公开(公告)号：US20150173657A1

公开(公告)日：2015-06-25

申请号：US14629171

申请日：2015-02-23

Applicant: Abbott Diabetes Care Inc.

Inventor： Udo Hoss ,  Benjamin J. Feldman ,  Zenghe Liu ,  Hyun Cho ,  Benjamin M. Rush

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0252 ,  A61B2560/0443

Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.

Abstract translation: 用于确定实时分析物浓度的方法和系统，包括分析物传感器，所述分析物传感器具有与皮肤层下面的间质液体流体接触的部分;体内电子器件，包括耦合到分析物传感器并被配置用于定位在皮肤层上的壳体， 在壳体上包括多个电触头的体内电子壳体; 以及数据分析单元，具有在壳体上的数据分析单元外壳和多个探针。 每个探针被配置为当数据分析单元与体内电子器件物理接触地定位时电耦合到相应的电接触。 探针上的一个或多个信号对应于基本上实时监测的分析物浓度水平（MACL），预定时间段内的MACL或MACL的变化率或其组合中的一个或多个。

公开(公告)号：US20140054171A1

公开(公告)日：2014-02-27

申请号：US13767350

申请日：2013-02-14

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Lam N. Tran ,  Zenghe Liu ,  Yi Wang

IPC: G01N27/327

CPC classification number: G01N27/3272

Abstract: An analyte sensor configured to utilize oxygen as an oxidant and method for manufacturing and using the same are provided. The analyte sensor includes a catalyst to facilitate use of oxygen as oxidant. The catalyst may be provided on an electrode of the analyte sensor.

Abstract translation: 提供了构造成利用氧气作为氧化剂的分析物传感器及其制造和使用方法。 分析物传感器包括促进使用氧气作为氧化剂的催化剂。 催化剂可以设置在分析物传感器的电极上。

公开(公告)号：US20130184546A1

公开(公告)日：2013-07-18

申请号：US13737671

申请日：2013-01-09

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Zenghe Liu ,  Benjamin J. Feldman ,  Brian Cho

IPC: A61B5/1495 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/742 ,  A61B5/746 ,  G01N33/48771

Abstract: Generally, embodiments of the invention relate to analyte determining devices (e.g., electrochemical analyte monitoring systems) that include an indicator element that provides information relating to service history of the analyte determining devices, including, for example, previous use of the analyte determining devices. Also provided are systems and methods of using the, for example electrochemical, analyte determining devices in analyte monitoring.

公开(公告)号：US20240328989A1

公开(公告)日：2024-10-03

申请号：US18407099

申请日：2024-01-08

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Jonathan D. McCanless ,  Tianmei Ouyang ,  Stephen M. Oja ,  Yagya Raj Ojha ,  Rifat Emrah Ozel ,  Cade B. Fox ,  Zenghe Liu ,  Benjamin J. Feldman

IPC: G01N27/327 ,  C08L39/08 ,  C08L75/04

CPC classification number: G01N27/3277 ,  C08L39/08 ,  C08L75/04 ,  C08L2203/206

Abstract: The present disclosure provides an analyte sensor comprising a working electrode, a sensing layer disposed on at least a portion of the working electrode, and a hydrophilic polyurethane membrane overcoating at least the sensing layer, wherein the hydrophilic polyurethane is aliphatic, aromatic, or both aliphatic and aromatic. The hydrophilic polyurethane membrane limits the transport of mass to the sensing layer without the need to be crosslinked. With such membrane, the analyte sensor can provide consistent analyte measurements over a temperature range of about 22-42° C. The present disclosure is further related to a method of forming an analyte sensor comprising providing a working electrode, disposing a sensing layer on at least a portion of the working electrode, and coating at least the sensing layer with a hydrophilic polyurethane membrane, wherein the hydrophilic polyurethane is aliphatic, aromatic, or both aliphatic and aromatic.

公开(公告)号：US20240324913A1

公开(公告)日：2024-10-03

申请号：US18621449

申请日：2024-03-29

Applicant: Abbott Diabetes Care, Inc.

Inventor： Zenghe Liu ,  Tram Nguyen ,  Benjamin Feldman

IPC: A61B5/145 ,  G01N27/327

CPC classification number: A61B5/14546 ,  G01N27/3271 ,  G01N27/3277

Abstract: The present invention relates to analyte sensors for use in detecting the concentration of potassium ions in a biological fluid and methods of using the sensors.

公开(公告)号：US20220330856A1

公开(公告)日：2022-10-20

申请号：US17532755

申请日：2021-11-22

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Martin J. Fennell ,  Jean-Pierre Cole ,  Theodore John Kunich ,  Udo Hoss ,  Benjamin Jay Feldman ,  Zenghe Liu

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486

Abstract: Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.

公开(公告)号：US11439326B2

公开(公告)日：2022-09-13

申请号：US16252994

申请日：2019-01-21

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Zenghe Liu ,  Hyun Cho ,  Benjamin J. Feldman

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/00

Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.

公开(公告)号：US09895091B2

公开(公告)日：2018-02-20

申请号：US14719836

申请日：2015-05-22

Applicant: Abbott Diabetes Care Inc.

Inventor： Zenghe Liu ,  Benjamin J. Feldman ,  Hyun Cho ,  Udo Hoss

IPC: A61B5/1486 ,  C12Q1/00 ,  G01N27/30 ,  A61B5/145 ,  G01N27/327

CPC classification number: A61B5/1486 ,  A61B5/14532 ,  C12Q1/006 ,  G01N27/301 ,  G01N27/3272

Abstract: The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.

公开(公告)号：US09775544B2

公开(公告)日：2017-10-03

申请号：US15347607

申请日：2016-11-09

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Zenghe Liu ,  Yohannes Goti ,  Benjamin J. Feldman ,  Udo Hoss

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/172 ,  A61L31/04 ,  A61L31/06

CPC classification number: A61B5/14532 ,  A61B5/1468 ,  A61B5/14865 ,  A61B2560/0223 ,  A61L31/047 ,  A61L31/048 ,  A61L31/06 ,  A61M5/1723 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2230/005 ,  A61M2230/201

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

公开(公告)号：US09428785B2

公开(公告)日：2016-08-30

申请号：US14558509

申请日：2014-12-02

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Tianmei Ouyang ,  Zenghe Liu

IPC: G01N27/327 ,  C12Q1/00 ,  A61B5/145 ,  C12Q1/32

CPC classification number: C12Q1/006 ,  A61K38/28 ,  C12Q1/004 ,  C12Q1/005 ,  C12Q1/32 ,  G01N27/3272 ,  G01N27/3273 ,  G01N2333/904

Abstract: Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring.

Abstract translation: 本发明的实施方案包括分析物响应组合物和电化学分析物传感器，其具有包含分析物响应酶和阳离子聚合物的感测层。 还提供了制造传感器并在分析物监测中使用电化学分析物传感器的系统和方法。