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    Scattering spectroscopy nano sensor
    52.
    发明授权
    Scattering spectroscopy nano sensor 有权
    散射光谱纳米传感器

    公开(公告)号：US09389186B2

    公开(公告)日：2016-07-12

    申请号：US14968314

    申请日：2015-12-14

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven J Barcelo ,  Zhang-Lin Zhou

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

    Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

    Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

    Electric field generating apparatus for performing spectroscopy
    53.
    发明授权
    Electric field generating apparatus for performing spectroscopy 有权
    用于进行光谱的电场产生装置

    公开(公告)号：US09134249B2

    公开(公告)日：2015-09-15

    申请号：US13750695

    申请日：2013-01-25

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Brian C. Samuels ,  Zhiyong Li

    IPC: G01N21/00 ,  G01N21/55 ,  G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/4412 ,  G01J3/0205 ,  G01N21/658 ,  Y10T29/49155

    Abstract: According to an example, an apparatus for performing spectroscopy includes a substrate on which a plurality of surface-enhanced spectroscopy (SES) elements are positioned substantially along a first plane. The apparatus also includes a first electrode positioned adjacent to the plurality of SES elements substantially along the first plane and a second electrode positioned adjacent to the plurality of SES elements substantially along the first plane and on a side of the plurality of SES elements that is opposite the first electrode. The first electrode and the second electrode are to generate an electric field around the plurality of SES elements when voltages are applied through the first electrode and the second electrode.

    Abstract translation: 根据一个实例，用于执行光谱学的装置包括基本上沿着第一平面定位多个表面增强光谱（SES）元件的基板。 该装置还包括基本上沿着第一平面邻近多个SES元件定位的第一电极和基本沿着第一平面定位成与多个SES元件相邻的第二电极，并且在与多个SES元件相对的多个SES元件的一侧 第一个电极。 当通过第一电极和第二电极施加电压时，第一电极和第二电极将在多个SES元件周围产生电场。

    Apparatus for collecting material to be spectrally analyzed
    54.
    发明授权
    Apparatus for collecting material to be spectrally analyzed 有权
    用于收集要光谱分析的材料的装置

    公开(公告)号：US09097616B2

    公开(公告)日：2015-08-04

    申请号：US13750848

    申请日：2013-01-25

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Shih-Yuan Wang ,  Huei Pei Kuo ,  Zhiyong Li ,  Gary Gibson

    IPC: G01J3/44 ,  G01N1/00 ,  A61B5/00 ,  A61B5/1459 ,  G01N21/65 ,  G01N1/02

    CPC classification number: G01N1/00 ,  A61B5/0075 ,  A61B5/1459 ,  A61B5/6847 ,  A61B2562/028 ,  A61B2562/0285 ,  G01N1/02 ,  G01N21/658 ,  Y10T29/49826

    Abstract: According to an example, an apparatus for collecting a material to be spectrally analyzed includes a body having a first end and a second end, in which the body is elongated along a first axis from the first end to the second end. The body also includes a hole having an opening formed in an external surface of the body at a location between the first end and the second end and extending at least partially through the body at an angle with respect to the first axis. The body further includes a plurality of surface-enhanced spectroscopy (SES) elements positioned inside the body.

    Abstract translation: 根据一个示例，用于收集要被光谱分析的材料的装置包括具有第一端和第二端的主体，其中主体沿着第一轴从第一端延伸到第二端。 主体还包括孔，该孔具有在主体的外表面上形成在第一端和第二端之间的位置的开口，并且至少部分地穿过主体相对于第一轴线成一定角度延伸。 身体还包括位于体内的多个表面增强光谱（SES）元件。

    MOLECULAR SENSING DEVICE
    55.
    发明申请
    MOLECULAR SENSING DEVICE 审中-公开
    分子感测装置

    公开(公告)号：US20150002842A1

    公开(公告)日：2015-01-01

    申请号：US14372117

    申请日：2012-01-19

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Ansoon Kim ,  Zhiyong Li

    IPC: G01N1/28 ,  G01N21/65

    CPC classification number: G01N1/28 ,  G01N21/648 ,  G01N21/65 ,  G01N21/658 ,  G01N21/76 ,  G01N33/04 ,  Y10T29/49826

    Abstract: A molecular sensing device includes a substrate; a well i) formed in a material that is positioned on a surface of the substrate or ii) formed in a surface of the substrate; a signal amplifying structure positioned in the well; and a molecular selective device removably positioned in operative contact with the well.

