a first permanent magnet layer; a magnetic tunnel junction disposed on the first permanent magnet layer and configured to have a preset resistance value; and a second permanent magnet layer disposed to be spaced apart from the magnetic tunnel junction, wherein the second permanent magnet layer moves in a direction of the first permanent magnet layer when pressure is applied from outside, the preset resistance value of the magnetic tunnel junction is changed when a magnetic field strength formed between the first permanent magnet layer and the second permanent magnet layer becomes a preset strength or more according to movement of the second permanent magnet layer, and the force sensor senses the pressure based on a change in the preset resistance value.
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公开(公告)号：US20220063088A1
公开(公告)日：2022-03-03
申请号：US17370148
申请日：2021-07-08
Inventor： Hee Don LEE , Tae Hun KANG
Abstract: A series elastic actuator includes a first body, a motor, a pulley, a second body, a wire, a first adjuster, a second adjuster, a first spring, and a second spring. The wire is curved around a seat portion of the pulley, a first extending portion of the wire and the first adjuster are elastically supported with respect to the second body by the first spring, and the second extending portion of the wire and the second adjuster are elastically supported with respect to the second body by the second spring. When an external load is applied to the second body and relative rotation is generated between the pulley and the second body, a moment arm by the load is constant and the external load can be measured on the basis of the measured relative rotation angle and the spring constants of the first spring and the second spring.
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公开(公告)号：US20210371484A1
公开(公告)日：2021-12-02
申请号：US17330479
申请日：2021-05-26
Inventor： So Yeon KIM , Che Il MOON
IPC: C07K14/505 , A61P25/28
Abstract: Peptides are easy to pass through a tissue-blood barrier, have excellent physiological activity in the protective activity of cells, and have an economic advantage due to low production costs. In addition, since there is no side effect of cell proliferation, a pharmaceutical composition containing a peptide of an aspect as an active ingredient can be usefully used in the treatment or prevention of neurological disorders and degenerative brain diseases.
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Patent Agency Ranking
公开(公告)号：US20210348108A1
公开(公告)日：2021-11-11
申请号：US17284108
申请日：2019-10-07
Inventor： Hong Soo CHOI , EunJung SHIN , Hong Goo YEO , Eun Hee KIM
Abstract: A cell stimulation apparatus according to an embodiment of the present invention includes: an electrode unit in which an electrode element is installed; a pMUT element disposed above the electrode unit to be spaced apart from the electrode unit, and configured to generate an ultrasonic wave through a voltage applied thereto; and a well element installed between the electrode unit and the pMUT element and forming a cell chamber together with the electrode unit and the pMUT element, wherein a bio-sample is disposed on the electrode element, and the ultrasonic wave generated by the pMUT element is transmitted to the bio-sample so as to provide ultrasound stimulation to the bio-sample.
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公开(公告)号：US20210302284A1
公开(公告)日：2021-09-30
申请号：US17207890
申请日：2021-03-22
Inventor： Min Seok KIM
IPC: G01N1/30 , G01N1/31 , C12N11/087
Abstract: The present disclosure relates to a method and apparatus for cell staining without cell loss, and more particularly, to a method and apparatus for cell staining without cell loss during treatment of a staining reagent or washing reagent by immobilizing cells to be analyzed in a phase change material before staining. A method for cell staining without cell loss according to the present disclosure may effectively prevent cell loss during staining and analysis of rare cells that are becoming important in clinical diagnosis, and thus may facilitate observation, analysis and diagnosis thereby even with a trace amount of sample. In addition, as the method for cell staining without cell loss according to the present disclosure allows immobilization of cells, it makes discrimination and isolation of single cells easy, and may be effectively used in analysis of the isolated cells.
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公开(公告)号：US11107187B2
公开(公告)日：2021-08-31
申请号：US16541628
申请日：2019-08-15
Inventor： Min Soo Kim , Himchan Park
IPC: G06T3/40 , G06T1/20 , G06F16/901
Abstract: A graph upscaling method and apparatus is disclosed. The graph upscaling apparatus may store, in a main memory, original graph data including topological data including a vertex and an edge, determine a parent edge using a hash function and the original graph data, and generate a new edge based on the determined parent edge. The graph upscaling apparatus may store, in a main memory, original graph data including topological data including a vertex and an edge, allocate identities (IDs) of edges to be generated to cores included in a central processing unit (CPU) based on the number of the cores, and generate new edges based on the IDs of the edges using a hash function and the original graph data.
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公开(公告)号：US11058895B2
公开(公告)日：2021-07-13
申请号：US16103033
申请日：2018-08-14
Inventor： Pyung Hun Chang , Erkin Gezgin
Abstract: Provided is a collimator including a base unit configured to form a radiation path of light; a pair of first moving members rotatably installed in the base unit; a pair of second moving members movably installed in the base unit; and an actuator configured to externally receive power and transmit the power to the first moving members and the second moving members, wherein a first space may be formed between the first moving members, a second space may be formed between the second moving members, and the light may pass through a radiation area corresponding to an overlapping area of the first space and the second space.
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公开(公告)号：US20210206821A1
公开(公告)日：2021-07-08
申请号：US17059513
申请日：2019-06-24
Inventor： Kyung Moo YEA , Min Seok KIM
IPC: C07K14/52 , C07K14/705 , C12N15/86
Abstract: The present invention relates to a cytokine fusion polypeptide or a cytokine library comprising the same, and according to the cytokine fusion polypeptide or a cytokine library comprising the same according to an aspect, it enables continuous stimulation by a cytokine to a target cell and thus can easily and accurately evaluate the functionality of cytokines at the single cell level.
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