公开(公告)号：US09295392B2

公开(公告)日：2016-03-29

申请号：US13625867

申请日：2012-09-24

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Alexandre Douplik ,  Desmond C. Adler ,  Brian C. Wilson ,  Norman Marcon

IPC: A61B6/00 ,  A61B5/00 ,  A61B1/04

CPC classification number: A61B5/0075 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4233

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract translation: 描述了一种使用在485,513,598和629nm的四个不同波长的最小四个波长进行漫反射测量的鉴别功能来计算发育不良与巴雷特食管（无论是否具有炎性成分）之间的统计学显着性差异的方法。 发现的鉴别功能取决于局部血液成分体积THB和氧合SO2。 公开了光谱数据采集的回退方法，其考虑了食管中的组织运动和测量几何特征。 拉回方法显着提高了测量重现性，并将数据偏差减少了75-100％，从而导致不同组织学组之间的更好区分。

公开(公告)号：US09143746B2

公开(公告)日：2015-09-22

申请号：US13930225

申请日：2013-06-28

Applicant: Novadaq Technologies Inc.

Inventor： Paul Westwick ,  David Potkins ,  John Fengler

IPC: H04N7/14 ,  H04N7/18 ,  A61B3/18 ,  A61B1/04 ,  A61B1/045 ,  A61B1/06 ,  H04N5/225 ,  H04N9/04 ,  A61B1/12

CPC classification number: H04N7/183 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  A61B3/18 ,  H04N5/2256 ,  H04N9/045 ,  H04N2005/2255

Abstract: An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.

Abstract translation: 公开了一种使用具有用于荧光和彩色成像的单色彩色图像传感器（例如CCD彩色图像传感器）的相机和用于以视频速率实时显示在这些成像模式中获取的图像的内窥镜视频系统和方法。 用荧光激发光连续照射被研究的组织，并使用荧光激发波长范围外的可见光进一步周期性地照射。 照明源可以是使用过滤器和百叶窗的常规灯，或者可以包括安装在内窥镜的远端的发光二极管。

公开(公告)号：US20150196208A1

公开(公告)日：2015-07-16

申请号：US14598832

申请日：2015-01-16

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Peter DVORSKY ,  David Mark Henri GOYETTE ,  T. Bruce FERGUSON, JR. ,  Cheng CHEN

IPC: A61B5/0275 ,  G06T7/40 ,  G06T7/00 ,  A61B5/00

CPC classification number: A61B5/0275 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7225 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B2576/02 ,  A61M5/007 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/248 ,  G06T7/90 ,  G06T2207/10064 ,  G06T2207/30104

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Abstract translation: 通过分析在心肌组织的荧光图像的集合中在静态感兴趣区域（ROI）中获得的荧光信号来确定血管灌注和心肌腮红。 腮红值是从图像元素的强度值的总强度确定的，该图像元素位于包含ROI内的所有图像元素的总测量图像强度的预定分数的图像强度值的最小连续范围内。 血管（动脉）峰强度由位于ROI内的图像元素确定，该图像元素具有最高测量图像强度值的最小相邻范围，并且包含ROI内所有图像元素的总测量图像强度的预定分数。 可以通过比较血管中峰值强度时间与手术前后相邻心肌组织区域的时间差来建立心脏功能。

公开(公告)号：US20130345560A1

公开(公告)日：2013-12-26

申请号：US13922996

申请日：2013-06-20

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： T. Bruce FERGUSON, JR. ,  Cheng CHEN

IPC: A61B5/00 ,  A61B5/026

CPC classification number: A61B5/0071 ,  A61B5/0261 ,  A61B5/0275 ,  A61B2505/05 ,  A61B2576/023 ,  A61K49/0034

Abstract: A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.

Abstract translation: 提供了一种用于可视化，显示，分析和量化血管造影，灌注以及实时血管造影和灌注变化的方法。 该方法从用于各种外科手术应用的红外荧光成像附近的吲哚菁绿捕获图像数据序列，其中血管造影和灌注对于术中决定至关重要。

公开(公告)号：US20130286176A1

公开(公告)日：2013-10-31

申请号：US13930225

申请日：2013-06-28

Applicant: Novadaq Technologies Inc.

Inventor： Paul WESTWICK ,  David POTKINS ,  John FENGLER

IPC: H04N7/18

CPC classification number: H04N7/183 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  A61B3/18 ,  H04N5/2256 ,  H04N9/045 ,  H04N2005/2255

Abstract: An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.

Abstract translation: 公开了一种使用具有用于荧光和彩色成像的单色彩色图像传感器（例如CCD彩色图像传感器）的相机和用于以视频速率实时显示在这些成像模式中获取的图像的内窥镜视频系统和方法。 用荧光激发光连续照射被研究的组织，并使用荧光激发波长范围外的可见光进一步周期性地照射。 照明源可以是使用过滤器和百叶窗的常规灯，或者可以包括安装在内窥镜的远端的发光二极管。

公开(公告)号：US20130217985A1

公开(公告)日：2013-08-22

申请号：US13850063

申请日：2013-03-25

Applicant: Novadaq Technologies Inc.

Inventor： Peter DVORSKY ,  David Mark Henri GOYETTE ,  T. Bruce FERGUSON, JR. ,  Cheng CHEN

IPC: A61B5/026 ,  A61B5/00 ,  A61M5/00

CPC classification number: A61B5/0275 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7225 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B2576/02 ,  A61M5/007 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/248 ,  G06T7/90 ,  G06T2207/10064 ,  G06T2207/30104

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.