公开(公告)号：US20150246897A1

公开(公告)日：2015-09-03

申请号：US14437177

申请日：2013-10-21

Applicant: Dietmar FLUBACHER ,  Nicole BIERI ,  Murat ACEMOGLU ,  Pascal MICHEL ,  Rasmus MOSE ,  Hans STETTLER ,  Caterina Maria TESTA ,  Jörg BROZIO ,  Frank SCHAEFER

Inventor： Flubacher Dietmar ,  Nicole Bieri ,  Murat Acemoglu ,  Pascal Michel ,  Rasmus Mose ,  Hans Stettler ,  Maria Caterina Testa ,  Joerg Brozio ,  Frank Schaefer

IPC: C07D401/04 ,  C07F5/02 ,  C07D213/75

CPC classification number: C07D401/04 ,  C07D213/75 ,  C07D239/28 ,  C07D239/42 ,  C07D401/14 ,  C07F5/025

Abstract: The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof.

Abstract translation: 本发明公开了制备化合物5-（2,6-二 - 4-吗啉基-4-嘧啶基）-4-三氟甲基吡啶-2-胺，其单盐酸盐及其中间体的改进方法。

公开(公告)号：US08715799B2

公开(公告)日：2014-05-06

申请号：US12668698

申请日：2008-07-15

Applicant: Frank Prissok ,  Frank Schaefer ,  Gitta Egbers ,  Ruediger Krech ,  Carsten Guenther

Inventor： Frank Prissok ,  Frank Schaefer ,  Gitta Egbers ,  Ruediger Krech ,  Carsten Guenther

IPC: B32B1/08 ,  C08K5/34 ,  C08K5/41

CPC classification number: C08G18/0895 ,  C08G18/4238 ,  C08K3/017 ,  C08K5/3445 ,  C08K5/41 ,  C08K2201/017 ,  Y10T428/1352 ,  Y10T428/139 ,  C08L75/04

Abstract: The present invention relates to antistatic, thermoplastic polyurethane comprising ethylmethylimidazole ethyl sulfate, to a process for production of antistatic, thermoplastic polyurethane comprising ethylmethylimidazole ethyl sulfate, and to the use of ethylmethylimidazole ethyl sulfate for the production of antistatic, thermoplastic polyurethane.

Abstract translation: 本发明涉及一种包含乙基甲基咪唑乙基硫酸酯的抗静电的热塑性聚氨酯，涉及用于制备包含乙基甲基咪唑乙基硫酸酯的抗静电的热塑性聚氨酯的方法，以及使用乙基甲基咪唑乙基硫酸酯制备抗静电的热塑性聚氨酯。

公开(公告)号：US20130169813A1

公开(公告)日：2013-07-04

申请号：US13809056

申请日：2011-07-11

Applicant: Frank Schaefer

Inventor： Frank Schaefer

IPC: B60C23/02

CPC classification number: B60C23/02 ,  B60C11/24 ,  B60C11/246 ,  G01B11/22 ,  G01L17/005 ,  G01M17/02 ,  G01M17/027

Abstract: A device for measuring tire parameters of a vehicle, comprising a detector for detecting a tire pressure of the vehicle, a measuring system for detecting a tire profile depth of the vehicle, and an output unit for outputting measured tire parameters that include and/or take into account the tire pressure and the tire profile depth. The detector and the measuring system have a measuring arrangement which is designed to be driven over by the vehicle and which is designed to measure the tire pressure as well as the tire profile depth in a moving vehicle, and the output unit is designed to display a result of the measurement such that an operating person that drives the vehicle can detect the measurement in the vehicle or from the vehicle directly after driving over the measuring arrangement.

Abstract translation: 一种用于测量车辆的轮胎参数的装置，包括用于检测车辆的轮胎压力的检测器，用于检测车辆的轮胎轮廓深度的测量系统，以及用于输出包括和/或采取的轮胎参数的测量系统 考虑轮胎压力和轮胎轮廓深度。 检测器和测量系统具有被设计成由车辆驱动并被设计成测量轮胎压力以及移动车辆中的轮胎轮廓深度的测量装置，并且输出单元被设计成显示 测量结果使得驾驶车辆的操作者可以在驾驶测量装置之后直接检测车辆或车辆中的测量。