    Abstract translation: 分子感测装置包括基板; 形成在位于基板的表面上的材料中，或ii）形成在基板的表面中的材料; 位于井中的信号放大结构; 以及可拆卸地定位成与井操作性接触的分子选择装置。

    METHOD FOR MONITORING AND CONTROLLING CELLULAR GROWTH
    56.
    发明申请
    METHOD FOR MONITORING AND CONTROLLING CELLULAR GROWTH 审中-公开
    监测和控制细胞生长的方法

    公开(公告)号：US20140370493A1

    公开(公告)日：2014-12-18

    申请号：US14475532

    申请日：2014-09-02

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Mineo Yamakawa ,  Zhiyong Li

    IPC: C12Q1/02

    CPC classification number: C12Q1/02 ,  C12M41/36 ,  C12M41/46 ,  C12Q3/00 ,  G01N33/4833

    Abstract: The present disclosure is drawn to a device for monitoring and controlling live cells and associated methods. In an example, the device can include a plurality of elongated nanostructures affixed to a substrate. The elongated nanostructures can each have an attachment end and a free end opposite the attachment end. The free end includes a metal and the attachment end is affixed to the substrate. The device can further include a functionalization layer that is coated on the free end of at least a portion of the plurality of elongated nanostructures. The functionalization layer can be formulated to retain live cells, and the device can be configured to be used in conjunction with a detector, such as a Raman spectrometer, in order to monitor growth of live cells.

    Abstract translation: 本公开涉及用于监测和控制活细胞和相关方法的装置。 在一个示例中，该装置可以包括固定到基底上的多个细长的纳米结构。 细长的纳米结构可以各自具有附接端和与附接端相对的自由端。 自由端包括金属，并且附接端固定到基底。 该装置还可以包括涂覆在多个细长纳米结构的至少一部分的自由端上的官能化层。 功能化层可以配制成保留活细胞，并且该装置可被配置为与诸如拉曼光谱仪的检测器结合使用，以便监测活细胞的生长。

    APPARATUS FOR FILTERING SPECIES
    57.
    发明申请
    APPARATUS FOR FILTERING SPECIES 有权
    过滤器物种

    公开(公告)号：US20140347661A1

    公开(公告)日：2014-11-27

    申请号：US14345277

    申请日：2011-10-27

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Ansoon Kim ,  Zhiyong Li ,  Wei Wu

    IPC: G01N21/05 ,  G01N21/65

    CPC classification number: G01N21/05 ,  B82Y20/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/491 ,  G01N2001/4088 ,  G01N2021/651

    Abstract: An apparatus for filtering species in a fluid includes a body having a first side and a second side, a first set of nano-fingers positioned on the body near the first side, a second set of nano-fingers positioned on the body closer to the second side than the first set of nano-fingers, wherein the nano-fingers in the second set of nano-fingers are arranged on the body at a relatively more densely than the nano-fingers in the first set of nano-fingers, and a cover positioned over the first set of nano-fingers and the second set of nano-fingers to form a channel with the body within which the first and second sets of nano-fingers are positioned.

    Abstract translation: 用于过滤流体中的物质的装置包括具有第一侧和第二侧的主体，位于第一侧附近的本体上的第一组纳米手指，位于身体上的第二组纳米手指， 第二组纳米手指的第二组，其中第二组纳米手指中的纳米手指以比第一组纳米手指中的纳米手指相对更密集地布置在身体上，并且 覆盖物定位在第一组纳米手指和第二组纳米手指之上，以与第一和第二组纳米手指定位的主体形成通道。

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