公开(公告)号：US20240002442A1

公开(公告)日：2024-01-04

申请号：US18254459

申请日：2021-11-24

Applicant: Northeastern University

Inventor： Kim Lewis ,  Ryan Miller ,  Akira Iinishi ,  Patrick James Lariviere ,  Thomas Curtis

IPC: C07K7/64 ,  A01N63/50 ,  A01P1/00

CPC classification number: C07K7/64 ,  A01N63/50 ,  A01P1/00 ,  A61K38/00

Abstract: Novel compounds and analogues that exhibit antimicrobial activity—particularly against Gram-negative pathogens—are producible from bacterial isolate Photorhabdus australis DSM 17609 and some related bacterial species of the genus. Pharmaceutical compositions containing the novel compound and its analogues are useful for treating or preventing a bacterial infection. Compounds in accordance herewith include ribosomally produced and post-translationally modified cyclic peptides useful for the treatment, amelioration, and prevention of bacterial infections by Gram-negative pathogens, in addition to other indications.

公开(公告)号：US11852615B2

公开(公告)日：2023-12-26

申请号：US17920553

申请日：2019-09-18

Applicant: Northeastern University

Inventor： Xiating Feng ,  Xiaojun Yu ,  Jun Tian

IPC: G01N3/12 ,  G01N3/06

CPC classification number: G01N3/12 ,  G01N3/066 ,  G01N2203/0256

Abstract: The invention relates to a one-way rapid electromagnetic unloading device suitable for a true triaxial testing machine, comprising a first electromagnet, a second electromagnet, a first electromagnet mounting base, a second electromagnet mounting base and a restraining disc. A frame of the true triaxial testing machine is provided with a mounting hole for the unloading device. The first electromagnet mounting base is fixedly mounted in the mounting hole for the unloading device, and the first electromagnet is fixedly mounted on the first electromagnet mounting base. The restraining disc is fixedly mounted at an opening of the mounting hole for the unloading device, and the second electromagnet mounting base is located between the restraining disc and the first electromagnet. The second electromagnet is fixedly mounted on the second electromagnet mounting base and is opposite to the first electromagnet.

公开(公告)号：US20230409951A1

公开(公告)日：2023-12-21

申请号：US18250648

申请日：2021-11-23

Applicant: Northeastern University ,  Academia Sinica ,  Temple University-Of The Commonwealth System Of Higher Education

Inventor： Jeng-Yuan Tsai ,  Jinbo Pan ,  Hsin Lin ,  Arun Bansil ,  Qimin Yan

IPC: G06N10/40 ,  G06N10/20 ,  H01L29/66

CPC classification number: G06N10/40 ,  G06N10/20 ,  H01L29/66977 ,  H01L29/66984

Abstract: Anion antisite defects in monolayer Transition Metal Dichalcogenide (TMD) systems are here identified as two-dimen-sional solid-state defect qubits. The proposed antisites in these TMDs host paramagnetic triplet ground states with flexible level splitting. A viable transition loop between the triplet and singlet defect states is demonstrated, including optical excitations/relaxations and nonradiative decay paths for the antisites as qubits. A complete set of qubit operational processes, including initialization, manipulation, and readout, is delineated.

公开(公告)号：US20230408533A1

公开(公告)日：2023-12-21

申请号：US18112203

申请日：2023-02-21

Applicant: Northeastern University

Inventor： Yunrong CHAI ,  Yuxuan Qin ,  Nicole Taylor Cavanaugh

IPC: G01N33/94 ,  G01N21/78 ,  C12N9/04 ,  C12N9/02

CPC classification number: G01N33/9406 ,  G01N21/78 ,  C12N9/0006 ,  C12Y101/01061 ,  C12N9/0051 ,  C12Y108/01004 ,  G01N2021/7759

Abstract: Disclosed are compositions and methods for detecting the presence or level of gamma-hydroxybutyric acid (GHB), or for diagnosing GHB toxicity or overdose.

公开(公告)号：US20230392106A1

公开(公告)日：2023-12-07

申请号：US18448031

申请日：2023-08-10

Applicant: Northeastern University

Inventor： Shashi K. Murthy

IPC: C12M1/36 ,  C12M1/42 ,  C12N5/0784 ,  A61K39/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/02 ,  C12M1/26

CPC classification number: C12M41/48 ,  C12M35/08 ,  C12N5/0639 ,  A61K39/0008 ,  C12M23/16 ,  C12M23/28 ,  C12M27/00 ,  C12M29/04 ,  C12M33/00 ,  C12M41/14 ,  C12N2501/22 ,  C12N2501/25 ,  C12N2501/2306

Abstract: Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood, and the automated generation of immunotherapeutic products from those dendritic cells, all within a closed system. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.

