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    Inductive Damping Brain Sensor
    61.
    发明申请
    Inductive Damping Brain Sensor 有权

    公开(公告)号：US20210251546A1

    公开(公告)日：2021-08-19

    申请号：US17179018

    申请日：2021-02-18

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Shane S. Shahrestani

    IPC: A61B5/245 ,  A61B5/00 ,  A61B5/06

    Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

    Neuromodulation systems and methods of using same
    62.
    发明授权
    Neuromodulation systems and methods of using same 有权

    公开(公告)号：US10786673B2

    公开(公告)日：2020-09-29

    申请号：US15713456

    申请日：2017-09-22

    Applicant: California Institute of Technology

    Inventor： Mandheerej Nandra ,  Yu-Chong Tai

    IPC: A61N1/36 ,  A61B5/0488 ,  A61B5/00 ,  A61N1/05 ,  A61N1/378

    Abstract: Neuromodulation systems are described. An example neuromodulation system includes a controller wirelessly communicatively coupled to a host computer, a signal generator communicatively coupled to the controller, and a plurality of electrodes communicatively coupled to the signal generator. The controller, in conjunction with the signal generator and the at least one electrode are configured to deliver a stimulation to a mammal based on an instruction received from the host computer. The stimulation is configured to induce voluntary movement or restore function in the mammal.

    Tear Flow Measurement Device
    63.
    发明申请
    Tear Flow Measurement Device 审中-公开

    公开(公告)号：US20200260946A1

    公开(公告)日：2020-08-20

    申请号：US16786377

    申请日：2020-02-10

    Applicant: California Institute of Technology ,  University of Southern California

    Inventor： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Mark S. Humayun

    IPC: A61B3/10 ,  G01N30/02 ,  G01G19/00 ,  G01F22/00 ,  G01N1/10 ,  G01N33/487 ,  A61B5/00 ,  A61B10/00

    Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

    NOVEL METHOD TO MANUFACTURE MICROFIBERS AND MICROCAPILLARIES
    64.
    发明申请
    NOVEL METHOD TO MANUFACTURE MICROFIBERS AND MICROCAPILLARIES 审中-公开

    公开(公告)号：US20190218687A1

    公开(公告)日：2019-07-18

    申请号：US16250963

    申请日：2019-01-17

    Applicant: California Institute of Technology

    Inventor： Tzu-Chieh Chou ,  Yu-Chong Tai ,  Yudan Pi

    IPC: D01F6/96 ,  D01D5/24 ,  D01D10/02

    CPC classification number: D01F6/96 ,  B81B1/00 ,  D01D5/00 ,  D01D5/24 ,  D01D10/02

    Abstract: A parylene microcapillary is manufactured by drawing a polyethylene carbonate (PEC) fiber from a 0° C. solution of 12-25% PEC in chloroform to create a PEC fiber that has a constant diameter over several centimeters. Parylene is deposited in a chamber over the PEC fiber, and then the coated PEC fiber is heated above 180° C. This heating melts and decomposes the PEC fiber such that it self-expels from the coating, leaving a microcapillary. The self-expulsion allows for meters-long lengths of microcapillaries. Alternatively, a serpentine fiber channel of PEC is created by deposition, photolithography, and etching within a sandwich of parylene. It is heated above 180° C. to expel the PEC leaving a hollow channel within a mass of parylene. The resulting microcapillaries may have residues of cyclic ethylene carbonate remaining from the decomposed PEC.

    Substrates for high-density cell growth and metabolite exchange
    67.
    发明授权
    Substrates for high-density cell growth and metabolite exchange 有权

    公开(公告)号：US10053660B2

    公开(公告)日：2018-08-21

    申请号：US15647156

    申请日：2017-07-11

    Applicant: California Institute of Technology ,  City of Hope

    Inventor： Yu-Chong Tai ,  Yang Liu ,  Colin A. Cook ,  Yuman Fong ,  Nanhai G. Chen

    IPC: C12M1/04 ,  C12M1/00

    CPC classification number: C12M23/24 ,  C12M23/14 ,  C12M23/20 ,  C12M25/14 ,  C12M29/04

    Abstract: A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.

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