公开(公告)号：US20150182549A1

公开(公告)日：2015-07-02

申请号：US14408495

申请日：2013-06-24

Applicant: Glycom A/S

Inventor： Elise Champion ,  Dóra Molnár-Gábor ,  Gyula Dekany

IPC: A61K31/715 ,  A23L1/30 ,  A23L1/29

CPC classification number: A61K31/715 ,  A23L29/275 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/00 ,  C07H9/06 ,  C07H13/04 ,  C12P19/00 ,  C12P19/18 ,  C12P19/26 ,  C12Y302/01038 ,  C12Y302/01051 ,  A23V2200/304 ,  A23V2200/3202 ,  A23V2200/324 ,  A23V2250/28

Abstract: A method for modifying galactosyl disaccharides in order to enhance their bifidogenic effect, comprising reacting at least one glycosyl donor with a precursor galactosyl disaccharide or a mixture of precursor galactosyl disaccharides using enzyme catalysis, compounds obtainable by said method and the use of such compounds in consumable products.

Abstract translation: 一种用于改善半乳糖二糖以增强其双发效应的方法，包括使用酶催化使至少一种糖基供体与前体半乳糖二糖或前体半乳糖二糖的混合物反应，可通过所述方法获得的化合物和这些化合物在消耗品中的用途 产品。

公开(公告)号：US12233079B2

公开(公告)日：2025-02-25

申请号：US17417029

申请日：2019-12-19

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K9/00 ,  A61K9/16 ,  A61K9/48 ,  A61K35/20 ,  A61K47/24 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61P1/14

Abstract: A synthetic composition and method for use in providing a source of oligosaccharides to a human consuming a low-FODMAP diet, increasing the abundance of bifidobacteria in the colon of a human consuming a low-FODMAP diet, and/or reintroducing FODMAPs into the diet of a human consuming a low-FODMAP diet. The composition contains one or more human milk oligosaccharides.

公开(公告)号：US12054513B2

公开(公告)日：2024-08-06

申请号：US18057360

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin Podányi ,  Pierre Chassagne ,  Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A23L33/00 ,  C07H1/00 ,  C07H3/02

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H3/02 ,  A23L33/40

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20240124509A1

公开(公告)日：2024-04-18

申请号：US18257979

申请日：2021-12-17

Applicant: GLYCOM A/S

Inventor： Martin MATWIEJUK

IPC: C07H7/033 ,  B01D15/36 ,  B01J41/07 ,  C07H1/06

CPC classification number: C07H7/033 ,  B01D15/363 ,  B01J41/07 ,  C07H1/06

Abstract: The present invention concerns a method for separating different oligosaccharides having at least one carboxylic acid group by contacting them with basic anion exchange resins.

公开(公告)号：US20240101587A1

公开(公告)日：2024-03-28

申请号：US18257986

申请日：2021-12-17

Applicant: Glycom A/S

Inventor： Nikolay KHANZHIN ,  Marco WIESER ,  Jesper THØGERSEN

IPC: C07H1/06 ,  C07H3/06

CPC classification number: C07H1/06 ,  C07H3/06

Abstract: Disclosed herein are systems and methods for the purification of human milk oligosaccharides (HMOs). The HMOs can be purified from a suspension containing one or more of a bacterial biomass, cell fragments, small particles, and biomolecules. Advantageously, the solution can be pre-treated prior to centrifuging to form a clarified supernatant containing purified HMOs.

公开(公告)号：US11896605B2

公开(公告)日：2024-02-13

申请号：US17353749

申请日：2021-06-21

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC: A61K31/702 ,  A61K31/706 ,  A61P1/00 ,  A61K31/7016

CPC classification number: A61K31/702 ,  A61K31/7016 ,  A61P1/00

Abstract: This disclosure relates generally to compositions and methods for preventing or treating mast cell mediated visceral pain.

公开(公告)号：US20240043891A1

公开(公告)日：2024-02-08

申请号：US18258770

申请日：2021-12-21

Applicant: GLYCOM A/S

Inventor： Margit PEDERSEN

IPC: C12P19/18 ,  C12N9/10

CPC classification number: C12P19/18 ,  C12N9/1051 ,  C12Y204/01069 ,  C12Y204/01065

Abstract: The present invention relates to a genetically modified cell expressing an α-1,2-fucosyltransferase and an α-1,3-fucosyltransferase, and a transporter protein of the major facilitator superfamily (MFS) and to a method for recombinant production of human milk oligosaccharides (HMOs) using said genetically modified cell. More particularly, the invention provides a method for recombinant production of and a genetically modified cell capable of producing difucosyllactose (DFL) as the most abundant HMO, with a relatively low content of 3-fucosyllactose (3FL) and/or 2′-fucosyllactose (2′FL).

公开(公告)号：US20240043889A1

公开(公告)日：2024-02-08

申请号：US18550209

申请日：2022-03-11

Applicant: Glycom A/S

Inventor： Getachew S. MOLLA

IPC: C12P19/04 ,  C07H1/08 ,  C12N9/10

CPC classification number: C12P19/04 ,  C07H1/08 ,  C12N9/1048 ,  C12Y204/00

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US20230193335A1

公开(公告)日：2023-06-22

申请号：US17759270

申请日：2021-01-22

Applicant: GLYCOM A/S

Inventor： Margit PEDERSEN ,  Manos PAPADAKIS ,  Katrine Bych KAMPMANN

IPC: C12P19/04 ,  C12N9/10 ,  C12N15/70 ,  C07K14/24

CPC classification number: C12P19/04 ,  C12N9/1051 ,  C12Y204/01065 ,  C12Y204/01146 ,  C12N15/70 ,  C07K14/24

Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic encoding a putative transporter protein of the MFS superfamily; and methods using said cell for the production of oligosaccharide(s), preferably an HMO.

公开(公告)号：US11602545B2

公开(公告)日：2023-03-14

申请号：US16770336

申请日：2018-11-30

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61P25/06 ,  A61K31/702 ,  A61P1/00 ,  A61K35/20

Abstract: The invention relates to a human milk oligosaccharide (HMO) for use in, a synthetic composition comprising an HMO for use in and a method for preventing or treating migraine in a human.