公开(公告)号：US08143322B2

公开(公告)日：2012-03-27

申请号：US12417826

申请日：2009-04-03

Applicant: Tai-Hun Kwon ,  Dong-Sung Kim ,  Kyoung-Je Cha

Inventor： Tai-Hun Kwon ,  Dong-Sung Kim ,  Kyoung-Je Cha

IPC: C08J9/26

CPC classification number: F04B19/006 ,  Y10T29/49236

Abstract: The present invention relates to a pump and pumping system for a microfluidic lab-on-a-chip, and a fabricating method thereof. An exemplary embodiment of the present invention provides a method of fabricating a pump for microfluidic lab-on-a-chips, the method including: infiltrating PDMS (polydimethylsiloxane) solution into a porous lump of water-soluble material; performing soft baking of the porous lump of water-soluble material containing the PDMS solution; and dissolving the porous lump of water-soluble material via water to obtain a porous PDMS structure.

Abstract translation: 本发明涉及一种用于微流体实验室的泵和泵送系统及其制造方法。 本发明的一个示例性实施例提供了一种制造用于微流体实验室的泵的方法，所述方法包括：将PDMS（聚二甲基硅氧烷）溶液浸入多孔的水溶性材料块中; 对含有PDMS溶液的水溶性物质的多孔块进行软烘烤; 并通过水溶解多孔的水溶性物质块，得到多孔PDMS结构。

公开(公告)号：US09217927B2

公开(公告)日：2015-12-22

申请号：US13128016

申请日：2009-11-02

Applicant: Bong-Kee Lee ,  Dong Sung Kim ,  Tai-Hun Kwon ,  Young Ok Lee

Inventor： Bong-Kee Lee ,  Dong Sung Kim ,  Tai-Hun Kwon

IPC: G03F7/20 ,  B81C99/00 ,  G03F7/00

CPC classification number: G03F7/2039 ,  B81C99/009 ,  G03F7/00

Abstract: Provided is a method for fabricating a microstructure. The method includes disposing an X-ray mask on photosensitive material and exposing the photosensitive material by radiating X-rays to the photosensitive material, etching the exposed photosensitive material, forming a mold having a micro-pattern by filing the etched photosensitive material with metal, forming a mold module by combining a plurality of molds, and forming a microstructure using the mold module.

Abstract translation: 提供了一种用于制造微结构的方法。 该方法包括在感光材料上设置X射线掩模，并通过向感光材料辐射X射线来曝光感光材料，蚀刻曝光的感光材料，通过用金属涂覆蚀刻的感光材料形成具有微观图案的模具， 通过组合多个模具来形成模具模块，并使用模具模块形成微结构。

公开(公告)号：US07718420B2

公开(公告)日：2010-05-18

申请号：US11697140

申请日：2007-04-05

Applicant: Dong-Sung Kim ,  Tai-Hun Kwon

Inventor： Dong-Sung Kim ,  Tai-Hun Kwon

IPC: C12M3/00

CPC classification number: C12M3/00 ,  B01F5/0641 ,  B01F13/0059 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B81C1/00119 ,  B81C2201/034

Abstract: The present invention is directed to a microfluidic biochip based on an agglutination reaction that is frequently used in qualitative typing in the diagnostic medicine field by realizing a specimen inlet, a reagent inlet, a split microchannel, transfer microchannels, a chaos micromixer, a reaction microchamber, a microfilter, a passive microvalve, and an outlet on a plastic microchip. Particularly, the biochip of the present invention is characterized in that portability thereof is superior and a small amount (about 1 μl) of each of a specimen and a reagent is used. In addition, the biochip of the present invention can be cheaply made through conventional photolithography, electroplating, injection molding, and bonding. Therefore, by utilizing the microfluidic biochip for blood typing according to the present invention, a point-of-care diagnosis for performing blood typing based on an agglutination reaction at any place becomes possible.

Abstract translation: 本发明涉及一种基于凝集反应的微流体生物芯片，其通过实现样品入口，试剂入口，分离微通道，转移微通道，混沌微混合器，反应微室，经常用于诊断医学领域的定性分型 ，微型过滤器，被动微型阀和塑料微芯片上的出口。 特别地，本发明的生物芯片的特征在于其便携性优异，并且使用每个样本和试剂的少量（约1μl）。 此外，本发明的生物芯片可以通过常规的光刻，电镀，注射成型和粘合来廉价制造。 因此，通过利用根据本发明的用于血型分离的微流体生物芯片，可以在任何地方进行基于凝集反应进行血液分型的护理点诊断。

公开(公告)号：US20070013106A1

公开(公告)日：2007-01-18

申请号：US11225150

申请日：2005-09-13

Applicant: Seung-Mo Lee ,  Tai-Hun Kwon

Inventor： Seung-Mo Lee ,  Tai-Hun Kwon

IPC: B28B7/36

CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  C03C17/326 ,  C03C2217/76

Abstract: Disclosed is a method of producing a hydrophobic polymer substrate including coating a curable photopolymer composition on a substrate, locating a micro- and nano-patterned hydrophobic template on the coated substrate, curing the curable photopolymer composition to prepare a curable photopolymer layer, and separating the curable photopolymer layer from the hydrophobic template.

