公开(公告)号：US20060227653A1

公开(公告)日：2006-10-12

申请号：US10568543

申请日：2004-08-18

Applicant: Wilhelm Keller

Inventor： Wilhelm Keller

IPC: B01F13/06

CPC classification number: B05C17/00509 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2050/0063 ,  A61B2050/0083 ,  A61B2090/037 ,  A61C5/64 ,  A61F2/4601 ,  B01F11/0054 ,  B01F11/0082 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0201 ,  B01F15/0213 ,  B01F15/0226 ,  B01F15/0237 ,  B01F15/0279 ,  B01F2215/0029 ,  B05C17/00506 ,  B05C17/00516 ,  B05C17/00553 ,  B05C17/01 ,  B65D81/325

Abstract: The device for storing, mixing, and dispensing components is provided with means for mixing (6) a first component (27) with a second, liquid component (28) and for dispensing the mixed materials. The individual components (27, 28) are stored in respective containers (2, 3) that are arranged side by side, and a valve assembly (8) is arranged in the transfer area (7) between the outlet area (26) of the container (3) for storing the second, liquid component (28) and the liquid inlet (25) of the container (2) for storing the first component (27). Such a device allows an unproblematic storage of the different components without a local separation of the containers and an efficient mix thereof. This applies especially if the first component is a powder or a granular or porous substance, e.g. bone cement or bone replacement material.

Abstract translation: 用于存储，混合和分配组件的装置设置有用于将第一组分（27）与第二液体组分（28）混合并用于分配混合材料的装置。 各个部件（27,28）被储存在并排设置的相应的容器（2,3）中，并且阀组件（8）布置在传送区域（7）中，位于传送区域（7）的出口区域 用于存储第二部件（28）的容器（3）和容纳第一部件（27）的容器（2）的液体入口（25）。 这样的装置允许不问题地存储不同的部件，而不会容器的局部分离和其有效的混合。 特别是如果第一组分是粉末或颗粒或多孔物质，例如， 骨水泥或骨替代材料。

公开(公告)号：US20060011755A1

公开(公告)日：2006-01-19

申请号：US11175179

申请日：2005-07-07

Applicant: Shigeo Ando ,  Masao Ando ,  Toyoroku Ando

Inventor： Shigeo Ando ,  Masao Ando ,  Toyoroku Ando

IPC: B02C19/00

CPC classification number: B01F5/0663 ,  B01F3/12 ,  B01F15/0201 ,  B01F15/0237 ,  B01F15/0437 ,  B01F2215/0014 ,  B01F2215/0016 ,  B01F2215/0022 ,  B01F2215/0031 ,  B01F2215/0034 ,  B01F2215/0049 ,  B01F2215/0078 ,  B01F2215/0468 ,  C12M47/06 ,  C12M47/08 ,  D21B1/36

Abstract: The present invention relates to a high pressure homogenizing apparatus and a method thereof for finely dividing a fine solid material or fibrous cellulose of chemical, medical, and resin products in a suspension as a dispersion or emulsification, or finely dividing by crushing cell membranes of fungi with high efficiency. The apparatus of the present invention is free from damage of valves so that its maintenance and control become easy. The high pressure homogenizing apparatus to finely divide a raw material in the suspension includes a high pressure homogenizing device having an orifice, a raw material receiving passage connected to the high pressure homogenizing device, a processing piston, and a processing recess disposed in a receiver. A front end of the processing piston is inserted into the processing recess with a pressure intensifier and a volume compression inside the processing recess pressurizes the suspension in the processing recess to lead the suspension into the raw material receiving passage for finely dividing the raw material.

