公开(公告)号：US11648750B2

公开(公告)日：2023-05-16

申请号：US16944877

申请日：2020-07-31

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae Fathi ,  Frederic A. Bourke, Jr. ,  Harold Walder

IPC: B32B7/12 ,  B32B27/16 ,  B32B5/02 ,  B32B5/18 ,  B32B5/26 ,  B32B7/06 ,  B32B9/02 ,  B32B9/04 ,  B32B17/00 ,  B32B18/00 ,  B32B21/04 ,  B32B25/04 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B37/12 ,  B32B38/00 ,  C09J11/06 ,  C09J133/00 ,  C09J133/06 ,  H01L23/00 ,  C09J7/10

CPC classification number: B32B7/12 ,  B32B5/02 ,  B32B5/18 ,  B32B5/26 ,  B32B7/06 ,  B32B9/025 ,  B32B9/04 ,  B32B9/043 ,  B32B17/00 ,  B32B18/00 ,  B32B21/042 ,  B32B25/045 ,  B32B27/08 ,  B32B27/16 ,  B32B27/302 ,  B32B27/304 ,  B32B27/308 ,  B32B27/32 ,  B32B27/322 ,  B32B27/34 ,  B32B27/36 ,  B32B37/12 ,  B32B38/0008 ,  C09J7/10 ,  C09J11/06 ,  C09J133/00 ,  C09J133/06 ,  H01L24/00 ,  H01L24/03 ,  H01L24/05 ,  H01L24/29 ,  H01L24/83 ,  B32B2037/1253 ,  B32B2255/26 ,  B32B2305/18 ,  B32B2307/202 ,  B32B2307/204 ,  B32B2307/21 ,  B32B2307/3065 ,  B32B2307/41 ,  B32B2307/412 ,  B32B2307/422 ,  B32B2307/50 ,  B32B2307/546 ,  B32B2307/548 ,  B32B2307/552 ,  B32B2307/706 ,  B32B2307/72 ,  B32B2307/748 ,  B32B2307/75 ,  B32B2310/0806 ,  B32B2439/00 ,  B32B2439/70 ,  B32B2439/80 ,  B32B2457/14 ,  B32B2479/00 ,  B32B2605/003 ,  B32B2605/08 ,  H01L24/27 ,  H01L24/32 ,  H01L24/94 ,  H01L2224/0383 ,  H01L2224/03831 ,  H01L2224/04026 ,  H01L2224/05791 ,  H01L2224/05887 ,  H01L2224/2711 ,  H01L2224/2732 ,  H01L2224/27334 ,  H01L2224/27416 ,  H01L2224/27418 ,  H01L2224/27436 ,  H01L2224/27618 ,  H01L2224/27622 ,  H01L2224/293 ,  H01L2224/2919 ,  H01L2224/2929 ,  H01L2224/29083 ,  H01L2224/29291 ,  H01L2224/29387 ,  H01L2224/32145 ,  H01L2224/32225 ,  H01L2224/32245 ,  H01L2224/32258 ,  H01L2224/83009 ,  H01L2224/83591 ,  H01L2224/83687 ,  H01L2224/83851 ,  H01L2224/83855 ,  H01L2224/83868 ,  H01L2224/83874 ,  H01L2224/94 ,  H01L2924/0569

Abstract: A method of and system for adhesive bonding by a) providing a polymerizable adhesive composition on a surface of an element to be bonded to form an assembly; b) irradiating the assembly with radiation at a first wavelength capable of vulcanization of bonds in the polymerizable adhesive composition by activation of sulfur-containing compound with at least one selected from x-ray, e-beam, visible, or infrared light to thereby generate ultraviolet light in the polymerizable adhesive composition; and c) adhesively joining two or more components together by way of the polymerizable adhesive composition, and a curable polymer for use therein.

公开(公告)号：US10593642B2

公开(公告)日：2020-03-17

申请号：US16252060

申请日：2019-01-18

Applicant: IMMUNOLIGHT, LLC.

