公开(公告)号：US20100130005A1

公开(公告)日：2010-05-27

申请号：US11461086

申请日：2006-07-31

Applicant: Byung Chul Lee ,  Jeong Oen Lee ,  Yang Kyu Choi ,  Jun-Bo Yoon

Inventor： Byung Chul Lee ,  Jeong Oen Lee ,  Yang Kyu Choi ,  Jun-Bo Yoon

IPC: H01L21/441 ,  B28B7/36 ,  B05D5/12

CPC classification number: H01L21/76877 ,  B81B2203/04 ,  B81B2207/07 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y10/00 ,  H01F41/041 ,  H01L21/76885 ,  H01L23/5223 ,  H01L23/5227 ,  H01L23/53276 ,  H01L51/0048 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A method of fabricating a semiconductor device by filling carbon nanotubes in a recess is disclosed. The method of fabricating the semiconductor device comprises patterning a mold on a substrate, coating carbon nanotubes on an entire surface of the recess and the mold formed by the patterning, filling the carbon nanotubes coated on the an entire surface of the mold in the recess, and removing the mold.

Abstract translation: 公开了一种通过在凹槽中填充碳纳米管来制造半导体器件的方法。 制造半导体器件的方法包括在基底上图案化模具，在凹部的整个表面上涂覆碳纳米管和通过图案化形成的模具，填充涂覆在凹部中的模具的整个表面上的碳纳米管， 并移除模具。

公开(公告)号：US20100055459A1

公开(公告)日：2010-03-04

申请号：US12439281

申请日：2007-08-30

Applicant: Joseph M. Desimone ,  Robert L. Henn ,  Jake Sprague

Inventor： Joseph M. Desimone ,  Robert L. Henn ,  Jake Sprague

IPC: B32B1/00 ,  B27N3/02

CPC classification number: H01B1/08 ,  B81C99/0095 ,  B81C2201/034 ,  B81C2201/038 ,  H01B1/02 ,  H01B13/00 ,  H01F1/01 ,  Y10T428/2982

Abstract: A plurality of nanoparticles, a structure assembled therefrom, a method of forming the structure, including a plurality of particles where each particle of the plurality of particles is configured with a substantially predetermined shape and a largest dimension less than about 100 micrometers, and where each particle of the plurality of particles includes an opening through the particle.

Abstract translation: 多个纳米颗粒，由其组装的结构，形成该结构的方法，包括多个颗粒，其中多个颗粒的每个颗粒被构造成具有基本上预定的形状和最小尺寸小于约100微米，并且其中每个 多个颗粒的颗粒包括穿过颗粒的开口。

公开(公告)号：US20090166903A1

公开(公告)日：2009-07-02

申请号：US12398132

申请日：2009-03-04

Applicant: Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Mara G. Prentiss ,  George M. Whitesides ,  Christian Marzolin

Inventor： Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Mara G. Prentiss ,  George M. Whitesides ,  Christian Marzolin

IPC: B29D11/00

CPC classification number: B81C1/00206 ,  A61K47/6957 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00416 ,  B01J2219/0043 ,  B01J2219/00466 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00713 ,  B29C31/04 ,  B29C33/42 ,  B29C37/0053 ,  B29C39/24 ,  B29C43/021 ,  B29C67/246 ,  B29D11/00346 ,  B29D11/00663 ,  B29K2105/0002 ,  B29L2011/0016 ,  B81B2201/0214 ,  B81C1/00031 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y30/00 ,  C40B60/14 ,  G01N21/7703 ,  G01N2021/7776 ,  G02B6/138 ,  H05K3/0079 ,  H05K3/061

Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.