公开(公告)号：US20120041119A1

公开(公告)日：2012-02-16

申请号：US13266199

申请日：2010-04-26

Applicant: Bin-Eric Chen ,  Frank Schaefer ,  Dirk Kempfert ,  Christoph Bahr ,  Guenter Scholz ,  Teruya Ohkuwa ,  Martin Vallo ,  Carsten Guenther ,  Harald Schulz ,  Yasuyuki Suzuki ,  Lim Tien Kuan

Inventor： Bin-Eric Chen ,  Frank Schaefer ,  Dirk Kempfert ,  Christoph Bahr ,  Guenter Scholz ,  Teruya Ohkuwa ,  Martin Vallo ,  Carsten Guenther ,  Harald Schulz ,  Yasuyuki Suzuki ,  Lim Tien Kuan

IPC: C08L75/06 ,  C08K5/11

CPC classification number: C08G18/664 ,  C08G18/0895 ,  C08G18/4238 ,  C08G18/4854 ,  C08G18/6674 ,  C08G18/7657 ,  C08G18/7671 ,  C08G18/797 ,  C08G2120/00 ,  C08J3/18 ,  C08J2375/04 ,  C08K5/0016 ,  C08K5/005 ,  C08K5/11 ,  C08L75/04

Abstract: The invention refers to a thermoplastic polyurethane produced from at least an organic diisocyanate and a compound which is reactive toward isocyanates, wherein the polyurethane comprises the ester of a tricarboxylic acid with at least one alcohol and wherein all acid groups of the tricarboxylic acid are esterified with an alcohol. The invention further refers to a process for producing the respective polyurethane, products comprising this thermoplastic polyurethane and the use of the ester of a tricarboxylic acid as plasticizer in thermoplastic polyurethanes.

Abstract translation: 本发明涉及由至少一种有机二异氰酸酯制得的热塑性聚氨酯和对异氰酸酯具有反应性的化合物，其中该聚氨酯包含三羧酸与至少一种醇的酯，其中三羧酸的所有酸基均被 一个酒精。 本发明还涉及生产各种聚氨酯的方法，包括该热塑性聚氨酯的产品以及三羧酸酯作为热塑性聚氨酯的增塑剂的用途。

公开(公告)号：US20110271705A1

公开(公告)日：2011-11-10

申请号：US13145814

申请日：2010-01-20

Applicant: Athanasios Athanasiou ,  Hans Ihle ,  Frank Schaefer

Inventor： Athanasios Athanasiou ,  Hans Ihle ,  Frank Schaefer

IPC: F25C1/00

CPC classification number: F25C1/04 ,  B67D2210/00005 ,  F25C2400/10 ,  F25C2400/14 ,  F25C2600/04 ,  F25D2323/121

Abstract: A household appliance, in particular a refrigeration device, in which ice bodies can be made of supplied water, includes a hose and/or tube assembly for supply of water to a receiving container, and a valve connected to the hose and/or tube assembly and constructed to release or suppress the water supply to the receiving container. The hose and/or tube assembly has zones in which a physical condition changes, wherein the valve is disposed in the hose and/or tube assembly in a region which has not yet encountered a change in the physical condition after water has been supplied into the hose and/or tube assembly.

Abstract translation: 一种家用电器，特别是制冷装置，其中冰体可以由供水供应，包括用于向接收容器供水的软管和/或管组件，以及连接到软管和/或管组件的阀 并构造成释放或抑制对接收容器的供水。 软管和/或管组件具有物理状态改变的区域，其中阀被设置在软管和/或管组件中，该区域在水已经被供应到 软管和/或管组件。

公开(公告)号：US20110269941A1

公开(公告)日：2011-11-03

申请号：US13121359

申请日：2009-09-28

Applicant: Johann Kubicek ,  Frank Schaefer ,  Joerg Labahn ,  Georg Bueldt

Inventor： Johann Kubicek ,  Frank Schaefer ,  Joerg Labahn ,  Georg Bueldt

IPC: C07K14/00 ,  B65B1/20 ,  B01D9/02

CPC classification number: C07K1/306 ,  B01D9/00 ,  B01D9/0077 ,  B01D2009/0086 ,  B01L3/06 ,  C07K14/705

Abstract: The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby, pre-filled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.