Abstract translation: 本发明涉及一种将悬浮液中的化学，医药和树脂产品的微细固体材料或纤维状纤维素细分为分散体或乳化剂或通过粉碎真菌细胞膜细分的高压均质装置及其方法 效率高。 本发明的装置不会损坏阀门，因此其维护和控制变得容易。 用于将悬浮液中的原料细分的高压均质化装置包括具有孔口，与高压均化装置连接的原料容纳通道，加工活塞和设置在接收器中的处理凹部的高压均质装置。 加工活塞的前端用加压器插入加工凹部，加工凹部内部的体积压缩对加工凹部中的悬浮液加压，将悬浮液引导到原料接收通道中，以细分原料。

公开(公告)号：US06932502B2

公开(公告)日：2005-08-23

申请号：US10137817

申请日：2002-05-01

Applicant: Winthrop D. Childers ,  Mark A. Van Veen ,  Mohammad M Samii ,  Steven W Steinfield

Inventor： Winthrop D. Childers ,  Mark A. Van Veen ,  Mohammad M Samii ,  Steven W Steinfield

IPC: B01F15/04 ,  B01F5/04 ,  B01F13/00 ,  B01F15/00 ,  B01F15/02 ,  C09D7/80

CPC classification number: B01F13/0059 ,  B01F5/0473 ,  B01F15/00207 ,  B01F15/00214 ,  B01F15/0022 ,  B01F15/00227 ,  B01F15/00285 ,  B01F15/00292 ,  B01F15/0201 ,  B01F15/0255 ,  B01F2215/0037 ,  B01F2215/005 ,  B01F2215/0052 ,  B01F2215/0059

Abstract: A mixing apparatus that includes a drop on demand fluid dispenser for adding an additive fluid to a receiver liquid to produce a composite liquid that includes the receiver liquid and the additive fluid.

Abstract translation: 一种混合装置，其包括滴液式流体分配器，用于将添加剂流体添加到接收器液体中以产生包括接收液体和添加剂流体的复合液体。

公开(公告)号：US06899282B1

公开(公告)日：2005-05-31

申请号：US10617373

申请日：2003-07-11

Applicant: Raymond G. Hill

Inventor： Raymond G. Hill

IPC: B01F15/02 ,  B01F15/04 ,  B05B7/26 ,  B05B7/00

CPC classification number: B01F15/0454 ,  B01F15/0201 ,  B01F15/0258 ,  B05B7/26 ,  Y10T137/2516

Abstract: An injection spraying system for mixing additives in controlled amounts to water for spraying, which improves handling and calibrating of the concentration of the mixture. The system includes a water tank, mixing globe, pump device, unloader chamber and a worm reduction element for reducing pumping of one gallon of water into one revolution of a drive shaft. The shaft extends through a clutch device and a plurality of injection chambers. The injection chambers supply and meter the amount of additives injected. Rotation of the shaft through the injection chambers loads a set amount of additives for suction into a mixing globe. The unloader chamber controls the spraying cycle and by-pass cycle of fluid flow through the system. The present invention provides a versatile injection spraying system for multiple tasks. The types and amounts of additives sprayed can be easily adjusted without requiring adjustments to sensitive metering or measuring devices.

Abstract translation: 一种注射喷雾系统，用于将受控量的添加剂与用于喷洒的水混合，这改进了混合物浓度的处理和校准。 该系统包括水箱，混合球，泵装置，卸载室和用于减少将一加仑水泵送到驱动轴一圈的蜗杆减速元件。 轴穿过离合器装置和多个注射室。 注射室供应和计量注入的添加剂的量。 轴通过注射室的旋转将一定量的添加剂加载到混合球中。 卸载室控制流体流过系统的喷涂周期和旁路循环。 本发明提供了一种多用途喷射系统，用于多个任务。 喷涂添加剂的种类和数量可以轻松调整，无需调整敏感计量或测量装置。

公开(公告)号：US06881747B2

公开(公告)日：2005-04-19

申请号：US10429041

申请日：2003-05-05

Applicant: Richard S. Larson ,  Carston R. Wagner

Inventor： Richard S. Larson ,  Carston R. Wagner

IPC: B01F13/00 ,  B01F15/02 ,  C07D233/76 ,  C07D401/12 ,  C07D405/12 ,  C12N5/02 ,  C12P21/04 ,  A61K31/4166 ,  C07D233/02

CPC classification number: C07D401/12 ,  B01F13/0059 ,  B01F13/0093 ,  B01F13/0096 ,  B01F15/0201 ,  B01F15/024 ,  C07D233/76 ,  C07D405/12

Abstract: The present invention provides a compound and a method of making a compound according to the following formula: where R1 is an alkyl group having 1 to 12 carbons; R2 is a urea group; R3 is an active group, such as fluorescein, a toxin, radiolabel or drug; and R4, R5 and R6 are each independently a halide group.