Abstract translation: 化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。 化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。 衬底表面可以是平面的或非平面的。 聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。 制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。 涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。 可以制作波导阵列，组合化学或生化图谱等。 波导和包层的折射率差异可以通过将由凹凸预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生。 干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。 改变和折射率可以通过光化学，化学等方式产生。 还公开了传感器，包括生化传感器。

公开(公告)号：US07531120B2

公开(公告)日：2009-05-12

申请号：US10433275

申请日：2001-12-03

Applicant: Cornelis Johannes Maria Van Rijn ,  Laura Vogelaar ,  Wietze Nijdam ,  Jonathan Nathaniel Barsema ,  Matthias Wessling

Inventor： Cornelis Johannes Maria Van Rijn ,  Laura Vogelaar ,  Wietze Nijdam ,  Jonathan Nathaniel Barsema ,  Matthias Wessling

IPC: B29C39/00

CPC classification number: B01D67/0088 ,  A61F2/06 ,  A61F2002/044 ,  A61F2002/046 ,  A61L27/50 ,  A61L27/56 ,  B01D67/0009 ,  B01D67/0018 ,  B01D67/002 ,  B01D67/0069 ,  B01D67/0072 ,  B01D67/0093 ,  B01D69/00 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/02 ,  B01D71/64 ,  B01D71/68 ,  B01D2323/06 ,  B01D2323/08 ,  B01D2323/30 ,  B01D2325/022 ,  B01D2325/04 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00864 ,  B01J2219/00907 ,  B01L3/0241 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0819 ,  B29C33/0033 ,  B29C41/08 ,  B29C41/38 ,  B29C67/02 ,  B29K2105/0073 ,  B29L2031/737 ,  B81B2201/10 ,  B81C99/008 ,  B81C2201/0115 ,  B81C2201/034 ,  G01N27/44704 ,  H01L31/18 ,  Y10T428/24

Abstract: Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.

Abstract translation: 使用相分离技术穿孔以及非穿孔聚合物结构可以制成高纵横比（> 5）。 通过改变相分离方法，可以调节模制产品的性质（例如多孔，无孔，致密，开放的皮肤）。 应用在微流体学（例如微阵列，电泳板），光学，聚合太阳能电池，球栅阵列和组织工程领域中描述。

公开(公告)号：US20090085235A1

公开(公告)日：2009-04-02

申请号：US11277527

申请日：2006-03-27

Applicant: Erwin BURKLE ,  Steffen Burr ,  Martin Eichlseder ,  Bernd Klotz

Inventor： Erwin BURKLE ,  Steffen Burr ,  Martin Eichlseder ,  Bernd Klotz

IPC: B29C45/00

CPC classification number: B81C1/00206 ,  B29C37/0028 ,  B29C37/0053 ,  B29C37/0082 ,  B29C45/1679 ,  B29C45/372 ,  B29C2059/023 ,  B81C2201/034

Abstract: In a method and apparatus for making an article with a microstructure or nanostructure, an injection molding process or an injection-compression molding process is used to produce a substrate and to apply a microstructure or nanostructure upon a surface of the substrate. Subsequently, the substrate is inundated with a cross-linking, curing material.

Abstract translation: 在用于制造具有微结构或纳米结构的制品的方法和装置中，使用注射成型工艺或注射压缩模制方法来生产基底并将微结构或纳米结构施加到基底的表面上。 随后，用交联固化材料淹没基底。

公开(公告)号：US07494555B2

公开(公告)日：2009-02-24

申请号：US10945737

申请日：2004-09-20

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: B32B37/00

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US20080292888A1

公开(公告)日：2008-11-27

申请号：US11597281

申请日：2006-10-20

Applicant: Martyn John Hucker ,  Clyde Warsop

Inventor： Martyn John Hucker ,  Clyde Warsop

IPC: B32B17/06

CPC classification number: B81C1/00103 ,  B81B2201/038 ,  B81B2203/033 ,  B81B2203/0376 ,  B81B2203/0384 ,  B81C2201/034

Abstract: A method of forming a surface of micrometer dimensions conforming to a desired contour for a MEMS device, the method comprising providing a crystalline silicon substrate with a recess in an upper surface, providing a thinner layer of crystalline silicon over the upper surface of the substrate, fusion bonding the layer to the substrate under vacuum conditions, and applying heat to the layer and applying atmospheric pressure on the layer, such as to plastically deform the diaphragm within the recess to the desired contour. The substrate may form the fixed electrode of an electrostatic MEMS actuator, operating on the zip principle.

