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公开(公告)号：US20180164214A1
公开(公告)日：2018-06-14
申请号：US15580265
申请日：2016-06-30
Applicant: IMEC VZW
Inventor： Xavier Rottenberg
CPC classification number: G01N21/59 , B01L3/502715 , B01L2300/0816 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , G01N21/31 , G01N21/3577 , G01N21/552 , G01N21/61 , G01N21/7746 , G01N2021/0346 , G01N2021/3137 , G01N2021/3166 , G01N2021/3181 , G01N2201/062 , G01N2201/0633 , G01N2201/0636 , G01N2201/066 , G01N2201/0873
Abstract: The present disclosure relates to a device for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source for emitting light, a plurality of integrated optical waveguides for guiding this light, and a light coupler for coupling the emitted light into the integrated optical waveguides such that the light coupled into each integrated optical waveguide has substantially the same spectral distribution. The device also comprises a microfluidic channel for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide with the fluid in the microfluidic channel. Each integrated optical waveguide comprises an optical resonator for filtering the light guided by the waveguide according to a predetermined spectral component. The spectral component corresponding to each waveguide is substantially different from the spectral component corresponding to another of the waveguides.
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公开(公告)号：US20180113072A1
公开(公告)日：2018-04-26
申请号：US15847758
申请日：2017-12-19
Inventor： Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
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公开(公告)号：US20170212044A1
公开(公告)日：2017-07-27
申请号：US15478982
申请日：2017-04-04
Inventor： Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
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公开(公告)号：US20170176335A1
公开(公告)日：2017-06-22
申请号：US15451305
申请日：2017-03-06
Applicant: Pacific Biosciences of California, Inc.
Inventor： Annette GROT , Ravi SAXENA , Paul LUNDQUIST
IPC: G01N21/64 , H01L27/146 , G02B6/136 , G01N21/77 , G02B6/132
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号：US09606068B2
公开(公告)日：2017-03-28
申请号：US14836629
申请日：2015-08-26
Applicant: Pacific Biosciences of California, Inc.
Inventor： Annette Grot , Ravi Saxena , Paul Lundquist
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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Patent Agency Ranking
公开(公告)号：US20160334334A1
公开(公告)日：2016-11-17
申请号：US15158756
申请日：2016-05-19
Applicant: Pacific Biosciences of California, Inc.
Inventor： Ravi SAXENA , Michael Tzu RU , Takashi Whitney ORIMOTO , Annette GROT , Mathieu FOQUET , Hou-Pu CHOU
CPC classification number: G02B6/12004 , B29D11/0073 , B29D17/007 , B29L2011/005 , B29L2011/0066 , B29L2011/0075 , C12Q1/6869 , G01N21/6454 , G01N21/648 , G01N2021/6478 , G01N2201/0873 , G02B5/189 , G02B6/02123 , G02B6/124 , G02B6/136 , G02B2006/12038 , G02B2006/12109
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
Abstract translation: 提供了集成分析设备阵列及其生产方法。 阵列可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 集成器件允许使用诸如光谱，幅度和时间分辨率之类的特征或其组合来对光信号进行高灵敏度鉴别。 本发明的阵列和方法利用为电子工业开发的硅芯片制造和制造技术，并且非常适合于小型化和高吞吐量。
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67.发明授权公开(公告)号：US09176051B2
公开(公告)日：2015-11-03
申请号：US14129554
申请日：2012-06-23
Applicant: Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
Inventor： Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
CPC classification number: G01N21/27 , G01N2021/7789 , G01N2201/0873 , G02B5/10 , G02B26/00 , H01S3/08059
Abstract: A micro-optical element includes a resonator substrate, at least one microresonator includes a rotationally symmetrical body mounted on the resonator substrate, and a light-reflecting element including a ring-shaped mirror that surrounds the rotationally symmetrical body.
Abstract translation: 微型光学元件包括谐振器基板，至少一个微谐振器包括安装在谐振器基板上的旋转对称的主体，以及包括围绕旋转对称体的环形反射镜的光反射元件。
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公开(公告)号：US20140226160A1
公开(公告)日：2014-08-14
申请号：US14129554
申请日：2012-06-23
Applicant: Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
Inventor： Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
CPC classification number: G01N21/27 , G01N2021/7789 , G01N2201/0873 , G02B5/10 , G02B26/00 , H01S3/08059
Abstract: A micro-optical element includes a resonator substrate, at least one microresonator includes a rotationally symmetrical body mounted on the resonator substrate, and a light-reflecting element including a ring-shaped mirror that surrounds the rotationally symmetrical body.
Abstract translation: 微型光学元件包括谐振器基板，至少一个微谐振器包括安装在谐振器基板上的旋转对称的主体，以及包括围绕旋转对称的主体的环形反射镜的光反射元件。
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公开(公告)号：US20060164635A1
公开(公告)日：2006-07-27
申请号：US11044421
申请日：2005-01-27
Applicant: M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
Inventor： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
CPC classification number: G01N21/658 , G01N2201/0873
Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.
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公开(公告)号：US20050017178A1
公开(公告)日：2005-01-27
申请号：US10788275
申请日：2004-03-01
Applicant: Taro Ogawa , Toshiki Sugawara , Kazuhiko Hosomi , Masataka Shirai , Toshio Katsuyama , Kaoru Umemura , Masaru Izawa , Kazuhiko Sagara , Hiroshi Kakibayashi
Inventor： Taro Ogawa , Toshiki Sugawara , Kazuhiko Hosomi , Masataka Shirai , Toshio Katsuyama , Kaoru Umemura , Masaru Izawa , Kazuhiko Sagara , Hiroshi Kakibayashi
IPC: G01J3/14 , B01J19/00 , B01L3/00 , G01J3/42 , G01N21/05 , G01N21/31 , G01N21/35 , G01N21/3577 , G01N37/00
CPC classification number: G01N21/31 , B01L3/502715 , B01L2200/027 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , G01N21/05 , G01N2021/0346 , G01N2021/058 , G01N2201/0873
Abstract: A micro-spectroscopic measuring device having a structure in which a spectroscopic element made of an array of photonic crystals with defects, flow paths for introducing a sample, and light detecting elements with sensitivity to a band from near infrared to infrared are stacked.
Abstract translation: 具有这样的结构的微分光学测量装置被堆叠，其中由具有缺陷的光子晶体阵列制成的分光元件，用于引入样品的流动路径和对从近红外线到红外线的频带具有灵敏度的光检测元件。
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