Abstract translation: 本发明提供一种化合物及其制备方法，其中R 1为具有1至12个碳原子的烷基; R 2是尿素基团; R 3 3是活性基团，例如荧光素，毒素，放射性标记物或药物; 和R 4，R 5和R 6各自独立地为卤素基团。

公开(公告)号：US20040259237A1

公开(公告)日：2004-12-23

申请号：US10801460

申请日：2004-03-16

Inventor： Gregory J. Kellogg ,  Charles Able ,  Todd Arnold ,  Bruce L. Carvalho ,  Hsin-Chiang Lin ,  Stephen Kieffer-Higgins ,  Norman F. Sheppard ,  Mikayla Kob ,  Shari Ommert

IPC: C12M001/34

CPC classification number: B01F13/0064 ,  B01F13/0094 ,  B01F15/0201 ,  B01F15/0233 ,  B01F2215/0431 ,  B01F2215/0477 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2300/1827 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N21/4795 ,  G01N35/00069 ,  G01N2035/00237

Abstract: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The invention specifically provides devices and methods for performing miniaturized in vitro amplification assays such as the polymerase chain reaction. Methods specific for the apparatus of the invention for performing PCR are provided.

公开(公告)号：US20040259076A1

公开(公告)日：2004-12-23

申请号：US10601378

申请日：2003-06-23

Applicant: Accella Scientific, Inc.

Inventor： David Farrow

IPC: C12Q001/70

CPC classification number: B82Y30/00 ,  B01D61/18 ,  B01F3/20 ,  B01F3/2057 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0237 ,  B01F2215/0431 ,  B01F2215/045 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/0896 ,  B01L2400/0478 ,  B01L2400/0481 ,  C12Q1/703 ,  G01N1/405 ,  G01N15/1031 ,  G01N33/56988 ,  C12Q2565/501

Abstract: The invention relates to methods and devices for detecting the presence of a particle of interest (hereinafter an analyte particle) in a fluid. A detection device exemplary of the present invention filters a sample of the fluid to remove particles larger than the analyte particles. A reagent solution, containing reagent particles smaller than the analyte particles, is then added to the sample. The reagent particles will react with the analyte particles, if any are present, to form reagent-analyte complexes which are larger than the analyte particles. The sample is then filtered a second time to remove particles the same size as or smaller than the analyte particles. The sample is then tested for the presence of reagent-analyte complexes to detect the presence of the analyte particle in the fluid.

Abstract translation: 本发明涉及用于检测流体中感兴趣的颗粒（以下称为分析物颗粒）的存在的方法和装置。 本发明示例性的检测装置对流体样品进行过滤以除去大于分析物颗粒的颗粒。 然后将含有小于分析物颗粒的试剂颗粒的试剂溶液加入到样品中。 试剂颗粒将与分析物颗粒（如果有的话）反应，形成大于分析物颗粒的试剂 - 分析物复合物。 然后将样品第二次过滤以除去与分析物颗粒相同的尺寸或小于分析物颗粒的颗粒。 然后对样品进行试剂 - 分析物复合物的存在，以检测流体中分析物颗粒的存在。

公开(公告)号：US20040248167A1

公开(公告)日：2004-12-09

申请号：US10801361

申请日：2004-03-15

Inventor： Stephen R. Quake ,  Hou-Pu Chou

IPC: C12M001/34

CPC classification number: B01L3/02 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0072 ,  B01F13/0093 ,  B01F15/0201 ,  B01F15/024 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0418 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0694 ,  C12M1/02 ,  C12Q1/6816 ,  G01N33/53 ,  Y10T137/0318 ,  Y10T137/0329 ,  Y10T137/2218 ,  Y10T137/2224 ,  Y10T436/11 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/2575 ,  C12Q2565/629

