公开(公告)号：US09726685B2

公开(公告)日：2017-08-08

申请号：US13269249

申请日：2011-10-07

Applicant: Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jeong-gun Lee

Inventor： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jeong-gun Lee

IPC: B01L3/00 ,  G01N35/00 ,  F16K99/00

CPC classification number: B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

Abstract: Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

公开(公告)号：US09180418B2

公开(公告)日：2015-11-10

申请号：US11751677

申请日：2007-05-22

Applicant: Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

Inventor： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

IPC: B01F11/00 ,  B01F13/00 ,  B01F15/02

CPC classification number: B01F13/0059 ,  B01F11/0002 ,  B01F11/0014 ,  B01F15/0201 ,  B01F15/0233

Abstract: Provided is a method of mixing fluids including introducing at least two kinds of fluids to a chamber of a substrate including a microchannel structure; and alternately rotating the substrate clockwise and counter-clockwise until the at least two kinds of fluids are mixed, wherein the rotation is changed from one direction to the opposite direction before a vortex created in the mixing chamber by the one direction rotation disappears.

Abstract translation: 提供了一种混合流体的方法，包括将至少两种流体引入到包括微通道结构的基板的室中; 并且顺时针和逆时针地交替地旋转衬底，直到混合至少两种流体，其中在通过单向旋转在混合室中产生的涡流消失之前，旋转从一个方向改变到相反的方向。

公开(公告)号：US08652416B2

公开(公告)日：2014-02-18

申请号：US12579484

申请日：2009-10-15

Applicant: Ji Won Kim ,  Beom Seok Lee ,  In Wook Kim ,  Kui Hyun Kim

Inventor： Ji Won Kim ,  Beom Seok Lee ,  In Wook Kim ,  Kui Hyun Kim

IPC: G01N33/52

CPC classification number: G01N33/54366

Abstract: Disclosed are an article for assaying a target, wherein the article includes a solid surface on which a first binding member, a blocking material, and a second binding member are immobilized, a method of manufacturing the article, and a method of detecting a target using the article.

Abstract translation: 公开了一种用于测定靶的制品，其中所述制品包括其上固定有第一结合构件，阻挡材料和第二结合构件的固体表面，制造所述制品的方法，以及使用 文章。

公开(公告)号：US08242433B2

公开(公告)日：2012-08-14

申请号：US12182545

申请日：2008-07-30

Applicant: Suhyeon Kim ,  Jeonggun Lee ,  Beom-seok Lee

Inventor： Suhyeon Kim ,  Jeonggun Lee ,  Beom-seok Lee

IPC: G01D5/34

CPC classification number: B01L3/502715 ,  B01L3/502753 ,  B01L2200/025 ,  B01L2300/02 ,  B01L2300/0627 ,  B01L2300/0806 ,  B01L2300/168 ,  B01L2400/0409 ,  Y10T137/0391 ,  Y10T137/0753

Abstract: Provided are a centrifugal force based platform formed to be rotatable and including a home mark having a retro-reflective property of light, and a centrifugal force based microfluidic system including the platform. The method of determining a home position of the centrifugal force based platform includes: rotating the platform formed and including a home mark having a retro-reflective property of light; emitting light from a light-emitting unit to the platform; and detecting the emitted light, which is retro-reflected by the home mark, in a light-receiving unit, and then determining the home position of the platform based on the detected light.

Abstract translation: 提供了一种基于离心力的平台，其形成为可旋转的，并且包括具有光的反射性能的归位标记，以及包括该平台的基于离心力的微流体系统。 确定基于离心力的平台的起始位置的方法包括：旋转所形成的平台并且包括具有光的回射性能的原点标记; 将发光单元发射到平台; 并且在光接收单元中检测由归属标记反射的发射光，然后基于检测到的光来确定平台的原始位置。

公开(公告)号：US20120028852A1

公开(公告)日：2012-02-02

申请号：US13269411

申请日：2011-10-07

Applicant: Beom-seok LEE ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jeong-gun Lee

Inventor： Beom-seok LEE ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jeong-gun Lee

IPC: C40B60/12

CPC classification number: B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

Abstract: Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

公开(公告)号：US08048387B2

公开(公告)日：2011-11-01

申请号：US12108823

申请日：2008-04-24

Applicant: Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jung-nam Lee

Inventor： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jung-nam Lee

IPC: G01N35/00

CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2200/0684 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2400/0409 ,  B01L2400/06 ,  B01L2400/0677 ,  G01N21/07 ,  Y10T436/111666 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Provided are a centrifugal microfluidic device having a sample distribution structure and a centrifugal microfluidic system including the centrifugal microfluidic device. The centrifugal microfluidic device includes: a rotatable platform; a sample chamber which is disposed in the rotatable platform and houses a fluid sample; a distribution channel connected to an outlet of the sample chamber; a valve which is disposed in the outlet of the sample chamber; a plurality of non-vented reaction chambers which are disposed in the rotatable platform outside of the distribution channel in the radial direction; and a plurality of inlet channels connecting the distribution channel with the reaction chambers.