Abstract translation: 本发明涉及一种用于装载结晶装置和用于制造结晶装置的方法，所述结晶装置包括具有预定量的至少一种能够形成膜蛋白的结晶基质的基质形成化合物的多个容器，所述方法包括 以下步骤：a）将所述至少一种基质形成化合物的聚集状态改变为允许分配所述至少一种基质形成化合物的流体状态，以及b）分配限定量的所述至少一种基质形成 化合物进入结晶装置的至少一个容器中，其中所述分配的基质形成化合物在所述容器内固化。 由此，可以获得预填充的结晶装置，其可以用作特别是在自动结晶过程中的消耗品。 还提供了使用分别制备的结晶装置的蛋白质结晶方法。

公开(公告)号：US07494839B2

公开(公告)日：2009-02-24

申请号：US11011888

申请日：2004-12-13

Applicant: Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

Inventor： Hubert Benzel ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

IPC: H01L21/00

CPC classification number: B81C1/00158 ,  B81B3/007 ,  B81B2201/0264 ,  B81B2203/0127 ,  B81B2203/0315 ,  B81C2201/0115 ,  B81C2201/0116 ,  B81C2201/0136

Abstract: A manufacturing method for a micromechanical semiconductor element includes providing on a semiconductor substrate a patterned stabilizing element having at least one opening. The opening is arranged such that it allows access to a first region in the semiconductor substrate, the first region having a first doping. Furthermore, a selective removal of at least a portion of the semiconductor material having the first doping out of the first region of the semiconductor substrate is provided. In addition, a membrane is produced above the first region using a first epitaxy layer applied on the stabilizing element. In a further method step, at least a portion of the first region is used to produce a cavity underneath the stabilizing element. In this manner, the present invention provides for the production of the patterned stabilizing element by means of a second epitaxy layer, which is applied on the semiconductor substrate.

Abstract translation: 微机电半导体元件的制造方法包括在半导体衬底上提供具有至少一个开口的图案化稳定元件。 开口被布置成使得其允许接近半导体衬底中的第一区域，第一区域具有第一掺杂。 此外，提供了选择性地去除半导体衬底的第一区域中具有第一掺杂的半导体材料的至少一部分。 此外，使用施加在稳定元件上的第一外延层，在第一区域上方产生膜。 在另一方法步骤中，第一区域的至少一部分用于在稳定元件下方产生空腔。 以这种方式，本发明提供了通过施加在半导体衬底上的第二外延层来生产图案化的稳定元件。

公开(公告)号：US20080299190A1

公开(公告)日：2008-12-04

申请号：US11814274

申请日：2006-01-17

Applicant: Sabine Pfeffer ,  Frank Schaefer ,  Ricardo Schneeberger ,  Paul Allen Sutton ,  Martin Friedrich Trueby ,  Wolfgang Wirth

Inventor： Sabine Pfeffer ,  Frank Schaefer ,  Ricardo Schneeberger ,  Paul Allen Sutton ,  Martin Friedrich Trueby ,  Wolfgang Wirth

IPC: A61K9/20 ,  A61K9/14 ,  A61K31/4439 ,  A61K31/40 ,  A61K31/426 ,  A61K31/47 ,  C07D207/00 ,  A61K38/28 ,  A61K31/41 ,  A61P43/00

CPC classification number: A61K9/2018 ,  A61K9/2054 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4439 ,  Y10T428/2982

Abstract: This invention relates to tablets especially tablets formed by direct compression of a dipeptidylpeptidase IV (DPP-IV) inhibitor compound, a process for the preparation thereof; to new pharmaceutical formulations, and new tableting powders comprising DPP-IV inhibitor formulations capable of being directly compressed into tablets. The invention relates further to a process for preparing the tablets by blending the active ingredient and specific excipients into the new formulations and then directly compressing the formulations into the direct compression tablets. The invention also relates to vildagliptin particle size distribution and a new crystal form of vildagliptin particularly adapted for the preparation of improved tablets and other pharmaceutical compositions.