Abstract translation: 公开了一种制备疏水聚合物基材的方法，包括在基材上涂覆可固化的光聚合物组合物，将微型和纳米图案化的疏水性模板定位在涂覆的基材上，固化可固化光聚合物组合物以制备可固化光聚合物层， 来自疏水性模板的可固化光敏聚合物层。

公开(公告)号：US20110254195A1

公开(公告)日：2011-10-20

申请号：US13128016

申请日：2009-11-02

Applicant: Bong-Kee Lee ,  Dong Sung Kim ,  Tai-Hun Kwon

Inventor： Bong-Kee Lee ,  Dong Sung Kim ,  Tai-Hun Kwon

IPC: B29C33/38

CPC classification number: G03F7/2039 ,  B81C99/009 ,  G03F7/00

Abstract: Provided is a method for fabricating a microstructure. The method includes disposing an X-ray mask on photosensitive material and exposing the photosensitive material by radiating X-rays to the photosensitive material using a side exposure scheme, etching the exposed photosensitive material, forming a mold having a micro-pattern by filing the etched photosensitive material with metal, forming a mold module by combining a plurality of molds, and forming a microstructure using the mold module.

Abstract translation: 提供了一种用于制造微结构的方法。 该方法包括在感光材料上设置X射线掩模，并通过使用侧曝光方案将感光材料照射到感光材料上曝光感光材料，蚀刻曝光的感光材料，通过将蚀刻过的 具有金属的感光材料，通过组合多个模具形成模具模块，并使用模具模块形成微结构。

公开(公告)号：US20100225685A1

公开(公告)日：2010-09-09

申请号：US12161771

申请日：2007-03-22

Applicant: Tai-Hun Kwon ,  Sung-Jae Park

Inventor： Tai-Hun Kwon ,  Sung-Jae Park

IPC: B41J29/38 ,  B01F5/02 ,  B01F13/00 ,  G05D11/02

CPC classification number: B01F15/0203 ,  B01F5/0085 ,  B01F5/0256 ,  B01F13/0071 ,  B01F13/1055 ,  B01F15/0255 ,  B67D7/74

Abstract: A droplet mixing apparatus can be applied for use with a variety of liquids, can provide a mixing speed of hundreds of nl/s by adjusting an opening/closing time of a solenoid valve, can effectively mix droplets, and can reduce a reaction time when applied to clinical appliances that utilize expensive liquids. The droplet mixing apparatus includes a plurality of pressure containers storing liquids that are to be dispensed, a plurality of solenoid valves that are respectively connected to the pressure containers to dispense the liquids fed from the pressure containers into a mixing container, and a control unit that controls the solenoid valves such that the solenoid valves are either simultaneously opened or alternately opened and closed.

Abstract translation: 液滴混合装置可以应用于各种液体，可以通过调节电磁阀的打开/关闭时间来提供数百nl / s的混合速度，可以有效地混合液滴，并可以减少反应时间 适用于使用昂贵液体的临床设备。 液滴混合装置包括存储要分配的液体的多个压力容器，分别连接到压力容器以将从压力容器供给的液体分配到混合容器中的多个电磁阀，以及控制单元， 控制电磁阀，使得电磁阀同时打开或交替打开和关闭。

公开(公告)号：US20080085551A1

公开(公告)日：2008-04-10

申请号：US11697140

申请日：2007-04-05

Applicant: Dong-Sung Kim ,  Tai-Hun Kwon

Inventor： Dong-Sung Kim ,  Tai-Hun Kwon

IPC: C12M1/34 ,  H01L21/77

CPC classification number: C12M3/00 ,  B01F5/0641 ,  B01F13/0059 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B81C1/00119 ,  B81C2201/034

Abstract: The present invention is directed to a microfluidic biochip based on an agglutination reaction that is frequently used in qualitative typing in the diagnostic medicine field by realizing a specimen inlet, a reagent inlet, a split microchannel, transfer microchannels, a chaos micromixer, a reaction microchamber, a microfilter, a passive microvalve, and an outlet on a plastic microchip. Particularly, the biochip of the present invention is characterized in that portability thereof is superior and a small amount (about 1 μl) of each of a specimen and a reagent is used. In addition, the biochip of the present invention can be cheaply made through conventional photolithography, electroplating, injection molding, and bonding. Therefore, by utilizing the microfluidic biochip for blood typing according to the present invention, a point-of-care diagnosis for performing blood typing based on an agglutination reaction at any place becomes possible.

