中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

110 records (took 0.018 seconds)

    Kits for screening for blood coagulation disorders
    63.
    发明申请
    Kits for screening for blood coagulation disorders 有权
    用于筛查血液凝固障碍的试剂盒

    公开(公告)号：US20040235078A1

    公开(公告)日：2004-11-25

    申请号：US10856108

    申请日：2004-05-28

    Applicant: Instrumentation Laboratory Company

    Inventor： Bert Steffen Rosen ,  Christina Maria Yvonne Hall

    IPC: A61K038/37 ,  C12Q001/56

    CPC classification number: G01N33/86 ,  C12Q1/56 ,  Y10S435/975

    Abstract: In vitro methods for qualitative screening and/or quantitative determination of the functional activity of components of the Protein C anticoagulant pathway of blood coagulation are described. The methods entail measuring the conversion rate of a substrate by an enzyme, the activity of which is related to the Protein C anticoagulant activity, in a blood sample of a human comprising coagulation factors and said substrate, after at least partial activation of coagulation through the intrinsic, extrinsic or common pathway and triggering coagulation by adding calcium ions; and comparing said conversion rate with the conversion rate of a normal human blood sample determined in the same way. The methods include the addition of additional metal ions to the sample to enhance activity, sensitivity and resolution. Kits and reagents for use in the methods are also provided.

    Abstract translation: 描述了用于定性筛选和/或定量测定血液凝固蛋白C抗凝血途径的组分的功能活性的体外方法。 所述方法需要在包含凝血因子和所述底物的人的血液样品中测量底物的转化率，其活性与蛋白C抗凝血活性有关，在通过 内在的，外在的或共同的途径，并通过加入钙离子引发凝血; 并将所述转化率与以相同方式测定的正常人血液样品的转化率进行比较。 这些方法包括向样品中加入额外的金属离子以增强活性，灵敏度和分辨率。 还提供了用于方法的试剂盒和试剂。

    DETECTING AND MONITORING ORAL ANTICOAGULANTS OR INTRAVENOUS DIRECT THROMBIN INHIBITORS IN A BLOOD SAMPLE
    66.
    发明申请
    DETECTING AND MONITORING ORAL ANTICOAGULANTS OR INTRAVENOUS DIRECT THROMBIN INHIBITORS IN A BLOOD SAMPLE 有权

    公开(公告)号：US20240379198A1

    公开(公告)日：2024-11-14

    申请号：US18782377

    申请日：2024-07-24

    Applicant: Instrumentation Laboratory Company

    Inventor： Simon Schäfer ,  Philipp Groene ,  Klaus Görlinger

    IPC: G16H10/40 ,  G01N11/00 ,  G01N33/49

    Abstract: An example method detecting a presence of one or more oral anticoagulants or intravenous (IV) direct thrombin inhibitors in a blood sample may include the following operations: receiving parameters that are based on viscoelastic tests; comparing the parameters to predefined threshold values, where the parameters and the predefined threshold values are based on an identity of the one or more oral anticoagulants or the IV direct thrombin inhibitors; and detecting, based on the comparing, the presence of the one or more oral anticoagulants or IV direct thrombin inhibitors in the blood sample. The viscoelastic tests are performed on portions of the blood sample to obtain the parameters. The viscoelastic tests include both a viscoelastic test based on Ecarin activation and a viscoelastic test with low tissue factor activation.

    Ultrasound lysing of whole blood
    70.
    发明授权
    Ultrasound lysing of whole blood 有权

    公开(公告)号：US11745177B2

    公开(公告)日：2023-09-05

    申请号：US16738915

    申请日：2020-01-09

    Applicant: Instrumentation Laboratory Company

    Inventor： Brian Joseph Bosy ,  Josef Kerimo

    IPC: B01L3/00 ,  G01N1/28 ,  G01N21/31 ,  G01N33/72

    CPC classification number: B01L3/502 ,  G01N1/28 ,  G01N21/31 ,  G01N33/721 ,  B01L2200/04 ,  B01L2300/06 ,  B01L2300/08 ,  B01L2300/12

    Abstract: A system and method for lysing of whole blood for CO-Ox measurement uses a lysing chamber for acoustic lysing of whole blood in a module in which the lysing chamber is separate from a CO-Ox measurement chamber. The disclosed acoustic lysing system and method avoids the expense and complexity of chemical lysing methods and allows the whole blood sample to be lysed while under continuous flow through the lysing chamber. The acoustic lysing chamber is provided upstream from a CO-Ox measurement chamber. The separation of the lysing chamber from the Co-Ox measurement chamber provides freedom to arrange and orient various optical components and/or other CO-Ox measuring components around the CO-Ox measurement chamber. The decoupling of the lysing chamber from the CO-Ox measurement chamber allows for more efficient design of the ultrasonic lysing transducer and CO-Ox measurement optics.

Patent Agency Ranking