公开(公告)号：US07961304B2

公开(公告)日：2011-06-14

申请号：US12209807

申请日：2008-09-12

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: G01N33/48

CPC classification number: A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838

Abstract: Embodiments of the invention relate to a light illumination funnel. The funnel includes a first opening positioned to receive an incoming light source, a second opening positioned opposite the first opening and with a diameter smaller than the first opening and inner reflective walls, in contact with the first opening and second opening. The funnel has a half angle of less than 25 degrees. Embodiments also relate to a light collection funnel and an apparatus utilizing both a light illumination funnel and light collection funnel.

Abstract translation: 本发明的实施例涉及一种光照射漏斗。 漏斗包括定位成接收入射光源的第一开口，与第一开口相对定位并且具有小于第一开口和内反射壁的直径的第二开口，与第一开口和第二开口接触。 漏斗的半角小于25度。 实施例还涉及光收集漏斗和利用光照漏斗和光收集漏斗两者的装置。

公开(公告)号：US20090105565A1

公开(公告)日：2009-04-23

申请号：US12245298

申请日：2008-10-03

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/1455

CPC classification number: G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/474

Abstract: Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.

Abstract translation: 本发明的实施例涉及一种包括用于产生多个光束的光源的装置，其中多个光束中的每一个具有不同的波长范围。 该装置还包括一个光漏斗，用于将多个光束引导到目标区域，一个孔径，用于将从目标区域发射的多个光束引导到透镜，该透镜被配置成收集从目标区域发射的光束 。 此外，该装置包括检测器，其包括多个光感测装置，每个光感测装置被配置为检测光束并且被配置为产生指示所检测到的光的强度的输出信号，以及用于根据每个生成的功能确定血液特性的处理器 输出信号。

公开(公告)号：US20080102528A1

公开(公告)日：2008-05-01

申请号：US11923376

申请日：2007-10-24

Applicant: Zhi Xu ,  Chuanfen Xie ,  Chao Zeng

Inventor： Zhi Xu ,  Chuanfen Xie ,  Chao Zeng

IPC: G01N35/02

CPC classification number: G01N35/025 ,  G01N35/0092 ,  G01N2035/0094 ,  Y10T436/113332

Abstract: An automatic biochemical analyzing method is described, in which a row of reaction containers is cyclically arrayed such that an operating cycle is formed that is defined between dispensing the preceding sample and the sequent sample. In each cycle, the reaction containers are transferred so as to motivate at least one reaction container to pass across an optical detecting channel and cause the reaction containers to make an intermediate pause when no sample is dispensed. When the reaction containers pause, the sample is dispensed to a reaction container at a sample dispensing position. When the reaction containers are at the intermediate pause, the first reagent is dispensed to a reaction container at a first reagent dispensing position. In each reaction container, the operation cycle when the sample is dispensed follows the operation cycle when the first reagent is dispensed. An automatic biochemical analyzing apparatus is also disclosed.

Abstract translation: 描述了一种自动生化分析方法，其中一排反应容器循环排列，使得形成在分配前述样品和后续样品之间限定的操作循环。 在每个循环中，转移反应容器以便激励至少一个反应容器穿过光学检测通道，并且当没有样品被分配时使反应容器进行中间暂停。 当反应容器暂停时，样品在样品分配位置被分配到反应容器中。 当反应容器处于中间暂停时，第一试剂在第一试剂分配位置被分配到反应容器中。 在每个反应容器中，当分配样品时的操作循环在第一试剂被分配之后遵循操作循环。 还公开了一种自动生化分析装置。

公开(公告)号：US20070296971A1

公开(公告)日：2007-12-27

申请号：US11853682

申请日：2007-09-11

Applicant: David Larsen ,  Zhi Xu

Inventor： David Larsen ,  Zhi Xu

IPC: G01N21/00

CPC classification number: G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

Abstract: The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

Abstract translation: 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

公开(公告)号：US07262844B2

公开(公告)日：2007-08-28

申请号：US11035034

申请日：2005-01-13

Applicant: David W. Larsen ,  Zhi Xu

Inventor： David W. Larsen ,  Zhi Xu

IPC: G01J3/42

CPC classification number: G01N21/31 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J2003/425 ,  G01N21/274 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/0642 ,  G01N2201/127

