公开(公告)号：US08888286B2

公开(公告)日：2014-11-18

申请号：US14137105

申请日：2013-12-20

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  A61B3/107 ,  G06T7/00

CPC classification number: A61B3/0025 ,  A61B3/0058 ,  A61B3/1005 ,  A61B3/101 ,  A61B3/107 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/10144 ,  G06T2207/20224 ,  G06T2207/30041

Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.

Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 TFLT可用于诊断干眼综合征（DES）。 某些实施例还包括眼部地形设备，用于通过捕获从角膜表面反射的目标的图像来推导角膜形状的系统和方法。 目标的图像包含地形信息，临床医生可以通过检测角膜畸形和/或角膜形状的异常来诊断患者眼睛的健康状况。 某些实施方案还包括OSI和眼部形貌设备的组合，用于提供可用于产生患者的泪膜和角膜形状的组合诊断的成像的系统和方法。

公开(公告)号：US11771317B2

公开(公告)日：2023-10-03

申请号：US17573899

申请日：2022-01-12

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  G06T7/00

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/30041

Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

公开(公告)号：US10952896B2

公开(公告)日：2021-03-23

申请号：US15359856

申请日：2016-11-23

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  John Martin Jans ,  Jordan W. Hutchinson ,  Keith Gausmann ,  Donald R. Korb

IPC: A61F9/007 ,  A61F7/00 ,  A61H7/00 ,  A61F7/12 ,  A61B17/22 ,  A61F7/02 ,  A61B17/00 ,  A61N7/00 ,  A61B18/04 ,  A61B18/12 ,  A61H15/00 ,  A61B18/08

Abstract: Apparatus and methods for treating dry eye include an energy source configured to apply energy to an obstruction located in a meibomian gland of a patient's eyelid. The apparatus also comprises an insulator configured to be positioned between a rear portion of the patient's eyelid and a surface of the patient's eyeball. An inner surface of the insulator has a curvature greater than that of the patient's eyeball such that an air pocket is formed between the inner surface of the insulator and the patient's eyeball, wherein the air pocket provides additional insulation to reduce or eliminate an amount of heat due to the applied energy from the energy source from being conducted to the surface of the patient's eyeball, such that the applied energy does not cause the temperature to reach a temperature sufficient to cause damage to a corneal or scleral portion of the patient's eyeball.

公开(公告)号：US10940074B2

公开(公告)日：2021-03-09

申请号：US16172159

申请日：2018-10-26

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Omer Jack Barrier ,  David Foshee ,  Donald R. Korb ,  Timothy R. Willis

IPC: A61H7/00 ,  A61F9/00 ,  A61F9/007 ,  A61B18/12 ,  A61B18/04 ,  A61F7/00 ,  A61H15/00 ,  A61N7/00

Abstract: An apparatus providing heat for treatment of an eyelid includes a heater unit configured to apply heat directly to an outer surface of the eyelid when an electrical signal is applied to the heater unit. The heater unit is affixed directly to the outer surface of the eyelid using an adhesive. A temperature regulator applies the electrical signal to the heater unit in order to achieve heating of the outer surface of the eyelid to a specified temperature range. A method is also disclosed that comprises affixing a heater unit directly into contact with the outer surface of the eyelid using an the adhesive. A control signal is applied to the heater unit to generate heat to the outer surface of the eyelid and is maintained for a period of time until the outer surface of the eyelid is heated to a specified temperature range.

公开(公告)号：US10716465B2

公开(公告)日：2020-07-21

申请号：US15892549

申请日：2018-02-09

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Steve Bacich

IPC: A61B3/00 ,  A61B3/10 ,  G06T7/00

Abstract: Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on tear film characteristics analysis and dry eye symptoms are disclosed. In embodiments herein, imaging of the ocular tear film is performed during contact lens wear. An analysis of the image of the ocular tear film is performed to determine one or more tear film characteristics of the ocular tear film. The tear film characteristics can be used to determine the effect or possible effect of contact lens wear on the ocular tear film, and thus be used to determine contact lens intolerance of the patient. The tear film characteristics used to analyze contact lens intolerance based on images of the ocular tear film involving contact lens wear may include dry eye symptoms, including but not limited to tear film (e.g., lipid and/or aqueous) thickness, tear film viscosity, and tear film movement rate in the eye.

公开(公告)号：US20200170502A1

公开(公告)日：2020-06-04

申请号：US16782384

申请日：2020-02-05

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

IPC: A61B3/10 ,  A61B3/00 ,  G06T7/00 ,  A61B3/14

Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

公开(公告)号：US10582848B2

公开(公告)日：2020-03-10

申请号：US16008619

申请日：2018-06-14

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/02 ,  A61B5/05 ,  A61B3/00 ,  G06T7/00

Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

公开(公告)号：US10299808B2

公开(公告)日：2019-05-28

申请号：US14510863

申请日：2014-10-09

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Timothy R. Willis ,  Stephen M. Grenon

IPC: A61F7/00 ,  A61F7/02 ,  A61H7/00 ,  A61N7/00 ,  A61B17/22 ,  A61B18/04 ,  A61B18/12 ,  A61F9/007 ,  A61H15/00

Abstract: Methods and apparatuses of treating meibomian glands are disclosed. The method comprises applying regulated heat to an eyelid to reach a temperature adequate to melt at least one obstruction within at least one meibomian gland. The method also comprises maintaining the regulated heat for a time period adequate to place the at least obstruction in the melted state. The method further comprises positioning a pressure application device into contact with the patient's eyelid and applying a pressure with the pressure application device over a substantial portion of the eyelid to express the at least one obstruction from the meibomian gland. An apparatus suitable to treat meibomian glands comprises a heater, a controller, and a pressure applicator configured to be placed into contact with the eyelid and apply a pressure over a substantial portion of the eyelid to express the at least one obstruction from the meibomian gland.

公开(公告)号：US20180296086A1

公开(公告)日：2018-10-18

申请号：US16008619

申请日：2018-06-14

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

IPC: A61B3/10 ,  A61B3/14 ,  G06T7/00 ,  A61B3/00

Abstract: Ocular surface interferometry devices, systems, and methods are disclosed for imaging an ocular tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image, wherein the specularly reflected light may be produced from various portions of the ocular tear film by obliquely illuminating various portions of the ocular tear film with a multi-wavelength light source, such as in a tiling pattern(s). The imaging device can also be focused on the lipid layer to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image, which can used to measure a tear film layer thickness.

公开(公告)号：US09999346B2

公开(公告)日：2018-06-19

申请号：US15589146

申请日：2017-05-08

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

IPC: A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  G06T7/00

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/30041

Abstract: Background reduction apparatuses and methods of Ocular Surface Interferometry (OSI) employing polarization are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT) and can be used to evaluate and potentially diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in at least one image. The at least one image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).