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    Biocompatible polymeric delivery systems for sustained release of quinazolinones
    53.
    发明申请
    Biocompatible polymeric delivery systems for sustained release of quinazolinones 审中-公开
    用于持续释放喹唑啉酮的生物相容性聚合物递送系统

    公开(公告)号：US20070184082A1

    公开(公告)日：2007-08-09

    申请号：US10590621

    申请日：2004-02-25

    Applicant: Shlomo Magdassi ,  Daniel Cohn

    Inventor： Shlomo Magdassi ,  Daniel Cohn

    IPC: A61F13/02 ,  A61K31/517

    CPC classification number: A61K31/517 ,  A61K9/0024 ,  A61K9/1652 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/7007

    Abstract: The present invention relates to biocompatible polymeric delivery systems for controlled or sustained release of quinazolinone derivatives, including the compound halofuginone. In particular the invention relates to a polymeric delivery system comprising biocompatible polymeric beads having a two-phase core and shell structure, or polymeric films, beads or complexes that provide local sustained release of the pharmacological agent.

    Abstract translation: 本发明涉及用于受控或持续释放喹唑啉酮衍生物（包括化合物卤伏酮酮）的生物相容性聚合物递送系统。 特别地，本发明涉及包含具有两相核心和壳结构的生物相容性聚合物珠粒或提供局部药物剂局部持续释放的聚合物膜，珠粒或复合物的聚合物递送系统。

    Sunscreen composition containing sol-gel microcapsules
    57.
    发明授权
    Sunscreen composition containing sol-gel microcapsules 失效

    公开(公告)号：US06468509B2

    公开(公告)日：2002-10-22

    申请号：US09840456

    申请日：2001-04-24

    Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

    Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

    IPC: A61K742

    CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/445 ,  A61K2800/412 ,  A61Q17/04 ,  Y10S514/962

    Abstract: The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

    Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
    58.
    发明授权
    Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof 失效
    总营养混合物作为稳定的多组分液体或干燥粉末及其制备方法

    公开(公告)号：US5997904A

    公开(公告)日：1999-12-07

    申请号：US723805

    申请日：1996-09-30

    Applicant: Shlomo Magdassi ,  Andrew Yang ,  Chunlin Tao ,  Neil P. Desai ,  Zhiwen Yao ,  Patrick Soon-Shiong

    Inventor： Shlomo Magdassi ,  Andrew Yang ,  Chunlin Tao ,  Neil P. Desai ,  Zhiwen Yao ,  Patrick Soon-Shiong

    IPC: A23L33/00 ,  A61K9/00 ,  A61K9/50 ,  A61K9/51 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61K9/14

    CPC classification number: A61K9/0029 ,  A23L33/40 ,  A61K9/0026 ,  A61K9/5052 ,  A61K9/5169 ,  B82Y5/00

    Abstract: In accordance with the present invention, there are provided stabilized total nutrient admixture (TNA) compositions which are useful for the in vivo parenteral delivery of pharmacologically acceptable lipids or fats, as well as methods for the preparation thereof. In particular, the pharmacologically acceptable lipid or fat is contained within a protein walled shell. In a particular embodiment of the invention, a TNA composition using human serum albumin (HSA) as a stabilizer has been prepared as a convenient three-in-one formulation (i.e., containing a fat emulsion, dextrose, and amino acids plus electrolytes). This "three-in-one" formulation can be prepared in liquid form or in dry form (comprising submicron-sized nanoparticles). The dried material is stable, even under long term storage, and is easily reconstituted immediately before use by simply adding sterile water (with or without vitamin supplementation). This serves to rehydrate the powder into a TNA suitable for injection. The long shelf life, ease of reconstitution, and single-component injectability of invention compositions provide significant cost savings, as such compositions can be reconstituted and administered safely, even in the home. In addition, HSA, the stabilizing agent of choice for use in the practice of the present invention, has been shown to improve survival and wellness when given as a supplement to patients receiving conventional forms of total nutrient admixtures.

    Abstract translation: 根据本发明，提供了可用于体内胃肠外递送药理学上可接受的脂质或脂肪的稳定的总营养混合物（TNA）组合物，以及其制备方法。 特别地，药理学上可接受的脂质或脂肪包含在蛋白质壁壳内。 在本发明的一个具体实施方案中，已经制备了使用人血清白蛋白（HSA）作为稳定剂的TNA组合物作为方便的三合一制剂（即含有脂肪乳剂，葡萄糖和氨基酸加电解质）。 这种“三合一”制剂可以以液体形式或干燥形式（包括亚微米尺寸的纳米颗粒）制备。 干燥的材料即使在长期储存下也是稳定的，并且在使用之前通过简单地加入无水（有或没有维生素补充剂）容易地重构。 这用于将粉末再水合成适合注射的TNA。 本发明组合物的长保存期限，易于重构和单组分可注射性提供显着的成本节约，因为即使在家中也可安全地重构和施用这些组合物。 此外，HSA是用于本发明实践的选择的稳定剂，已经显示出，当给予作为补充常规形式的总营养混合物的患者时，HSA可改善存活和健康。

    Method and pharmaceutical compositions for drug targeting
    59.
    发明授权
    Method and pharmaceutical compositions for drug targeting 失效
    用于药物靶向的方法和药物组合物

    公开(公告)号：US5858382A

    公开(公告)日：1999-01-12

    申请号：US592432

    申请日：1996-07-08

    Applicant: Shlomo Magdassi ,  Zichria Zakay Rones ,  Moshe Linevitz ,  Oren Shanberg

    Inventor： Shlomo Magdassi ,  Zichria Zakay Rones ,  Moshe Linevitz ,  Oren Shanberg

    IPC: A61K9/107 ,  A61K9/50 ,  A61K47/48 ,  A01N25/00

    CPC classification number: A61K9/107 ,  A61K47/488 ,  A61K9/5052 ,  Y10S514/938

    Abstract: A pharmaceutical composition comprising an oil/water emulsion wherein the oil droplets contain a drug in dissolved or dispersed or solubilized form. The droplets are further coated with adsorbed native or modified antibodies which provide targeting of the droplets and the drug. The process for preparing this composition comprises the steps of (i) dissolving or dispersing a drug in an oil phase, (ii) preparing an oil/water emulsion, (iii) obtaining surface-active antibodies by chemical or physical attachment of hydrophobic groups to the antibodies, and (iv) mixing the surface-active antibody with the emulsion.

    Abstract translation: PCT No.PCT / EP94 / 02577 371日期：1996年7月8日 102（e）日期1996年7月8日PCT 1994年8月3日PCT PCT。 公开号WO95 / 03829 日期1995年2月9日包含油/水乳液的药物组合物，其中油滴含有溶解或分散或溶解形式的药物。 液滴进一步涂覆有提供液滴和药物靶向的吸附的天然或修饰的抗体。 制备该组合物的方法包括以下步骤：（i）将药物溶解或分散在油相中，（ii）制备油/水乳液，（iii）通过将疏水基团化学或物理连接到 抗体，和（iv）将表面活性抗体与乳液混合。

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