公开(公告)号：US09234873B2

公开(公告)日：2016-01-12

申请号：US14642982

申请日：2015-03-10

Applicant: AgaMatrix, Inc.

Inventor： Steven Diamond ,  Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei

IPC: G01N27/327 ,  G01N27/416

CPC classification number: G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

公开(公告)号：US20150133758A1

公开(公告)日：2015-05-14

申请号：US14601851

申请日：2015-01-21

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7225 ,  C12Q1/001 ,  C12Q1/006

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

Abstract translation: 校正聚合物层厚度的初始变化以及植入生物传感器之后发生的涂层厚度的变化，因此可以使用从电位衰减导出的因子提供可植入传感器的精度和使用寿命。

公开(公告)号：US09005424B2

公开(公告)日：2015-04-14

申请号：US14088967

申请日：2013-11-25

Applicant: AgaMatrix, Inc.

Inventor： Steven Diamond ,  Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei

IPC: G01N27/327 ,  G01N27/30 ,  C12Q1/00

CPC classification number: G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

Abstract translation: 提供了一种用于确定分析物浓度（例如葡萄糖浓度）的方法，其利用动态确定用于进行葡萄糖测量的适当时间，例如当电流对时间曲线基本上符合Cottrell衰变时，或当电流建立时 在高原地区。 动态确定进行测量的时间允许每个条带在最短的适当时间范围内运行，从而避免使用平均测量时间长于某些条带所需的时间，而对于其他条带来说太短。

公开(公告)号：US20150083610A1

公开(公告)日：2015-03-26

申请号：US14503529

申请日：2014-10-01

Applicant: AgaMatrix, Inc.

Inventor： Sridhar G. Iyengar ,  Ian Harding

IPC: G01N27/26

CPC classification number: G01N27/26 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/4168

Abstract: The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.

公开(公告)号：US08877033B2

公开(公告)日：2014-11-04

申请号：US13970117

申请日：2013-08-19

Applicant: AgaMatrix, Inc.

Inventor： Sridhar G. Iyengar ,  Ian Harding

IPC: G01N27/327 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/00 ,  A61B5/145 ,  G01N27/416

CPC classification number: G01N27/26 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/4168

Abstract: The presence of a select analyte in the sample is evaluated in an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.

Abstract translation: 在使用导电细胞型装置的电化学系统中评估样品中选择分析物的存在。 在电池的两个电极之间产生电势或电流，足以使分析物或分析物检测氧化还原系统中的介质发生氧化或还原，由此形成两个电极之间的分析物或介体的化学势梯度 梯度建立后，中止施加的电位或电流，并从化学势梯度的弛豫中获得与分析物无关的信号。 分析物独立信号用于校正在施加电位或电流期间获得的分析物依赖信号。 这种校正允许改进分析物浓度的测量，因为它校正了器件特异性和测试特定因素，例如分析物和/或介体的传输（迁移率），有效电极面积和电极间距（以及结果，样品体积）， 不需要单独的校准值。 可以使用手持式仪表中的一次性测试条进行分析，例如进行葡萄糖测试。

公开(公告)号：US08758594B2

公开(公告)日：2014-06-24

申请号：US13723713

申请日：2012-12-21

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

Abstract translation: 在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映 样品的氧气承载能力。 测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。

公开(公告)号：US20140083870A1

公开(公告)日：2014-03-27

申请号：US14088967

申请日：2013-11-25

Applicant: AgaMatrix, Inc.

Inventor： Steven Diamond ,  Ian Harding ,  Sridhar G. Iyentar ,  Baguo Wei

IPC: G01N27/30

CPC classification number: G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

Abstract translation: 提供了一种用于确定分析物浓度（例如葡萄糖浓度）的方法，其利用动态确定用于进行葡萄糖测量的适当时间，例如当电流对时间曲线基本上符合Cottrell衰变时，或当电流建立时 在高原地区。 动态确定进行测量的时间允许每个条带在最短的适当时间范围内运行，从而避免使用平均测量时间长于某些条带所需的时间，而对于其他条带来说太短。

公开(公告)号：US20130266489A1

公开(公告)日：2013-10-10

申请号：US13854222

申请日：2013-04-01

Applicant: AgaMatrix, Inc.

Inventor： Brad Boozer ,  Joseph Flaherty ,  Timothy Golnik ,  Ian Harding ,  Sridhar G. Iyengar

IPC: B01L3/00

CPC classification number: B01L3/508 ,  B65D43/021 ,  B65D43/0212 ,  B65D43/162 ,  B65D2543/00092 ,  B65D2543/00296 ,  B65D2543/00351 ,  B65D2543/00518 ,  B65D2543/00527 ,  B65D2543/00537 ,  B65D2543/00546 ,  B65D2543/00629 ,  B65D2543/00685 ,  B65D2543/0074 ,  B65D2543/00796 ,  B65D2543/00842 ,  B65D2543/00944 ,  G01N33/48778

Abstract: A diagnostic test strip vial has a container, a lid, and a plurality of diagnostic test strips. The container has a generally annular wall that terminates at a base and at an open mouth at an end that is opposite the base. The annular wall is cut at an oblique angle creating a wall that has a high side and a low side at the open mouth. The low side of the annular wall of the container is shorter in length than a diagnostic test strip that enclosed in the vial when the lid is closed with the container.

Abstract translation: 诊断测试条小瓶具有容器，盖子和多个诊断测试条。 容器具有大致环形的壁，其终止于底部并且在与底部相对的端部处的开口处。 环形壁以倾斜角度切割，产生在开口处具有高侧和低侧的壁。 容器的环形壁的低侧的长度比在用容器封闭盖子时封闭在小瓶中的诊断测试条的长度短。