Abstract translation: 本发明涉及一种基于凝集反应的微流体生物芯片，其通过实现样品入口，试剂入口，分离微通道，转移微通道，混沌微混合器，反应微室，经常用于诊断医学领域的定性分型 ，微型过滤器，被动微型阀和塑料微芯片上的出口。 特别地，本发明的生物芯片的特征在于其便携性优异，并且使用每个样本和试剂的少量（约1ul）。 此外，本发明的生物芯片可以通过常规的光刻，电镀，注射成型和粘合来廉价制造。 因此，通过利用根据本发明的用于血型分离的微流体生物芯片，可以在任何地方进行基于凝集反应进行血液分型的护理点诊断。

公开(公告)号：US20070012572A1

公开(公告)日：2007-01-18

申请号：US11335024

申请日：2006-01-19

Applicant: Seung-Mo Lee ,  Tai-Hun Kwon

Inventor： Seung-Mo Lee ,  Tai-Hun Kwon

IPC: C25D1/00

CPC classification number: C25D1/10

Abstract: Disclosed is a method of producing a mold for preparing a hydrophobic polymer substrate including forming an adhesion enhancer on a substrate, forming a first conductive layer on the adhesion enhancer, adhering a predetermined patterned hydrophobic template on the first conductive layer, forming a second conductive layer on the template to prepare a template assembly, metal electroplating on the template assembly to form a metal plating layer on the template assembly, and removing the first conductive layer, the second conductive layer, the adhesion enhancer, and the template from the template assembly.

Abstract translation: 公开了一种制备用于制备疏水性聚合物基材的模具的方法，包括在基材上形成粘合增强剂，在粘合增强剂上形成第一导电层，将预定的图案化疏水性模板粘附在第一导电层上，形成第二导电层 在模板上制备模板组件，在模板组件上进行金属电镀，以在模板组件上形成金属镀层，以及从模板组件移除第一导电层，第二导电层，粘附增强剂和模板。

公开(公告)号：US08313231B2

公开(公告)日：2012-11-20

申请号：US12161771

申请日：2007-03-22

Applicant: Tai-Hun Kwon ,  Sung-Jae Park

Inventor： Tai-Hun Kwon ,  Sung-Jae Park

IPC: B01F15/02

CPC classification number: B01F15/0203 ,  B01F5/0085 ,  B01F5/0256 ,  B01F13/0071 ,  B01F13/1055 ,  B01F15/0255 ,  B67D7/74

Abstract: A droplet mixing apparatus can be applied for use with a variety of liquids, can provide a mixing speed of hundreds of nl/s by adjusting an opening/closing time of a solenoid valve, can effectively mix droplets, and can reduce a reaction time when applied to clinical appliances that utilize expensive liquids. The droplet mixing apparatus includes a plurality of pressure containers storing liquids that are to be dispensed, a plurality of solenoid valves that are respectively connected to the pressure containers to dispense the liquids fed from the pressure containers into a mixing container, and a control unit that controls the solenoid valves such that the solenoid valves are either simultaneously opened or alternately opened and closed.

Abstract translation: 液滴混合装置可以应用于各种液体，可以通过调节电磁阀的打开/关闭时间来提供数百nl / s的混合速度，可以有效地混合液滴，并可以减少反应时间 适用于使用昂贵液体的临床设备。 液滴混合装置包括存储要分配的液体的多个压力容器，分别连接到压力容器以将从压力容器供给的液体分配到混合容器中的多个电磁阀，以及控制单元， 控制电磁阀，使得电磁阀同时打开或交替打开和关闭。

公开(公告)号：US20090252629A1

公开(公告)日：2009-10-08

申请号：US12417826

申请日：2009-04-03

Applicant: Tai-Hun KWON ,  Dong-Sung KIM ,  Kyoung-Je CHA

Inventor： Tai-Hun KWON ,  Dong-Sung KIM ,  Kyoung-Je CHA

IPC: F04B19/00 ,  B23P15/00

CPC classification number: F04B19/006 ,  Y10T29/49236

Abstract: The present invention relates to a pump and pumping system for a microfluidic lab-on-a-chip, and a fabricating method thereof. An exemplary embodiment of the present invention provides a method of fabricating a pump for microfluidic lab-on-a-chips, the method including: infiltrating PDMS (polydimethylsiloxane) solution into a porous lump of water-soluble material; performing soft baking of the porous lump of water-soluble material containing the PDMS solution; and dissolving the porous lump of water-soluble material via water to obtain a porous PDMS structure.

Abstract translation: 本发明涉及一种用于微流体实验室的泵和泵送系统及其制造方法。 本发明的一个示例性实施例提供了一种制造用于微流体实验室的泵的方法，所述方法包括：将PDMS（聚二甲基硅氧烷）溶液浸入多孔的水溶性材料块中; 对含有PDMS溶液的水溶性物质的多孔块进行软烘烤; 并通过水溶解多孔的水溶性物质块，得到多孔PDMS结构。