Abstract: The invention concerns measurements in which light interacts with matter to generate light intensity changes, and spectrophotometer devices of the invention provide ultrasensitive measurements. Light source noise in these measurements can be reduced in accordance with the invention. Exemplary embodiments of the invention use sealed housings lacking an internal light source. In some embodiments a substantially solid thermally conductive housing is used. Other embodiments include particular reflection based sample and reference cells. One embodiment includes a prism including an interaction surface, a detector, a lens that focuses a prism beam output onto the detector, and a closed interaction volume for delivering gas or liquid to the interaction surface. Another embodiment replaces a prism with a reflective surface. Another embodiment replaces a prism with a scattering matte surface. Aspects of the invention identify noise-contributing components in spectrophotometry and realize noise levels very near the shot noise limit.

Abstract translation: 本发明涉及光与物质相互作用以产生光强度变化的测量，本发明的分光光度计装置提供超灵敏测量。 根据本发明，可以减少这些测量中的光源噪声。 本发明的示例性实施例使用缺少内部光源的密封外壳。 在一些实施例中，使用基本上固体的导热壳体。 其他实施方案包括特定的基于反射的样品和参比细胞。 一个实施例包括棱镜，其包括相互作用表面，检测器，将棱镜束输出聚焦到检测器上的透镜以及用于将气体或液体输送到相互作用表面的封闭相互作用体积。 另一个实施例用反射表面代替棱镜。 另一个实施例用散射磨砂表面代替棱镜。 本发明的方面在分光光度法中识别噪声贡献的组件，并且实现非常接近喷射噪声极限的噪声水平。

公开(公告)号：US20060152726A1

公开(公告)日：2006-07-13

申请号：US11035034

申请日：2005-01-13

Applicant: David Larsen ,  Zhi Xu

Inventor： David Larsen ,  Zhi Xu

IPC: G01J3/51

CPC classification number: G01N21/31 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J2003/425 ,  G01N21/274 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/0642 ,  G01N2201/127

Abstract: The invention concerns measurements in which light interacts with matter giving rise to changes in light intensity, and preferred embodiment spectrophotometer devices of the invention provide for ultrasensitive measurements through a reflection interaction with matter. The level of light source noise in these measurements can be reduced in accordance with the invention. Preferred embodiments of the invention use sealed housings lacking an internal light source, and reflection based sample and reference cells. In some embodiments a substantially solid thermally conductive housing is used. Other features of preferred embodiments include particular reflection based sample and reference cells. A total internal reflection embodiment includes, for example, a prism including an interaction surface, a detector, a lens that focuses a beam output from the prism onto the detector, and a closed interaction volume having an inlet and an outlet for delivering gas or liquid to the interaction surface. In a specular reflection embodiment, a reflective surface is used instead of a prism. In a diffuse reflection embodiment a matte surface is used instead of a prism and the matte surface produces scattering. Aspects of the invention include identification of noise-contributing components in spectrophotometry and the select set of preferred features in a given embodiment, and noise levels very near the shot noise limit may be realized with application of preferred embodiment devices.

Abstract translation: 本发明涉及测量光，其中光与引起光强变化的物质相互作用，并且本发明的优选实施方式的分光光度计装置通过与物质的反射相互作用来提供超灵敏测量。 根据本发明，可以减少这些测量中的光源噪声的水平。 本发明的优选实施例使用缺少内部光源的密封壳体，以及基于反射的样品和参考单元。 在一些实施例中，使用基本上固体的导热壳体。 优选实施方案的其它特征包括特定的基于反射的样品和参考细胞。 全内反射实施例包括例如包括相互作用表面的棱镜，检测器，将从棱镜输出的光束聚焦到检测器上的透镜以及具有用于输送气体或液体的入口和出口的封闭相互作用体积 到相互作用的表面。 在镜面反射实施例中，使用反射表面代替棱镜。 在漫反射实施例中，使用无光泽表面代替棱镜，并且无光泽表面产生散射。 本发明的方面包括在给定实施例中识别分光光度法中的噪声贡献成分以及在一特定实施例中选择的一组优选特征，并且通过应用优选实施例装置可以实现非常接近散粒噪声极限的噪声水平。