公开(公告)号：US20170321813A1

公开(公告)日：2017-11-09

申请号：US15533759

申请日：2015-12-10

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Bjorn Markus Olovsson ,  Christer Olof Eriksson

IPC: F16K11/083 ,  G01N30/20 ,  F16K31/04

CPC classification number: F16K11/0836 ,  B01D15/14 ,  B01D2201/165 ,  F16K5/08 ,  F16K11/02 ,  F16K11/0743 ,  F16K11/083 ,  F16K31/041 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/5762 ,  Y10T137/86533 ,  Y10T137/86549 ,  Y10T137/87442

Abstract: A rotary valve 1 comprising a stator 3 and a rotor 5, wherein the stator comprises a plurality of connection ports (17a-17l) and orifices (19a-19l) and the rotor comprises a plurality of pairs of rotor valve orifices (23a-23h) joined by transfer channels (25a-25d). The rotor is able to be placed in different working positions whereby fluids can be fed to, for example, chromatography columns and/or can be bypassed through or around the valve. The invention also relates to a system comprising two components such as chromatography columns and a rotary valve.

公开(公告)号：US20170173496A1

公开(公告)日：2017-06-22

申请号：US15400473

申请日：2017-01-06

Applicant: Mark A. Stone

Inventor： Mark A. Stone

IPC: B01D15/14 ,  B01D15/30 ,  B01D15/32 ,  G01N30/16 ,  B01D15/40

CPC classification number: B01D15/14 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  G01N30/16 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/387

Abstract: Low-retention pre-columns that allow increased injection volumes of solvents chromatographically stronger than the mobile phase and use of solvents with limited solubility in the mobile phase, such as ethyl acetate and MTBE. The system and method also reduces band broadening due to the extra-column effects acting upstream of the analytical column, including band broadening due to the injection process and due to the connecting tubing and fittings between the injection system and the column. A pre-column may also be used as a guard column, thereby minimizing band broadening due to the guard column.

公开(公告)号：US09496125B2

公开(公告)日：2016-11-15

申请号：US12919570

申请日：2009-03-03

Applicant: Bernard Bunner ,  Geoff C. Gerhardt ,  Joseph A. Jarrell

Inventor： Bernard Bunner ,  Geoff C. Gerhardt ,  Joseph A. Jarrell

IPC: H01J49/00 ,  H01J49/16 ,  B01L3/00 ,  B03C5/02 ,  G01N30/06 ,  G01N30/20 ,  B01L3/02

CPC classification number: H01J49/167 ,  B01L3/0268 ,  B01L3/502792 ,  B01L2200/026 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0427 ,  B03C5/024 ,  B03C2201/26 ,  G01N30/06 ,  G01N30/20 ,  G01N2030/201

Abstract: Described are techniques for use in connection with analyzing a droplet. One or more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument.

Abstract translation: 描述了与分析液滴有关的技术。 在数字微流体装置的表面上形成一个或多个样品液滴。 操纵液滴以使用所述一个或多个液滴产生一个或多个所产生的液滴进行处理。 所产生的一个或多个液滴可以从微流体装置转移到另一装置用于分析。 一个或多个液滴也可以从另一个装置或分析仪器提供给数字微流体装置。

公开(公告)号：US20160313289A1

公开(公告)日：2016-10-27

申请号：US15104069

申请日：2014-12-15

Applicant: GE Healthcare Bio-Science AB

Inventor： Bjorn Olovsson ,  Thomas Arctaedius

IPC: G01N30/20 ,  G01N30/46 ,  F16K11/078 ,  F16K11/076

CPC classification number: G01N30/20 ,  B01D15/1821 ,  F16K11/0743 ,  F16K11/076 ,  F16K11/078 ,  G01N30/466 ,  G01N30/467 ,  G01N30/468 ,  G01N2030/201 ,  G01N2030/202

Abstract: A rotary valve comprising a stator and a rotor, wherein the stator comprises at least three primary connection ports and at least three secondary connection ports, and wherein rotor interconnection paths are arranged to in the different rotor positions interconnect the primary connection ports with the secondary connection ports such that all of at least three secondary connection ports can be connected one at the time to each of at least three primary connection port by rotating the rotor into the different rotor positions. A chromatography system comprising at least three chromatography columns and a column inlet rotary valve, a column outlet rotary valve and a feed recirculation flow path.

