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公开(公告)号：US09962705B2
公开(公告)日：2018-05-08
申请号：US14669419
申请日：2015-03-26
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , Byron J. Knight , David Opalsky
IPC: B01L3/00 , B01L9/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/12 , B03C1/14 , B25J11/00 , C12N15/10
CPC classification number: B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a portion of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.
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公开(公告)号：US20160060680A1
公开(公告)日：2016-03-03
申请号：US14213900
申请日：2014-03-14
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , David Opalsky , Jason F. RHUBOTTOM , Norbert D. HAGEN , Jennifer L. TIDD
IPC: C12Q1/68
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/527 , B01L3/565 , B01L7/5255 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , C12Q1/686 , G01N35/04 , G01N2035/0418 , G01N2035/0436
Abstract: A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.
Abstract translation: 诊断系统进行第一次核酸扩增反应和第二次不同的核酸扩增反应。 诊断系统包括隔室，其被配置为至少存储包含用于进行样品制备过程的第一体积试剂的第一体积试剂容器和包含用于进行第一反应的第二体积试剂的第二体试试剂容器。 所述系统包括被配置为存储至少一个包含用于进行第二反应的多个单位剂量试剂的单位剂量包装的室。 诊断系统被配置为使用提供给诊断系统的多个样本中的每一个上的第一批量试剂进行样品制备过程。 该系统被配置为在第一样品子集上使用第二本体试剂进行第一反应，并且在第二样品子集上使用多个第一单位剂量试剂进行第二反应。
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53.发明申请METHOD FOR IMPROVED THERMOCYCLING OF LOW VOLUME NUCLEIC ACID AMPLIFICATION REACTIONS 审中-公开改进低体积核酸放大反应的热循环的方法公开(公告)号：US20160032358A1
公开(公告)日：2016-02-04
申请号：US14212261
申请日：2014-03-14
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , David Opalsky , Jason F. RHUBOTTOM , Norbert D. HAGEN , Jennifer L. TIDD
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/527 , B01L3/565 , B01L7/5255 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , C12Q1/686 , G01N35/04 , G01N2035/0418 , G01N2035/0436
Abstract: A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. A receptacle distribution system is configured to receive a receptacle from the analyzer, transfer the receptacle into the processing module, and to move the receptacle between different locations within the analyzer. A substance transfer device of the module is configured to dispense substances into or remove substances from the receptacle within the processing module. A reagent card exchanger provides an input device for inserting reagent cards into and removing reagent cards from the module, stores reagent cards within the module, and transfers reagent cards to different location within the module.
Abstract translation: 处理模块被配置为扩展分析器的能力，所述分析器被配置为处理多个插座内的物质。 模块包括容器传送器，其被配置为将容器从处理模块内的位置传送到分析器内可由分析仪的物质转移装置访问的位置。 插座分配系统被配置为从分析器接收插座，将插座转移到处理模块中，并且使插座在分析器内的不同位置之间移动。 模块的物质转移装置被配置成在处理模块内将物质分配到或从容器中去除物质。 试剂卡交换机提供输入装置，用于将试剂卡插入模块中并从模块中移除试剂卡，将试剂卡存储在模块内，并将试剂卡转移到模块内的不同位置。
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公开(公告)号：US09171279B2
公开(公告)日：2015-10-27
申请号：US14195718
申请日：2014-03-03
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky
CPC classification number: G06Q10/087 , G01N35/00732 , G01N2035/00752 , G01N2035/00782 , G01N2035/00801 , G01N2035/00831 , G01N2035/00841
Abstract: A system and method for tracking items, such as receptacles, during a process employs a rack configured to hold one or more receptacles. Each receptacle includes a machine-readable label providing information regarding the receptacle, such as contents thereof and process(es) to be performed thereon, and each receptacle-receiving position of the rack has associated therewith a machine-readable label identifying the receptacle receiving location. The rack also includes a memory element to which electronic data may be written. A label reading device reads the machine-readable label on each receptacle and the position-indicating, machine-readable labels on the rack. Information obtained from the machine-readable labels is written to the memory element, so that for subsequent processing of the receptacles carried on the rack, information relating to each of the receptacles can be obtained by reading the information written to the memory element. A tamper prevention element provides an indication of whether the rack may have been tampered with after data is written to the memory element.
