公开(公告)号：US08539823B2

公开(公告)日：2013-09-24

申请号：US12546302

申请日：2009-08-24

Applicant: Beom-seok Lee

Inventor： Beom-seok Lee

IPC: G01N1/00 ,  F16K3/00 ,  B01L3/00 ,  F04B19/00 ,  F15C1/00 ,  G01N9/30 ,  G01N33/00 ,  F15C1/06

CPC classification number: G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00495 ,  Y10T137/206 ,  Y10T137/2224

Abstract: Provided is a microfluidic device. The microfluidic device includes a sample chamber in which a sample is accommodated. The sample chamber includes: an introduction portion including a loading hole through which the sample is loaded; an accommodation portion including a discharge hole; and a neck portion forming a boundary between the introduction portion and the accommodation portion. The neck portion provides a capillary pressure for controlling flow of the sample between the introduction portion and the accommodation portion.

Abstract translation: 提供了一种微流体装置。 微流体装置包括容纳样品的样品室。 样品室包括：引入部分，其包括加载样品的加载孔; 一个容纳部分，包括排放孔; 以及形成导入部和容纳部之间的边界的颈部。 颈部提供用于控制在引入部分和容纳部分之间的样品流动的毛细管压力。

公开(公告)号：US08469492B2

公开(公告)日：2013-06-25

申请号：US12620856

申请日：2009-11-18

Applicant: Beom-seok Lee ,  Jeong-gun Lee ,  In-seok Kang ,  Jin-seok Hong ,  Dustin Moon

Inventor： Beom-seok Lee ,  Jeong-gun Lee ,  In-seok Kang ,  Jin-seok Hong ,  Dustin Moon

IPC: B41J2/06

CPC classification number: B41J2/06 ,  B41J2/14

Abstract: A method of printing droplets using capillary electric charge concentration includes: providing a capillary nozzle comprising a back-end part and a front-end part disposed substantially opposite the back-end part; spacing a target member apart from the front-end part of the capillary nozzle at a predetermined distance; immersing the back-end part in a solution; and supplying a voltage to the solution. The back-end part transmits the solution to the front-end part.

Abstract translation: 使用毛细管电荷浓度印刷液滴的方法包括：提供包括后端部分和基本上与后端部分相对设置的前端部分的毛细管喷嘴; 将目标构件与毛细管喷嘴的前端部隔开预定距离; 将后端部分浸入溶液中; 并向该溶液提供电压。 后端部分将解决方案传输到前端部分。

公开(公告)号：US08420026B2

公开(公告)日：2013-04-16

申请号：US13594293

申请日：2012-08-24

Applicant: Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

Inventor： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

IPC: B04B13/00

CPC classification number: B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

Abstract: A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

Abstract translation: 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。

公开(公告)号：US08367398B2

公开(公告)日：2013-02-05

申请号：US12569437

申请日：2009-09-29

Applicant: Beom Seok Lee ,  Ji Won Kim ,  Jeong Gun Lee ,  Kui Hyun Kim

Inventor： Beom Seok Lee ,  Ji Won Kim ,  Jeong Gun Lee ,  Kui Hyun Kim

IPC: C12M1/36

CPC classification number: B01L3/50273 ,  B01L3/502738 ,  B01L3/545 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N21/07 ,  G01N33/54386 ,  G01N35/00069

Abstract: Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test.

Abstract translation: 提供了一种微流体装置，包括：微流体结构，用于提供用于接收流体的空间和用于形成流体流过的通道; 以及用于控制通过微流体装置中的通道的流体流动的阀。 微流体结构包括：样品室; 样品分离单元，从样品室接收样品，并通过离心力从样品中分离上清液; 接收来自样品分离单元的上清液的测试单元，用于使用抗原 - 抗体反应从上清液检测样品;以及质量控制室，用于识别测试的可靠性。

公开(公告)号：US20120028851A1

公开(公告)日：2012-02-02

申请号：US13269333

申请日：2011-10-07

Applicant: Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeong Park ,  Jeong-gun Lee

Inventor： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeong Park ,  Jeong-gun Lee

IPC: C40B60/12

CPC classification number: B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

Abstract: Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

Abstract translation: 提供了用于同时进行两种或更多种测定的可旋转的微流体装置。 该装置包括能够旋转的平台，第一单元，其设置在平台的一部分处，并且从附着有目标材料的捕获探针的样品使用表面检测目标材料;以及第二单元 其设置在平台的另一部分并且通过与在第一单元中进行的反应的不同反应来检测包含在样品中的目标材料。

公开(公告)号：US08101138B2

公开(公告)日：2012-01-24

申请号：US11837038

申请日：2007-08-10

Applicant: Jeong-gun Lee ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jong-myeon Park

Inventor： Jeong-gun Lee ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jong-myeon Park

IPC: B01L3/00 ,  F04B19/00

CPC classification number: G01N35/00069 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0803 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/043 ,  G01N35/0098 ,  Y10T436/25375

Abstract: A centrifugal micro fluidic system and a centrifugal magnetic position control device used in the centrifugal micro fluidic system for controlling the position of magnetic beads are provided. The centrifugal micro fluidic system comprising, a rotatable platform; a micro fluidic structure which is disposed in the platform; and a plurality of objects which include functional groups on surfaces thereof so as to capture a target material from the fluid and carry the target material while being suspended in and separated from the fluid in the micro fluidic structure, wherein the movements of the objects are controlled by a force affecting the objects differently compared to the force's effect on the fluid. When the objects are made of a magnetic material, the force may be a magnetic force applied by the centrifugal magnetic position control device.