Abstract translation: 一种形成符合MEMS器件的期望轮廓的微米尺寸表面的方法，所述方法包括在上表面提供具有凹陷的晶体硅衬底，在衬底的上表面上提供更薄的晶体硅层， 在真空条件下将层熔合到衬底上，并且将热量施加到层上并在层上施加大气压力，例如使凹部内的隔膜塑性变形到期望的轮廓。 基板可以形成静电MEMS致动器的固定电极，以拉链原理运行。

公开(公告)号：US20080116608A1

公开(公告)日：2008-05-22

申请号：US12001564

申请日：2007-12-12

Applicant: Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca Jackman ,  Xiao-Mei Zhao ,  Stephen Smith ,  Mara Prentiss ,  George Whitesides ,  Christian Marzolin

Inventor： Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca Jackman ,  Xiao-Mei Zhao ,  Stephen Smith ,  Mara Prentiss ,  George Whitesides ,  Christian Marzolin

IPC: B29C45/16

CPC classification number: B81C1/00206 ,  A61K47/6957 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00416 ,  B01J2219/0043 ,  B01J2219/00466 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00713 ,  B29C31/04 ,  B29C33/42 ,  B29C37/0053 ,  B29C39/24 ,  B29C43/021 ,  B29C67/246 ,  B29D11/00346 ,  B29D11/00663 ,  B29K2105/0002 ,  B29L2011/0016 ,  B81B2201/0214 ,  B81C1/00031 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y30/00 ,  C40B60/14 ,  G01N21/7703 ,  G01N2021/7776 ,  G02B6/138 ,  H05K3/0079 ,  H05K3/061

Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.

Abstract translation: 化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。 化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。 衬底表面可以是平面的或非平面的。 聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。 制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。 涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。 可以制作波导阵列，组合化学或生化图谱等。 可以通过将由相同的预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生波导和包层的折射率差异。 干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。 改变和折射率可以通过光化学，化学等方式产生。 还公开了传感器，包括生化传感器。

公开(公告)号：US20080085551A1

公开(公告)日：2008-04-10

申请号：US11697140

申请日：2007-04-05

Applicant: Dong-Sung Kim ,  Tai-Hun Kwon

Inventor： Dong-Sung Kim ,  Tai-Hun Kwon

IPC: C12M1/34 ,  H01L21/77

CPC classification number: C12M3/00 ,  B01F5/0641 ,  B01F13/0059 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B81C1/00119 ,  B81C2201/034

Abstract: The present invention is directed to a microfluidic biochip based on an agglutination reaction that is frequently used in qualitative typing in the diagnostic medicine field by realizing a specimen inlet, a reagent inlet, a split microchannel, transfer microchannels, a chaos micromixer, a reaction microchamber, a microfilter, a passive microvalve, and an outlet on a plastic microchip. Particularly, the biochip of the present invention is characterized in that portability thereof is superior and a small amount (about 1 μl) of each of a specimen and a reagent is used. In addition, the biochip of the present invention can be cheaply made through conventional photolithography, electroplating, injection molding, and bonding. Therefore, by utilizing the microfluidic biochip for blood typing according to the present invention, a point-of-care diagnosis for performing blood typing based on an agglutination reaction at any place becomes possible.

Abstract translation: 本发明涉及一种基于凝集反应的微流体生物芯片，其通过实现样品入口，试剂入口，分离微通道，转移微通道，混沌微混合器，反应微室，经常用于诊断医学领域的定性分型 ，微型过滤器，被动微型阀和塑料微芯片上的出口。 特别地，本发明的生物芯片的特征在于其便携性优异，并且使用每个样本和试剂的少量（约1ul）。 此外，本发明的生物芯片可以通过常规的光刻，电镀，注射成型和粘合来廉价制造。 因此，通过利用根据本发明的用于血型分离的微流体生物芯片，可以在任何地方进行基于凝集反应进行血液分型的护理点诊断。

公开(公告)号：US07169314B2

公开(公告)日：2007-01-30

申请号：US10150895

申请日：2002-05-15

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: B81B5/00

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.