Abstract translation: 在过程期间用于跟踪物品（例如插座）的系统和方法采用配置成容纳一个或多个插座的机架。 每个插座包括提供关于插座的信息的机器可读标签，诸如其内容和要在其上执行的处理，并且机架的每个插座接收位置与其相关联地标识容器接收位置的机器可读标签 。 机架还包括可以写入电子数据的存储元件。 标签读取装置读取每个插座上的机器可读标签和机架上的位置指示机器可读标签。 从机器可读标签获得的信息被写入存储元件，因此为了随后处理在机架上承载的插座，可以通过读取写入存储元件的信息来获得与每个插座有关的信息。 防篡改元件提供了在将数据写入存储器元件之后机架是否可能被篡改的指示。
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公开(公告)号：US12229626B2
公开(公告)日：2025-02-18
申请号：US18476205
申请日：2023-09-27
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky , Rolf Silbert
Abstract: A method of reading machine-readable labels on sample receptacles. In the method, a sample rack is moved between a first position and a second position within a housing, where the sample rack supports a plurality of sample receptacles, and each sample receptacle has a machine-readable label. An absolute position of the sample rack is measured as the sample rack moves between the first and second positions. An image of the machine-readable label associated with each sample receptacle is acquired as the sample rack moves between the first and second positions. Finally, the acquired image of each machine-readable label is decoded.
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Patent Agency Ranking
公开(公告)号：US11840722B2
公开(公告)日：2023-12-12
申请号：US17146110
申请日：2021-01-11
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , David Opalsky , Jason F. Rhubottom , Norbert D. Hagen , Jennifer L. Tidd
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
Abstract: A diagnostic system is configured to perform first and second, different nucleic acid amplification reactions. The system includes a bulk reagent container compartment configured to store first bulk reagent container containing a first bulk reagent for performing sample preparation processes with a first subset and a second subset of a plurality of samples and a second bulk reagent container containing a second bulk reagent for performing the first nucleic acid amplification reaction. The system includes a unit-dose reagent compartment storing a unit-dose reagent pack including unit-dose reagents for performing the second nucleic acid amplification reaction. The system is configured to perform the sample preparation process using the first bulk reagent on the first and second subsets of the samples, perform the first nucleic acid amplification reaction using the second bulk reagent on the first subset of the samples, and perform the second nucleic acid amplification reaction using the unit-dose reagents on the second subset of the samples.
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公开(公告)号：US11834701B2
公开(公告)日：2023-12-05
申请号：US17878491
申请日：2022-08-01
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , Norbert D. Hagen , David Opalsky
IPC: B01L3/00 , B01L7/00 , G01N35/04 , C12Q1/6806 , C12Q1/686
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
Abstract: A reagent pack changer includes a reagent pack input device, a reagent pack storage compartment, a reagent pack storage carousel disposed within the storage compartment, and a rotary distributor. The input device includes a reagent pack input carousel rotatable about an axis of rotation, with reagent pack stations for holding reagent packs disposed around the axis of rotation of the carousel. The reagent pack storage carousel is rotatable about an axis of rotation with reagent pack stations for holding reagent packs disposed around the axis of rotation. The rotary distributor is configured to move a reagent pack between the reagent pack input carousel and the reagent pack storage carousel.
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公开(公告)号：US11788115B2
公开(公告)日：2023-10-17
申请号：US17033395
申请日：2020-09-25
Applicant: Gen-Probe Incorporated
Inventor： David Buse , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Tyler Moore , Byron J. Knight
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
Abstract: A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.
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公开(公告)号：US11704515B2
公开(公告)日：2023-07-18
申请号：US17399789
申请日：2021-08-11
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky
CPC classification number: G06K7/10811 , B01L3/545 , B01L3/5453 , B01L9/06 , G01N35/00732 , G06K7/10732 , G06K7/10861 , G06K7/10881 , G06K7/1447 , G06K19/06028 , B01L2300/021 , G01N2035/00752 , G01N2035/00801 , G01N2035/00831
Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.
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公开(公告)号：US11614454B2
公开(公告)日：2023-03-28
申请号：US17129522
申请日：2020-12-21
Applicant: Gen-Probe Incorporated
Inventor： Rolf Silbert , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to position the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.
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