公开(公告)号：US20230348358A1

公开(公告)日：2023-11-02

申请号：US18020451

申请日：2021-08-19

Applicant: Northeastern University

Inventor： Raymond BOOTH

IPC: C07C211/42 ,  C07D217/02 ,  C07D307/52 ,  C07D207/335 ,  C07D295/073 ,  A61P25/08

CPC classification number: C07C211/42 ,  C07D217/02 ,  C07D307/52 ,  C07D207/335 ,  C07D295/073 ,  A61P25/08 ,  C07B2200/07 ,  C07C2602/10 ,  C07C2601/08

Abstract: Compounds, compositions, and methods are provided for dual partial agonism of serotonin 5-HTS and 5-HTIA receptors. The enantiomerically pure 5-phenyl-2-aminotetralin (5-PAT) compounds can be used to treat or prevent substance use disorder, opioid use disorder, addiction, anxiety, psychosis, depression, autism spectrum disorder, fragile X syndrome, neurological disorders, neuropsychiatric disorders, repetitive behaviors, movement disorders, compulsions, tics, pain disorders, vasospastic disorders, migraine headache, seizures, epilepsy, social anxiety, addiction withdrawal, drug withdrawal, drug abuse, alcoholism, eating disorders, general inflammation disorders, miosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and gastrointestinal disorders.

公开(公告)号：US20230348197A1

公开(公告)日：2023-11-02

申请号：US17640035

申请日：2021-07-21

Applicant: Northeastern University

Inventor： Xin SHA ,  Lin FENG ,  Yingwei ZHANG

IPC: B65G43/00 ,  G06F17/11

CPC classification number: B65G43/00 ,  G06F17/11

Abstract: Provided is a sound-based roller fault detecting method by using double-projection neighborhoods preserving embedding, including: acquiring sound data during operation of a roller, performing a wavelet transform energy feature extraction on normal data in the data to obtain wavelet transform energy feature data, then performing double-projection neighborhoods preserving embedding feature extraction on the wavelet energy feature data to obtain an optimal projection matrix of the feature data, establishing a detection model, constructing T2 statistics of a feature space and a residual space of normal sound data, determining detection control limits according to the T2 statistics by a kernel density estimation method, and further judging whether newly acquired data has faults. According to the present method, main features of the data can be extracted under the conditions of non-dimensional reduction and dimensionnal reduction, and thus the present method can achieve the purpose of increasing fault detection accuracy.

公开(公告)号：US20230332082A1

公开(公告)日：2023-10-19

申请号：US18134522

申请日：2023-04-13

Applicant: Northeastern University

Inventor： Slava EPSTEIN ,  Yongchao YIN

IPC: C12M1/12 ,  C12Q1/689 ,  C12Q1/6869

CPC classification number: C12M25/04 ,  C12Q1/689 ,  C12Q1/6869

Abstract: High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes and a membrane support layer that aids in membrane removal for access to growth chambers without contamination. The devices are placed in natural environments for cultivation of unknown microbial species.

公开(公告)号：US11773720B2

公开(公告)日：2023-10-03

申请号：US18023481

申请日：2021-04-01

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Xiating Feng ,  Feng Lin ,  Chengxiang Yang ,  Jiuyu Zhang ,  Xiangxin Su ,  Shiping Li

IPC: E21C37/00 ,  E21C41/22 ,  C22B4/08 ,  E21F15/00 ,  E21B1/00

CPC classification number: E21C3/00 ,  C22B4/08 ,  E21C41/22 ,  E21F15/00

Abstract: A microwave-mechanical fluidization mining system and a mining method for metal mines. The microwave-mechanical fluidization mining system comprises a microwave pre-splitting mechanical mining system, a microwave separation system, a high-power microwave focused melting system and a goaf, wherein ore-waste rock mixtures mined by the microwave pre-splitting mechanical mining system are transported to the microwave separation system through a conveyor and an elevator on the microwave pre-splitting mechanical mining system, separated ores are transported to the high-power microwave focused melting system, and separated waste rocks are transported through a conveyor to the goaf for filling. Microwave pre-splitting mechanical mining is adopted instead of a traditional blasting mining method to increase an excavation speed and avoid the influence of blasting on the stability of surrounding rocks.

公开(公告)号：US11768252B2

公开(公告)日：2023-09-26

申请号：US17698835

申请日：2022-03-18

Applicant: MERSEN USA EP CORP. ,  Northeastern University

Inventor： Roy A. Ball ,  Jonathan C. Kim ,  Bradley M. Lehman

IPC: G01R31/40 ,  G01R31/52 ,  H02J3/38

CPC classification number: G01R31/40 ,  G01R31/52 ,  H02J3/381 ,  H02J2300/24

Abstract: Pink noise analysis, along with unique properties of the photovoltaic (PV) operating point of both the instantaneous current and voltage signal, is used to distinguish arc faults from other noisy loads or PV degradations.