公开(公告)号：US10709900B2

公开(公告)日：2020-07-14

申请号：US16251973

申请日：2019-01-18

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Michael J. Therien ,  Mark W. Dewhirst ,  Ian N. Stanton ,  Jennifer Ann Ayres ,  Diane Renee Fels ,  Joseph A. Herbert

IPC: A61K41/00 ,  A61N5/06 ,  A61N5/10

Abstract: A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

公开(公告)号：US20190341364A1

公开(公告)日：2019-11-07

申请号：US16515754

申请日：2019-07-18

Applicant: Immunolight, LLC

Inventor： Zakaryae FATHI ,  Frederic A. Bourke, JR. ,  Harold Walder

IPC: H01L23/00 ,  B32B38/00 ,  B32B5/02 ,  B32B7/12 ,  C09J133/00 ,  C09J11/06 ,  B32B7/06 ,  C09J133/06 ,  B32B27/36 ,  B32B27/34 ,  B32B27/32 ,  B32B27/30 ,  B32B27/16 ,  B32B27/08 ,  B32B25/04 ,  B32B21/04 ,  B32B18/00 ,  B32B17/00 ,  B32B9/04 ,  B32B9/02 ,  B32B5/26 ,  B32B5/18 ,  B32B37/12

Abstract: A method of and system for adhesive bonding by a) providing a polymerizable adhesive composition on a surface of an element to be bonded to form an assembly; b) irradiating the assembly with radiation at a first wavelength capable of vulcanization of bonds in the polymerizable adhesive composition by activation of sulfur-containing compound with at least one selected from x-ray, e-beam, visible, or infrared light to thereby generate ultraviolet light in the polymerizable adhesive composition; and c) adhesively joining two or more components together by way of the polymerizable adhesive composition.

公开(公告)号：US20190100680A1

公开(公告)日：2019-04-04

申请号：US16121043

申请日：2018-09-04

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae Fathi ,  Frederic A. Bourke, JR. ,  Harold Walder

IPC: C09J5/00 ,  B32B25/08 ,  B32B7/12 ,  C09J11/04 ,  H01L21/683 ,  H01L23/00 ,  H01L23/29 ,  C09J109/00 ,  C09J107/00 ,  B41J2/175 ,  C09J7/10 ,  C09J121/00 ,  C09J5/02

Abstract: A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.

公开(公告)号：US20180358327A1

公开(公告)日：2018-12-13

申请号：US16103355

申请日：2018-08-14

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae FATHI ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, JR.

IPC: H01L23/00 ,  C09K11/77 ,  A61B17/00 ,  A61L24/06 ,  B32B3/26 ,  B32B7/14 ,  B32B9/04 ,  B32B37/12 ,  B32B37/18 ,  B32B38/00 ,  B41J2/175 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  H01L23/522 ,  H01L25/00 ,  H01L25/065

CPC classification number: H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US20180154178A1

公开(公告)日：2018-06-07

申请号：US15819130

申请日：2017-11-21

Applicant: IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

Inventor： Mark Oldham ,  Justus Adamson ,  Paul Yoon ,  Harold Walder ,  Frederic A. Bourke, JR. ,  Zakaryae Fathi ,  Wayne F. Beyer

IPC: A61N5/10 ,  C09K11/59 ,  C09K11/73 ,  A61K41/00 ,  C09K11/02 ,  A61K31/37 ,  A61P35/00

CPC classification number: A61N5/1031 ,  A61K31/37 ,  A61K41/0057 ,  A61K41/0066 ,  A61K49/0423 ,  A61N5/1077 ,  A61N2005/1034 ,  A61N2005/1098 ,  A61P35/00 ,  C09K11/02 ,  C09K11/595 ,  C09K11/73

Abstract: A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.

公开(公告)号：US09943094B2

公开(公告)日：2018-04-17

申请号：US15290610

申请日：2016-10-11

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic Avery Bourke, Jr. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, Jr.

IPC: A23L3/28 ,  A23L3/26 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  C23C16/458 ,  C02F1/30

CPC classification number: A23L3/28 ,  A23L3/263 ,  A23V2002/00 ,  A61L2/0041 ,  A61L2/0047 ,  A61L2/08 ,  A61L2/082 ,  A61L2202/24 ,  A61M1/3681 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  C02F1/307 ,  C02F1/32 ,  C02F1/325 ,  C02F2201/32 ,  C02F2305/10 ,  C23C16/458 ,  G03F7/20 ,  Y02W10/37

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US09488916B2

公开(公告)日：2016-11-08

申请号：US14206337

申请日：2014-03-12

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic Avery Bourke, Jr. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, Jr.

IPC: G03F7/20 ,  A23L3/26 ,  A23L3/28 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  A61N5/06 ,  A61L2/00 ,  C02F1/30

CPC classification number: A23L3/28 ,  A23L3/263 ,  A23V2002/00 ,  A61L2/0041 ,  A61L2/0047 ,  A61L2/08 ,  A61L2/082 ,  A61L2202/24 ,  A61M1/3681 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  C02F1/307 ,  C02F1/32 ,  C02F1/325 ,  C02F2201/32 ,  C02F2305/10 ,  C23C16/458 ,  G03F7/20 ,  Y02W10/37

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

Abstract translation: 一种用于产生介质变化的方法和系统。 该方法在介质附近放置能量调节剂。 该方法对介质施加引发能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 能量调节剂具有在已知产生变化的第二波长范围（WR2）之外的第一波长范围内的辐射的正常主要发射，但是在暴露于所施加的引发能量的同时产生变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。

公开(公告)号：US20140272030A1

公开(公告)日：2014-09-18

申请号：US14206337

申请日：2014-03-12

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic Avery Bourke, JR. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, JR.

IPC: G21K5/02 ,  A61N5/10 ,  G03F7/20 ,  A23L3/26 ,  C02F1/30 ,  A61M1/36 ,  C02F1/32 ,  A23L3/28 ,  B05D3/06 ,  A61L2/08

CPC classification number: A23L3/28 ,  A23L3/263 ,  A23V2002/00 ,  A61L2/0041 ,  A61L2/0047 ,  A61L2/08 ,  A61L2/082 ,  A61L2202/24 ,  A61M1/3681 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  C02F1/307 ,  C02F1/32 ,  C02F1/325 ,  C02F2201/32 ,  C02F2305/10 ,  C23C16/458 ,  G03F7/20 ,  Y02W10/37

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

Abstract translation: 一种用于产生介质变化的方法和系统。 该方法在介质附近放置能量调节剂。 该方法对介质施加引发能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 能量调节剂具有在已知产生变化的第二波长范围（WR2）之外的第一波长范围内的辐射的正常主要发射，但是在暴露于所施加的引发能量的同时产生变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。