Abstract translation: 提供了具有样品分布结构和包括离心微流体装置的离心微流体系统的离心微流体装置。 离心微流体装置包括：可旋转平台; 样品室，其设置在所述可旋转平台中并容纳流体样品; 连接到样品室的出口的分配通道; 设置在样品室的出口的阀; 多个非排气反应室，其在径向上设置在分配通道外部的可旋转平台内; 以及将分配通道与反应室连接的多个入口通道。

公开(公告)号：US20110232832A1

公开(公告)日：2011-09-29

申请号：US13157535

申请日：2011-06-10

Applicant: Jong-myeon PARK ,  Yoon-kyoung CHO ,  Beom-seok LEE ,  Jeong-gun LEE

Inventor： Jong-myeon PARK ,  Yoon-kyoung CHO ,  Beom-seok LEE ,  Jeong-gun LEE

IPC: B21K1/20 ,  H05B6/10 ,  B32B37/00

CPC classification number: F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0084 ,  Y10T29/49412 ,  Y10T137/2191 ,  Y10T137/2196

Abstract: Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves.

Abstract translation: 本发明提供一种微流体阀，微流体阀的制造方法和采用该微流体阀的微流体装置。 该微流体阀包括一个平台，该平台包括彼此相结合的两个基板; 具有允许流体在两个基板之间流动的第一深度的通道; 阀间隙，其设置在所述通道的至少一个区域上，并且具有小于所述第一深度的第二深度; 以及阀塞，其设置成填充阀间隙，并且由阀室材料形成，所述阀门材料是通过将在室温下为固体的相变材料与多个放出足以熔化的 相变材料通过吸收电磁波。

公开(公告)号：US20110201101A1

公开(公告)日：2011-08-18

申请号：US13035654

申请日：2011-02-25

Applicant: Beom Seok LEE ,  Yoon Kyoung CHO ,  Jeong Gun LEE ,  Jong Myeon PARK

Inventor： Beom Seok LEE ,  Yoon Kyoung CHO ,  Jeong Gun LEE ,  Jong Myeon PARK

IPC: C12M1/34 ,  G01N9/30

CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54326 ,  G01N33/54366 ,  Y10T436/25375

Abstract: Disclosed is a microfluidic structure and a microfluidic device comprising the microfluidic device, which is suitable for detecting a target material. The microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

Abstract translation: 公开了一种微流体结构和包含微流体装置的微流体装置，其适合于检测目标材料。 微流体结构混合珠，生物样品和检测探针，以在反应后反应并洗涤和分离珠粒。

公开(公告)号：US20110124132A1

公开(公告)日：2011-05-26

申请号：US12894683

申请日：2010-09-30

Applicant: In Wook KIM ,  Beom Seok LEE ,  Kui Hyun KIM ,  Ji Won KIM

Inventor： In Wook KIM ,  Beom Seok LEE ,  Kui Hyun KIM ,  Ji Won KIM

IPC: G01N33/553 ,  G01N30/00 ,  B01L3/00 ,  C12M1/34 ,  G01N27/00 ,  G01N21/00 ,  G01N21/76

CPC classification number: G01N21/07 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N33/54313 ,  G01N33/54346 ,  G01N35/00069

Abstract: Disclosed are a centrifugal micro-fluidic device and an immunosorbent assay method using the same. In particular, a centrifugal micro-fluidic device having a plurality of micro-fluidic structures placed in a disc type platform to simultaneously conduct several immunosorbent assays, as well as an immunosorbent assay method using the same are provided.

Abstract translation: 公开了一种使用其的离心微流体装置和免疫吸附测定方法。 特别地，提供了具有多个微流体结构的离心微流体装置，其放置在盘型平台中以同时进行几种免疫吸附测定，以及使用其的免疫吸附测定方法。

公开(公告)号：US20110091356A1

公开(公告)日：2011-04-21

申请号：US12884762

申请日：2010-09-17

Applicant: Kui Hyun KIM ,  Beom Seok LEE ,  In Wook KIM ,  Ji Won KIM ,  Yang Ui LEE

Inventor： Kui Hyun KIM ,  Beom Seok LEE ,  In Wook KIM ,  Ji Won KIM ,  Yang Ui LEE

IPC: G01N33/00

CPC classification number: F16K99/003 ,  B01L3/502738 ,  B01L2300/0803 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0084

Abstract: A micro-fluidic device containing an anti-coagulant and a sample testing apparatus equipped with the same are provided. The micro-fluidic device includes a sample chamber which receives a sample, an anti-coagulant chamber which receives an anti-coagulant, a channel which communicably connects the sample chamber to the anti-coagulant chamber, and a valve which opens and closes the channel.

Abstract translation: 提供含有抗凝剂的微流体装置和装备有该装置的样品测试装置。 微流体装置包括容纳样品的样品室，接收抗凝剂的抗凝剂室，将样品室与抗凝剂室可通信地连接的通道和打开和关闭通道的阀 。