Abstract translation: 一种包括定子和转子的旋转阀，其中所述定子包括至少三个主连接端口和至少三个次连接端口，并且其中转子互连路径被布置成在不同的转子位置中将所述主连接端口与所述次级连接 端口，使得通过将转子旋转到不同的转子位置，所有至少三个二次连接端口可以一次连接到至少三个主要连接端口中的每一个。 包括至少三个色谱柱和柱入口旋转阀，柱出口旋转阀和进料再循环流动路径的色谱系统。

公开(公告)号：US09310342B2

公开(公告)日：2016-04-12

申请号：US13122602

申请日：2009-10-06

Applicant: Toshikatsu Sakai ,  Akira Sezaki ,  Takeshi Takagi ,  Takuya Yotani ,  Makoto Takahara ,  Takayuki Oka

Inventor： Toshikatsu Sakai ,  Akira Sezaki ,  Takeshi Takagi ,  Takuya Yotani ,  Makoto Takahara ,  Takayuki Oka

IPC: G01N30/24 ,  G01N30/26 ,  G01N30/20 ,  G01N30/88 ,  B01D15/16 ,  G01N30/74

CPC classification number: G01N30/24 ,  B01D15/16 ,  G01N30/26 ,  G01N30/34 ,  G01N30/74 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/8822

Abstract: A liquid chromatography apparatus is provided with a sample preparation unit, a column that separates components of a sample, an eluent supplier that includes a feeder for supplying eluents to the column, a flow path directional valve capable of introducing fixed amounts of the sample and the eluents to the column, an analyzer for analyzing a test solution composed of the sample components separated by the column and one of the eluents, and a controller, wherein the eluent supplier supplies the eluents to the flow path directional valve in an unmixed state. As a result of employing this configuration, analysis time is shortened and eluent consumption is reduced.

Abstract translation: 液相色谱装置具有样品制备单元，分离样品组分的柱，包括用于向柱供给洗脱液的供给器的洗脱液供给器，能够引入固定量的样品的流路切换阀和 用于分析由柱分离的样品组分和洗脱液之一组成的测试溶液的分析器和控制器，其中洗脱剂供体以未混合的状态将洗脱液供应到流路换向阀。 由于采用这种结构，分析时间缩短，洗脱液消耗减少。

公开(公告)号：US20160061788A1

公开(公告)日：2016-03-03

申请号：US14786397

申请日：2014-04-22

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Takuya Yotani ,  Hiroaki Taira ,  Takayuki Oka ,  Hideki Muraki

IPC: G01N30/20 ,  G01N33/49

CPC classification number: G01N30/20 ,  G01N33/491 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: A switching valve includes: (A) a rotor including: (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including: (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator satisfying the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port.

Abstract translation: 一种切换阀，包括：（A）转子，包括：（1）中心管连接口，（2）与中心管连接口连通的第一阀门流路，（3）弧形第二 阀门流路; （B）定子，包括：（4）第一管连接端口组，当所述转子转动时，所述第一管连接端口组经由所述第一阀内流路与所述中心管连接口独立连通，以及（5）第二管连接 端子组，当转子旋转时，通过第二入口流路相互连通; 和（C）转子和定子的布置满足以下关系：根据第二管连接端口组之间的通过第二管路连通口组的通信状态或非连通状态根据第 第一个管道连接端口组和中心管道连接端口。

公开(公告)号：US20160054274A1

公开(公告)日：2016-02-25

申请号：US14824431

申请日：2015-08-12

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Mark W. Moeller ,  Peyton C. Beals

IPC: G01N30/20

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio.