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC: H01L23/29 ,  C09J9/02 ,  H01L23/00 ,  C09J11/02 ,  C09J163/00

Abstract: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US10074627B2

公开(公告)日：2018-09-11

申请号：US15455573

申请日：2017-03-10

Applicant: Immunolight, LLC

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC: H01L23/00 ,  H01L25/065 ,  H01L23/522 ,  C09J11/04 ,  C09J11/06 ,  C09J9/02 ,  C09J4/00 ,  B32B7/14 ,  B32B3/26 ,  B32B9/04

CPC classification number: H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US20170319868A1

公开(公告)日：2017-11-09

申请号：US15649917

申请日：2017-07-14

Applicant: IMMUNOLIGHT, LLC. ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, JR. ,  Harold Walder ,  Zakaryae Fathi ,  Michael J. Therien ,  Mark W. Dewhirst ,  Ian N. Stanton ,  Jennifer Ann Ayres ,  Diane Renee Fels ,  Joseph A. Herbert

IPC: A61N5/06 ,  A61N5/10 ,  A61K41/00

CPC classification number: A61N5/062 ,  A61K41/0085 ,  A61N5/0622 ,  A61N5/1077 ,  A61N2005/0661 ,  A61N2005/1091 ,  A61N2005/1098

Abstract: A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

公开(公告)号：US09526914B2

公开(公告)日：2016-12-27

申请号：US14716394

申请日：2015-05-19

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61B5/00 ,  A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

Abstract translation: 用于修改目标结构的产品，组成，系统和方法。 所述方法可以以非侵入性方式进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并施加引发能量，从而产生作用或改变 目标结构直接或通过调制剂。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过施加起始能量来直接地或经由能量调节剂，任选地在一种或多种等离子体激元活性剂的存在下活化可光活化剂，从而对目标结构产生影响或改变。

公开(公告)号：US20140243934A1

公开(公告)日：2014-08-28

申请号：US14168795

申请日：2014-01-30

Applicant: IMMUNOLIGHT, LLC

Inventor： Tuan VO-DINH ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, JR. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61N5/06

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract translation: 用于修改目标结构的产品，组成，系统和方法。 所述方法可以以非侵入性方式进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并施加引发能量，从而产生作用或改变 目标结构直接或通过调制剂。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过施加起始能量来直接地或经由能量调节剂，任选地在一种或多种等离子体激元活性剂的存在下活化可光活化剂，从而对目标结构产生影响或改变。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US11901331B2

公开(公告)日：2024-02-13

申请号：US17647275

申请日：2022-01-06

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC: C08K3/00 ,  H01L23/00 ,  B41J2/175 ,  C09J4/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18 ,  B32B38/00 ,  C09J133/08 ,  C09K11/02 ,  C09K11/77 ,  H01L25/065 ,  H01L25/00 ,  B32B3/26 ,  B32B7/14 ,  B32B9/04 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  H01L23/522

CPC classification number: H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/777 ,  C09K11/7769 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2224/73265 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2924/00 ,  H01L2924/15311 ,  H01L2224/73265 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2924/00 ,  H01L2924/15311 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2224/83192 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2924/07811 ,  H01L2924/00 ,  H01L2924/1461 ,  H01L2924/00 ,  H01L2224/92125 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00 ,  H01L2224/83192 ,  H01L2224/73204 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2924/00

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US11383098B2

公开(公告)日：2022-07-12

申请号：US16516463

申请日：2019-07-19

Applicant: Immunolight, LLC ,  Duke University

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61N5/06 ,  A61K49/00 ,  A61N1/40 ,  A61N5/02 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61K41/00 ,  A61M5/00 ,  A61L2/00 ,  A61L2/08 ,  A61N5/067 ,  A61N5/10

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

公开(公告)号：US11345833B2

公开(公告)日：2022-05-31

申请号：US16121043

申请日：2018-09-04

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae Fathi ,  Frederic A. Bourke, Jr. ,  Harold Walder

IPC: C09J5/00 ,  B32B7/12 ,  B32B25/08 ,  B32B27/28 ,  B32B27/30 ,  B32B27/32 ,  B32B27/36 ,  B41J2/175 ,  C08F2/46 ,  C08F2/48 ,  C08F2/54 ,  C09J5/02 ,  C09J7/10 ,  C09J11/04 ,  C09J107/00 ,  C09J109/00 ,  C09J121/00 ,  H01L21/683 ,  H01L23/29 ,  H01L23/00 ,  C08K3/30

Abstract: A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.

公开(公告)号：US11278042B2

公开(公告)日：2022-03-22

申请号：US17135479

申请日：2020-12-28

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, Jr.

IPC: A23L3/28 ,  A23L3/26 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  A61M1/34 ,  C23C16/458 ,  C02F1/30

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.