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    Poly(ester amide) filler blends for modulation of coating properties
    53.
    发明申请
    Poly(ester amide) filler blends for modulation of coating properties 有权
    用于调节涂层性能的聚（酯酰胺）填料混合物

    公开(公告)号：US20060093842A1

    公开(公告)日：2006-05-04

    申请号：US10976551

    申请日：2004-10-29

    Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

    Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

    IPC: C08G63/02 ,  C08G69/08 ,  B32B27/34 ,  B32B27/36

    CPC classification number: C09D177/12 ,  A61L31/06 ,  A61L31/10 ,  Y10S623/90 ,  Y10T428/31725 ,  Y10T428/31786 ,  C08L77/12

    Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
    54.
    发明申请
    Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages 有权
    用于可植入装置的涂料包括聚（羟基链烷酸酯）和二酸键

    公开(公告)号：US20060034888A1

    公开(公告)日：2006-02-16

    申请号：US10902982

    申请日：2004-07-30

    Applicant: Stephen Pacetti ,  Thierry Glauser

    Inventor： Stephen Pacetti ,  Thierry Glauser

    IPC: A61K47/48 ,  C08G63/91

    CPC classification number: A61L31/10 ,  A61L27/34 ,  C08G63/66 ,  C09D167/00

    Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.

    Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的嵌段聚合物，至少一个生物相容性聚合物的嵌段和至少 一种类型的连接部分。

    Antifouling heparin coatings
    56.
    发明申请
    Antifouling heparin coatings 有权
    防污肝素涂层

    公开(公告)号：US20050266038A1

    公开(公告)日：2005-12-01

    申请号：US10857141

    申请日：2004-05-27

    Applicant: Thierry Glauser ,  Eugene Michal ,  Charles Claude ,  Stephen Pacetti

    Inventor： Thierry Glauser ,  Eugene Michal ,  Charles Claude ,  Stephen Pacetti

    IPC: A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  C08L1/00 ,  C08L33/10 ,  C08L33/14 ,  A61F2/06

    CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  C08L1/00 ,  C08L33/14 ,  C08L2666/26

    Abstract: A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    Abstract translation: 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

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