Abstract translation: 提供了一种用于离心微流体系统中用于控制磁珠位置的离心微流体系统和离心磁位置控制装置。 离心微流体系统包括：可旋转平台; 设置在平台中的微流体结构; 以及包括在其表面上的官能团的多个物体，以便从流体中捕获目标材料并且在悬浮在微流体结构中的流体中并与微流体结构中的流体分离时携带目标材料，其中物体的移动被控制 通过影响对象的力与力对液体的影响不同。 当物体由磁性材料制成时，力可以是由离心磁位置控制装置施加的磁力。

公开(公告)号：US20110257037A1

公开(公告)日：2011-10-20

申请号：US13168298

申请日：2011-06-24

Applicant: Beom-seok LEE ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

Inventor： Beom-seok LEE ,  Jeong-gun Lee ,  Jong-myeon Park ,  Yoon-kyoung Cho

IPC: C40B40/00 ,  C40B40/10 ,  C40B40/02 ,  C40B40/06

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T436/15

Abstract: Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure.

Abstract translation: 公开了一种微流体装置，其包括在平台中形成的微流体结构，其中可以使用生物分子微阵列芯片自动执行各种检查，例如免疫血清检查。 使用生物分子微阵列芯片的生物分子微阵列芯片型微流器件包括：可旋转的平台; 设置在平台中的微流体结构，包括：多个室; 连接所述室的多个通道; 以及多个阀，其控制通过所述通道的流体流动，其中所述微流体结构通过所述平台和所述阀的旋转来控制流体样品的流动; 以及安装在平台中的生物分子微阵列芯片，使得与生物分子微阵列芯片结合的生物分子捕获探针与微流体结构中的流体样品接触。

公开(公告)号：US07980272B2

公开(公告)日：2011-07-19

申请号：US12133396

申请日：2008-06-05

Applicant: Jong-myeon Park ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

Inventor： Jong-myeon Park ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jeong-gun Lee

IPC: F15C1/04

CPC classification number: F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0084 ,  Y10T29/49412 ,  Y10T137/2191 ,  Y10T137/2196

Abstract: Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves.

Abstract translation: 本发明提供一种微流体阀，微流体阀的制造方法和采用该微流体阀的微流体装置。 该微流体阀包括一个平台，该平台包括彼此相结合的两个基板; 具有允许流体在两个基板之间流动的第一深度的通道; 阀间隙，其设置在所述通道的至少一个区域上，并且具有小于所述第一深度的第二深度; 以及阀塞，其设置成填充阀间隙，并且由阀室材料形成，所述阀门材料是通过将在室温下为固体的相变材料与多个放出足以熔化的 相变材料吸收电磁波。

公开(公告)号：US07979761B2

公开(公告)日：2011-07-12

申请号：US12331701

申请日：2008-12-10

Applicant: Bum-keun Kim ,  Kyung-young Kim ,  Jung-hwan Oh ,  Beom-seok Lee

Inventor： Bum-keun Kim ,  Kyung-young Kim ,  Jung-hwan Oh ,  Beom-seok Lee

IPC: G11C29/00

CPC classification number: G11C29/56 ,  G11C29/56004

Abstract: A memory test device, including a universal register to conduct an operation by a predetermined universal command language; an extension register having a larger capacity than the universal register and to conduct an operation by a predetermined extension command language; and a controller to write a predetermined test pattern in an external memory using the extension command language, to read the test pattern written in the memory, to determine the identity of the written test pattern and the read test pattern, and to determine a presence of an error in the memory using the universal command language.

Abstract translation: 一种存储器测试装置，包括通用寄存器，用于通过预定的通用命令语言进行操作; 扩展寄存器，其具有比通用寄存器更大的容量并且以预定的扩展命令语言进行操作; 以及使用扩展命令语言在外部存储器中写入预定测试模式的控制器，读取写入存储器中的测试模式，以确定写入的测试模式和读取的测试模式的身份，并且确定存在 使用通用命令语言的内存中的错误。

公开(公告)号：US20110015094A1

公开(公告)日：2011-01-20

申请号：US12888927

申请日：2010-09-23

Applicant: Beom-seok LEE ,  Jeong-gun LEE ,  Hye-jung CHO ,  In-seok KANG ,  Jae-suk MOON ,  Jin-seok HONG

Inventor： Beom-seok LEE ,  Jeong-gun LEE ,  Hye-jung CHO ,  In-seok KANG ,  Jae-suk MOON ,  Jin-seok HONG

IPC: C40B40/02 ,  C40B40/06 ,  C40B40/10 ,  C40B50/18

CPC classification number: B01L3/0262 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/027 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.

Abstract translation: 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储液器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。