Abstract translation: 描述了在液相色谱系统中在注射位置稀释样品的方法和系统。 该方法包括将样品装载到第一流体通道中，将流动相的流分离成第一流体通道中的第一流量，以及在第二流体通道中的第二流量，以及将从第一流体通道 以及在注入系统流程的位置处离开第二流体通道的流动相，从而在系统流中产生稀释的样品。 稀释样品的稀释比对第一和第二流量的流量有反应。 有利地，可以通过改变流体通道之一的流量限制来改变流量。 因此，提供适当的流量限制使得用户能够获得期望的稀释比。

公开(公告)号：US20150121996A1

公开(公告)日：2015-05-07

申请号：US14593207

申请日：2015-01-09

Applicant: Alltech Associates, Inc.

Inventor： Raaidah Saari-Nordhaus ,  Washington Mendoza ,  Josef Bystron ,  Neil Picha ,  Bruce Black

IPC: G01N30/24 ,  G01N30/20

CPC classification number: G01N30/24 ,  G01N30/20 ,  G01N35/00732 ,  G01N2030/201 ,  G01N2035/0493 ,  Y10T29/49826 ,  Y10T137/86493

Abstract: Automated sample injection apparatus, multiport valves, and chromatography systems containing an automated sample injection apparatus and/or a multiport valve are disclosed. Methods of making and using automated sample injection apparatus and multiport valves within chromatography systems are also disclosed.

Abstract translation: 公开了包含自动化样品注射装置和/或多端口阀的自动注射装置，多端口阀和色谱系统。 还公开了在色谱系统内制造和使用自动化样品注射装置和多端口阀的方法。

公开(公告)号：US20150047422A1

公开(公告)日：2015-02-19

申请号：US14383239

申请日：2013-03-05

Applicant: Waters Technologies Corporation

Inventor： Emily J. Berg ,  Joshua A. Shreve ,  James E. Usowicz ,  Douglas P. Wittmer ,  Aaron Lebeau

IPC: B01D15/14 ,  G01N30/28 ,  B01D15/40

CPC classification number: B01D15/14 ,  B01D15/40 ,  G01N30/16 ,  G01N30/20 ,  G01N30/28 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N30/32

Abstract: A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection.

Abstract translation: 超临界流体色谱系统设置有用于将样品引入流动相流体流的注射阀子系统。 喷射阀子系统包括辅助阀和喷射阀。 辅助和注入阀的操作以减少样品注入期间发生的样品携带和系统压力扰动的方式进行协调。

公开(公告)号：US08931519B2

公开(公告)日：2015-01-13

申请号：US10597525

申请日：2005-02-18

Applicant: Russell Keene ,  David R. Friswell ,  Mark Moeller ,  Charles Murphy ,  Theodore D. Ciolkosz

Inventor： Russell Keene ,  David R. Friswell ,  Mark Moeller ,  Charles Murphy ,  Theodore D. Ciolkosz

IPC: F16K11/14 ,  G01N30/20 ,  G01N30/22

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/207 ,  Y10T137/87249 ,  Y10T137/87692 ,  Y10T137/87708 ,  Y10T137/87788

Abstract: A pin valve assembly and a method of controlling the flow of fluids comprising a pin block housing pin valves, a fluid plate with a fluid channel for fluidically communicating with the pin valves, and a fitting block housing fittings for fluidic communication with the fluid plate and for fluidic communication with fluidic components. The fluid flow through the channels of the fluid plate are controlled by the fluidic components and the pin valves.

Abstract translation: 一种针阀组件和一种控制流体流动的方法，该流体组件包括销块容纳销阀，具有用于与销阀流体连通的流体通道的流体板，以及用于与流体板流体连通的配合块壳体配件，以及 用于与流体组分的流体连通。 通过流体板的通道的流体流动由流体组件和销阀控制。