Abstract: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

Abstract translation: 本发明涉及用于快速检测与特定疾病相关的DNA，蛋白质或其它分子的微制造装置。 本发明的装置和方法可用于通过检测分子（例如数量的分子），例如多核苷酸（例如DNA）或蛋白质（例如抗体）来同时诊断多种疾病。 与杂交多核苷酸或抗原/抗体复合物相关的报道。 在根据本发明的微制造装置中，分子（即多核苷酸，蛋白质或抗原/抗体复合物）的存在的检测与来自与结合分子相关的光学可检测（例如荧光）报告物的杂交信号相关。 这些杂交信号可以通过任何合适的方式，例如光学检测，并且可以例如存储在计算机中作为特定基因的存在的表示。 杂交探针可以固定在形成一部分或暴露于形成闭环的装置的通道或通道的基底上，用于循环样品以主动接触互补探针。 根据本发明的通用芯片可以不仅用DNA而且可以与其他分子如RNA，蛋白质，肽核酸（PNA）和聚酰胺分子一起制备。

公开(公告)号：US06818435B2

公开(公告)日：2004-11-16

申请号：US09858558

申请日：2001-05-15

Applicant: Bruce L. Carvalho ,  Norman F. Sheppard, Jr. ,  Christina Feakes ,  Gregory J. Kellogg

Inventor： Bruce L. Carvalho ,  Norman F. Sheppard, Jr. ,  Christina Feakes ,  Gregory J. Kellogg

IPC: C12M136

CPC classification number: B01L3/50273 ,  B01F5/0647 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/525 ,  B01L2200/0605 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/10 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0688 ,  B01L2400/088 ,  G01N21/07 ,  G01N35/00069 ,  G01N2035/00495 ,  G01N2035/00504 ,  G01N2035/00514 ,  G01N2035/00524 ,  Y10T436/111666

Abstract: This invention provides methods and apparatus for performing microanalytic analyses and procedures, particularly miniaturized cell based assays. These methods are useful for performing a variety of cell-based assays, including drug candidate screening, life sciences research, and clinical and molecular diagnostics.

Abstract translation: 本发明提供了用于进行微量分析分析和程序，特别是基于小型化的基于细胞的测定的方法和装置。 这些方法对于进行各种基于细胞的测定是有用的，包括药物候选筛选，生命科学研究以及临床和分子诊断。

公开(公告)号：US20040213075A1

公开(公告)日：2004-10-28

申请号：US10851064

申请日：2004-05-24

Applicant: PIRELLI PNEUMATICI S.p.A.

Inventor： Antonio Proni ,  Daniel Balasso ,  Alan Bottomley

IPC: B29B007/88

CPC classification number: B29B7/246 ,  B01F15/00123 ,  B01F15/0201 ,  B01F15/0237 ,  B29B7/183 ,  B29B7/28

Abstract: The invention relates to the processing, in a closed mixer (1), of polymer-based mixtures and compounds for the manufacture of tyres or components thereof. To improve the dispersion of the ingredients in the polymer base, the pressing ram (8) is lowered to the working condition controlling the position thereof over time, in order to compress the ingredients within the mixing chamber (4). The invention is particularly suitable for the dispersion of reinforcing fillers such as silica or carbon black in the polymer base and the incorporation of said fillers in the latter.

Abstract translation: 本发明涉及在密闭混合器（1）中处理聚合物基混合物和用于制造轮胎或其组分的化合物。 为了提高成分在聚合物基体中的分散性，将挤压压头（8）降低到控制其位置的工作状态，以便压缩混合室（4）内的成分。 本发明特别适用于在聚合物基体中分散增强填料如二氧化硅或炭黑，并在后者中加入所述填料。