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公开(公告)号：US20200316289A1
公开(公告)日：2020-10-08
申请号：US16783003
申请日：2020-02-05
Applicant: University of Iowa Research Foundation
Inventor： Enrique C. Leira , Thomas Schnell , Salam F. Rahmatalla , Andrew A. Pieper , Anil Chauhan
Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.
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62.发明申请公开(公告)号：US20200289611A1
公开(公告)日：2020-09-17
申请号：US16301426
申请日：2017-05-12
Applicant: Cedric Pearce , University of North Carolina at Greensboro , University of Iowa Research Foundation , The United State Government as Represented by the Department of Veterans
Inventor： Nicholas Oberlies , Cedric Pearce , Alexander Horswill , Jeffrey Kavanaugh , Corey Parlet , Tamam El-Elimat
Abstract: This disclosure is directed to novel apicidin methods and compositions for the inhibition of quorum sensing in bacterial infections and novel apicidin methods and compositions for treating a staphylococcal infection.
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63.发明申请公开(公告)号：US20200264323A1
公开(公告)日：2020-08-20
申请号：US16061533
申请日：2016-12-20
Applicant: University of Iowa Research Foundation
Inventor： Ugur Akgun , Yasar Onel
Abstract: A scintillating material that is a radiation hardened plastic and flexible elastomer is disclosed. The material is useful in a wide range of high energy particle environments and can be used to create detectors. Such detectors can be used in physics experiments or in medical treatment or imaging. The scintillator can be radiation hardened so as to allow for an extended lifetime over other materials.
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公开(公告)号：US20200255883A1
公开(公告)日：2020-08-13
申请号：US16651863
申请日：2018-09-27
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： James O. McNamara
IPC: C12Q1/44 , C12Q1/6816
Abstract: In certain embodiments, the present invention provides a detection composition comprising a picodroplet comprising (a) an aqueous solution, and (b) a substrate probe comprising (i) an oligonucleotide of 2 to 75 nucleotides in length, (ii) a fluorophore operably linked to the oligonucleotide, and (iii) a quencher operably linked to the oligonucleotide. As used herein, the term “picodroplet” comprises a liquid droplet that has a volume of 0.014 to 2.6 picoliters. In certain embodiments, the present invention provides a method of detecting at least one individual nuclease molecule present in a sample, comprising contacting an aqueous sample suspected of containing at least one nuclease with at least one detection composition comprising a picodroplet comprising (a) an aqueous solution, and (b) a substrate probe comprising (i) an oligonucleotide of 2 to 75 nucleotides in length, (ii) a fluorophore operably linked to the oligonucleotide, and (iii) a quencher operably linked to the oligonucleotide to form an aqueous reaction mixture; emulsifying the aqueous mixture in oil to form picoliter-scale droplets in an emulsion, (c) incubating the picoliter-scale droplets in the emulsion in order for the nuclease, if present, to digest the substrate probes linked to the microbeads; recovering the microbeads; and detecting fluorescence emitting from the microbeads.
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公开(公告)号：US10729669B2
公开(公告)日：2020-08-04
申请号：US15748506
申请日：2016-07-26
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Andrean L. Simons-Burnett
IPC: A61K31/192 , A61K31/437 , A61K31/4706 , A61K31/662 , A61P35/00 , A61K31/66 , A61K39/395 , C07K16/28
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof and an anti-cancer composition.
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Patent Agency Ranking
公开(公告)号：US20200170813A1
公开(公告)日：2020-06-04
申请号：US16787291
申请日：2020-02-11
Applicant: The University of Iowa Research Foundation
Inventor： Benjamin Dickerhoff , Robert S. Farivar , Madhavan L. Raghavan , Vijay Kumar
IPC: A61F2/86 , C22F1/10 , C21D1/18 , B29C39/10 , B29C39/02 , A61F2/95 , A61L27/50 , A61L27/20 , A61F2/24
Abstract: Vascular prosthetic assemblies (e.g., heart valves), such as those, for example, configured to be deployed percutaneously.
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公开(公告)号：US10669543B2
公开(公告)日：2020-06-02
申请号：US15543816
申请日：2016-01-15
Applicant: University of Iowa Research Foundation
Inventor： Liu Hong , Brad A. Amendt , Aliasger K. Salem , Satheesh Elangovan , Gustavo Avila Ortiz , Thad Sharp
Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
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公开(公告)号：US20200009267A1
公开(公告)日：2020-01-09
申请号：US16457332
申请日：2019-06-28
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Beverly L. Davidson , Luis Tecedor , Young Hong Chen
IPC: A61K48/00 , A61K31/343
Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
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公开(公告)号：US10426528B2
公开(公告)日：2019-10-01
申请号：US15141745
申请日：2016-04-28
Applicant: The University of Iowa Research Foundation
Inventor： Stephanus V. Viljoen , Andrew Grossbach
IPC: A61B17/70
Abstract: A system and method for stabilizing a spine of an animal subject involving a transverse rod installation instrument assembly for inserting a transverse rod on the spine of a subject percutaneously comprising: a first rod clamp extender mounted on a ipsilateral rod clamp and a second rod clamp extender mounted on a contralateral rod clamp wherein the ipsilateral rod clamp and the contralateral rod clamp are secured to a vertebra at the ipsilateral and contralateral pedicle; and a pivoting installation instrument pivotably mounted to the first rod clamp extender and the second rod clamp extender to pass a transverse rod percutaneously through a head portion of the ipsilateral side rod clamp and to the head portion of the contralateral rod clamp after passing through a spinous process of the vertebra through pivot axis “A” such that the transverse rod is secured at the head portion of the ipsilateral rod clamp and the head portion of the contralateral rod clamp.
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70.发明申请公开(公告)号：US20190270807A1
公开(公告)日：2019-09-05
申请号：US16217567
申请日：2018-12-12
Inventor： Adisa KUBURAS , Bianca MASON , Levi P. SOWERS , Andrew F. RUSSO , Maria-Cristina LOOMIS , Leon F. GARCIA-MARTINEZ , Benjamin H. DUTZAR , Daniel S. ALLISON , Katherine Lee HENDRICKS , Ethan W. OJALA , Pei FAN , Jeffrey T.L. SMITH , John A. LATHAM , Charlie KARASEK , Jenny MULLIGAN , Michelle SCALLEY-KIM , Erica STEWART , Vanessa Lisbeth RUBIN , Jens J. BILLGREN
Abstract: This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof
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