Abstract:
A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
Abstract:
Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
Abstract:
An optical sensor apparatus includes a light receiving element configured to produce an output according to a light receiving state, and an optical element including a reflecting layer including a metal film, and being arranged such that at least some of incident light on the light receiving element is light that is reflected by the reflecting layer. The optical element further includes a corrosion resistant layer for suppressing corrosion of the reflecting layer, and the reflecting layer includes a surface covered by the corrosion resistant layer formed by vapor plating.
Abstract:
Methods and apparatus are provided for detecting one or more contaminant particles in an environment with an optical sensor. The sensor includes at least one optical waveguide in a resonant arrangement and a light source positioned in an environment in which the presence of a contaminant particle is sought to be determined. The at least one optical waveguide is of a diameter that an evanescent tail of the lightwave extending there through extends into the environment and is reactive to at least one contaminant particle in the surrounding environment. A detector is positioned to receive light indicative of the sharpness of the optical resonance lineshape of the optical resonator at a pre-selected optical wavelength. The detected information determines the specific contaminant particle in the environment and the concentration of the contaminant particle in the environment.
Abstract:
Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.
Abstract:
Chemical and biosensors are disclosed. An optical waveguide is used to conduct electromagnetic radiation by total internal reflection in parallel through a reference waveguide portion and at least one analyte waveguide portion. The electromagnetic radiation is then converged into an exit beam. The external surface of at least the analyte portion is covalently modified, or functionalized, relative to the reference portion. Resulting interaction of the functionalized surface with molecules comprising an analyte causes a phase change in the electromagnetic radiation passing through the analyte portion relative to the reference portion sufficient to generate a corresponding and measurable interference pattern in the exit beam. A waveguide surface is functionalized by exposure to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The resulting reaction causes the functionalizing groups to covalently bond to the surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface. Thus, the waveguide surface can be made selectively responsive to a wide variety of analytes, including cells and other biological structures.
Abstract:
Disclosed is a microfluidic detection device including a circuit substrate and a transparent substrate. The circuit substrate is provided with at least one first light-emitting device used to emit a detection beam, a photodetector used to receive the detection beam and send out a sensing signal, and a control circuit electrically connected to the first light-emitting device and the photodetector. The transparent substrate overlaps the circuit substrate and is provided with a microfluidic channel and a light guide structure. The light guide structure has a light incident surface disposed corresponding to the first light-emitting device and a light exiting surface disposed corresponding to the photodetector. The light guide structure extends from each of the light incident surface and the light exiting surface to the microfluidic channel and is adapted to transmit the detection beam into and out of the microfluidic channel.
Abstract:
Methods and systems for detecting a gas or liquid in an environment include measuring a reference signal at each of a set of wavelengths by passing a signal at each wavelength through a reference cell having a gas or liquid to be detected. A sensing signal is measured at each of the plurality of wavelengths by coupling each wavelength to a ring resonator in the environment. A set of wavelengths that correspond to an absorption curve of the gas or liquid to be detected is determined. A concentration of the gas or liquid to be detected in the environment is determined based on amplitudes of the sensing signal at each of the set of wavelengths.
Abstract:
The present disclosure concerns a method and apparatus for measuring a sensor (10) comprising multiple optical resonators (11,12) optically connected to a single optical output interface (16). The optical resonators (11,12) are interrogated with a light input signal (Si). A light output signal (So) is measured from the optic al output interface (16) to determine a combined spectral response (Sa) covering a wavelength range (W) including a plurality of resonance peaks (λ1,i, λ2,j) for each of the optical resonators (11,12). A Fourier transform spectrum (FT) of the combined spectral response (Sa) is calculated and a harmonic series of periodic peaks (n·f1) is identified in the Fourier transform spectrum (FT). The harmonic series of periodic peaks is filtered to obtain a filtered Fourier transform spectrum (FT1) and a sensor signal is calculated (X1) based on the filtered Fourier transform spectrum (FT1).
Abstract:
Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.