公开(公告)号：US20190127780A1

公开(公告)日：2019-05-02

申请号：US16233880

申请日：2018-12-27

Applicant: STRECK, INC.

Inventor： Bradford A. Hunsley ,  Jianbing Qin

IPC: C12Q1/6806 ,  C12N15/10 ,  C12Q1/686

Abstract: A screening method for the identification of a characteristic of a target nucleic acid in a whole blood sample, including positioning a composition comprising whole blood and at least one preservative agent within a centrifuge, centrifugating the composition to isolate a plasma that includes at least one target nucleic acid for further analysis and analyzing the at least one target nucleic acid to identify a characteristic about the at least one target nucleic acid, and a composition including the plasma, the preservative agent, and any other ingredient, which is produced by the method.

公开(公告)号：US10144955B2

公开(公告)日：2018-12-04

申请号：US15894077

申请日：2018-02-12

Applicant: Streck, Inc.

Inventor： M. Rohan Fernando

IPC: C12P19/34 ,  C12Q1/6806 ,  C09K15/20

Abstract: Methods for preserving and processing cell-free nucleic acids are disclosed. The method includes a blood collection tube including a composition formulated for stabilizing cell-free nucleic acids within a blood sample. The composition includes least one formaldehyde releaser preservative agent; ethylenediaminetetraacetic acid (EDTA); and one or more solvents; and at least some formaldehyde and up to about 1% formaldehyde as a result of the at least one formaldehyde releaser preservative agent. The collected blood sample is storable for at least, or about 7 days without cell lysis and without cell-free nucleic acid degradation of the blood sample due to DNase and RNase activity after blood draw. The method may include isolating the cell free nucleic acids from the stabilized blood sample and testing the isolated cell free nucleic acids from the stabilized blood sample to identify the presence, absence or severity of a disease state.

公开(公告)号：US20180306719A1

公开(公告)日：2018-10-25

申请号：US16017507

申请日：2018-06-25

Applicant: STRECK, INC.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Gregg Wilder ,  John Flanagan ,  James Dowling ,  Philip Hills ,  Michael Tilleman ,  Jeremie Jackson

IPC: G01N21/64 ,  C12Q1/686 ,  B01L7/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2563/107 ,  G01N21/645 ,  G01N2201/062 ,  G01N2201/068

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

公开(公告)号：US20170052173A1

公开(公告)日：2017-02-23

申请号：US15239416

申请日：2016-08-17

Applicant: Streck, Inc.

Inventor： Brad Hunsley ,  Cathy Horstman ,  Kitty McCarthy

IPC: G01N33/50 ,  C12N5/076 ,  G01N1/30

CPC classification number: G01N33/5091 ,  A01N1/02 ,  A01N1/0231 ,  C12N5/061 ,  G01N1/30 ,  G01N33/502 ,  G01N2001/305 ,  G01N2496/25

Abstract: A reference control composition for use therein and methods for making the same, including a plurality of spermatozoa from a non-human source for simulating human spermatozoa and an effective amount of an agent for maintaining the plurality of spermatozoa in a substantially aggregate-free condition.

Abstract translation: 用于其中的参考对照组合物及其制备方法，包括来自用于模拟人类精子的非人源的多个精子和有效量的用于将多个精子维持在基本上无聚集状态的试剂。

公开(公告)号：US20160257995A1

公开(公告)日：2016-09-08

申请号：US15061557

申请日：2016-03-04

Applicant: Streck, Inc.

Inventor： Jianbing Qin ,  Bradford A. Hunsley

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q2527/101 ,  C12Q2527/125 ,  C12Q2527/137

Abstract: A composition and method for preserving a urine sample and a preservative delivery vessel are disclosed wherein treatment of the urine sample aids in preserving circulating cell-free nucleic acids in urine over a wide range of dilution ratios within temperature fluctuations that can occur during urine sample handling, storage and transportation. The urine sample preservation composition and method and preservative delivery vessel provide a method for obtaining high quality stabilized urinary cell-free nucleic acids for clinical diagnostics development and application.

Abstract translation: 公开了用于保存尿液样品和防腐剂输送容器的组合物和方法，其中尿液样品的处理有助于在尿液样品处理期间可能发生的温度波动范围内，在宽范围的稀释比范围内保护尿液中循环的无细胞核酸 ，仓储和运输。 尿样保存组合物和方法以及防腐输送容器提供了一种获得高质量稳定的无尿细胞核酸用于临床诊断开发和应用的方法。

公开(公告)号：US20140054508A1

公开(公告)日：2014-02-27

申请号：US14071969

申请日：2013-11-05

Applicant: Streck, Inc.

Inventor： M. Rohan Fernando

IPC: C09K15/20

CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

Abstract translation: 公开了一种用于保存和处理位于血液样品内的无细胞核酸的方法，其中处理含有无细胞核酸的血液样品以降低血液样品中的血细胞裂解和核酸酶活性。 样品的处理有助于增加可以鉴定和测试的无细胞核酸的量，同时保持核酸的结构和完整性。