Abstract translation: 本发明涉及片剂，特别是通过直接压制二肽基肽酶IV（DPP-IV）抑制剂化合物形成的片剂，其制备方法; 新的药物制剂和包含能直接压制成片剂的DPP-IV抑制剂制剂的新的压片粉末。 本发明还涉及通过将活性成分和特定赋形剂混合到新制剂中然后将制剂直接压制成直接压制片剂来制备片剂的方法。 本发明还涉及维格列汀的粒度分布和新型晶体形式的维格列汀，特别适用于制备改进的片剂和其它药物组合物。

公开(公告)号：US07375238B2

公开(公告)日：2008-05-20

申请号：US10552835

申请日：2004-04-15

Applicant: Frank Schaefer ,  Gottfried Sedelmeier

Inventor： Frank Schaefer ,  Gottfried Sedelmeier

IPC: C07D207/16

CPC classification number: C07D207/16

Abstract: The present invention relates to a process for the preparation of a N-(N′-substituted glycyl)-2-cyanopyrrolidine comprising at least (a) reacting, in the presence of dimethylformamide, a compound of formula (V)  wherein, independently of each other, X1 and X3 are halogen; X2 is halogen, OH, O—C(═O)—CH2X3, —O—SO2—(C1-8)alkyl or 13 O—SO2-(aryl),  with L-prolinamide, followed by (b) reacting the resultant compound without isolation with a dehydration agent, optionally followed by (c) reacting, in the presence of a base, the resultant compound without isolation with an appropriate amine and (d) recovering the resultant compound in free form or in acid addition salt form.

Abstract translation: 本发明涉及一种制备N-（N'取代的甘氨酰基）-2-氰基吡咯烷的方法，该方法至少包含（a）在二甲基甲酰胺存在下使式（Ⅴ）化合物与 彼此之间，X 1和X 3是卤素; X 2是卤素，OH，OC（-O）-CH 2 X 3，-O-SO 2

公开(公告)号：US07354786B2

公开(公告)日：2008-04-08

申请号：US11223592

申请日：2005-09-08

Applicant: Hubert Benzel ,  Stefan Finkbeiner ,  Matthias Illing ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

Inventor： Hubert Benzel ,  Stefan Finkbeiner ,  Matthias Illing ,  Frank Schaefer ,  Simon Armbruster ,  Gerhard Lammel ,  Christoph Schelling ,  Joerg Brasas

IPC: H01L21/00

CPC classification number: G01L9/0045 ,  B81B2203/0315 ,  B81C1/00182 ,  G01P15/0802

Abstract: A micromechanical sensor element and a method for the production of a micromechanical sensor element that is suitable, for example in a micromechanical component, for detecting a physical quantity. Provision is made for the sensor element to include a substrate, an access hole and a buried cavity, at least one of the access holes and the cavity being produced in the substrate by a trench etching and/or, in particular, an isotropic etching process. The trench etching process includes different trenching (trench etching) steps which may be divided into a first phase and a second phase. Thus, in the first phase, at least one first trenching step is carried out in which, in a predeterminable first time period, material is etched out of the substrate and a depression is produced. In that trenching step, a typical concavity is produced in the wall of the depression. A passivation process is then carried out in that first phase, in which the concavity produced in the walls of the depression by the first trenching step is covered with a passivation material. The first trenching step and the first passivation process may be carried out repeatedly in alternating succession within the first phase, with the result that a typical corrugation is obtained on the walls of the depression so produced. In the second phase of the trench etching process, the cavity is produced through the at least one access hole produced by the depression, by carrying out a second trenching step of a predetermined second time period that is distinctly longer in comparison with the first time period.

Abstract translation: 微机械传感器元件和用于生产微机械传感器元件的方法，其适用于例如微机械部件中，用于检测物理量。 为传感器元件提供包括基板，进入孔和埋入空腔的设置，通过沟槽蚀刻和/或特别地，各向同性蚀刻工艺在基板中产生至少一个访问孔和空腔 。 沟槽蚀刻工艺包括可分为第一相和第二相的不同的开沟（沟槽蚀刻）步骤。 因此，在第一阶段中，执行至少一个第一开沟步骤，其中在可预定的第一时间段内将材料从衬底中蚀刻出来并产生凹陷。 在挖沟步骤中，在凹陷的壁上产生典型的凹陷。 然后在第一阶段进行钝化处理，其中通过第一开挖步骤在凹陷的壁中产生的凹陷被钝化材料覆盖。 第一开沟步骤和第一钝化工艺可以在第一阶段内连续交替重复进行，结果是在如此制造的凹陷的壁上获得典型的波纹。 在沟槽蚀刻工艺的第二阶段，通过执行与第一时间段相比明显更长的预定第二时间段的第二开沟步骤，通过由凹陷产生的至少一个访问孔产生空腔 。