公开(公告)号：US20220202327A1

公开(公告)日：2022-06-30

申请号：US17567651

申请日：2022-01-03

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Zenghe Liu ,  Benjamin J. Feldman

IPC: A61B5/1486 ,  A61B5/145 ,  C12N9/04

Abstract: The present disclosure provides an analyte sensor for use in detecting various analytes. In certain embodiments, an analyte-responsive active area of a presently disclosed analyte sensor includes two or more enzyme systems for detecting the analyte. The present disclosure further provides methods for detecting various analytes using the disclosed analyte sensors.

公开(公告)号：US20220186278A1

公开(公告)日：2022-06-16

申请号：US17548487

申请日：2021-12-10

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Zenghe Liu ,  Stephen Oja ,  Tianmei Ouyang ,  Benjamin J. Feldman

IPC: C12Q1/00 ,  G01N33/64

Abstract: The present disclosure provides an analyte sensor for use in detecting ketones. In certain embodiments, a ketones-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising β-hydroxybutyrate dehydrogenase and NADH oxidase disposed on a surface of a platinum working electrode. The present disclosure further provides methods for detecting ketones using the disclosed analyte sensors.

公开(公告)号：US10285632B2

公开(公告)日：2019-05-14

申请号：US15659480

申请日：2017-07-25

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Udo Hoss ,  Benjamin J. Feldman ,  Zenghe Liu ,  Hyun Cho ,  Benjamin M. Rush

IPC: A61B5/1473 ,  A61B5/1468 ,  A61B5/145 ,  A61B5/00

Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.

公开(公告)号：US10219728B2

公开(公告)日：2019-03-05

申请号：US14445750

申请日：2014-07-29

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Zenghe Liu ,  Hyun Cho ,  Benjamin J. Feldman

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/00

Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.

公开(公告)号：US20170319110A1

公开(公告)日：2017-11-09

申请号：US15659480

申请日：2017-07-25

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Udo Hoss ,  Benjamin J. Feldman ,  Zenghe Liu ,  Hyun Cho ,  Benjamin M. Rush

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1468

CPC classification number: A61B5/1473 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0252 ,  A61B2560/0443

Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts , on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes , on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.

公开(公告)号：US20170188904A1

公开(公告)日：2017-07-06

申请号：US15351162

申请日：2016-11-14

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Zenghe Liu ,  Tianmei Ouyang

IPC: A61B5/1486 ,  C12Q1/00 ,  A61B5/145 ,  G01N27/327 ,  A61B5/00 ,  A61B90/98

CPC classification number: A61B5/1486 ,  A61B5/0004 ,  A61B5/14532 ,  A61B5/6849 ,  A61B90/98 ,  C12Q1/005 ,  C12Q1/006 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/4035

Abstract: Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

公开(公告)号：US20170138886A1

公开(公告)日：2017-05-18

申请号：US15360120

申请日：2016-11-23

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Zenghe Liu ,  Tianmei Ouyang ,  Suyue Qian

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/327

Abstract: Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.

公开(公告)号：US20150230739A1

公开(公告)日：2015-08-20

申请号：US14705881

申请日：2015-05-06

Applicant: Abbott Diabetes Care Inc.

Inventor： Udo Hoss ,  Zenghe Liu ,  Benjamin Jay Feldman

IPC: A61B5/1477 ,  A61B5/00 ,  A61B5/145 ,  A61B5/01 ,  G01N27/327 ,  G01N27/403

CPC classification number: A61B5/1477 ,  A61B5/0002 ,  A61B5/0008 ,  A61B5/01 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6843 ,  A61B2560/0276 ,  G01N27/327 ,  G01N27/4035

Abstract: An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided.

公开(公告)号：US20140026646A1

公开(公告)日：2014-01-30

申请号：US13949996

申请日：2013-07-24

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Zenghe Liu ,  Tianmei Ouyang ,  Suyue Qian

IPC: G01N27/327

CPC classification number: G01N27/3272 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/327

Abstract: Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.

Abstract translation: 提供了用于确定样品流体中分析物的浓度的传感器。 在某些实施例中，传感器包括导电颗粒并且表现出改进的一个或多个感测化学组分分布均匀性，增加的有效工作电极表面积，和/或减少干扰组分进入传感器的样品室。 还提供了使用和制造传感器的方法。

公开(公告)号：US20220186277A1

公开(公告)日：2022-06-16

申请号：US17552103

申请日：2021-12-15

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Tianmei Ouyang ,  Cade Fox ,  Zenghe Liu ,  Stephen Oja ,  Benjamin J. Feldman

IPC: C12Q1/00 ,  C12Q1/32

Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.