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    METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE
    5.
    发明申请
    METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE 审中-公开
    从D-葡萄糖制备L-赖氨酸前体的方法

    公开(公告)号：US20140235848A1

    公开(公告)日：2014-08-21

    申请号：US14348014

    申请日：2012-09-28

    Applicant: Glycom A/S

    Inventor： Julien BOUTET ,  Nikolay KHANZHIN ,  Filippo BONACCORSI ,  Gyula DEKANY

    IPC: C07H9/02 ,  C07H13/04 ,  C07H11/00 ,  C07H13/08

    CPC classification number: C07H9/02 ,  C07H1/00 ,  C07H3/02 ,  C07H9/04 ,  C07H11/00 ,  C07H13/04 ,  C07H13/08 ,  Y02P20/55

    Abstract: A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d), formula (a), (b), (c) or (d) or wherein R1 is OH, and Q is a group (e), (f) or (g); formula (e), (f) or (g) wherein R2 is acyloxy and R3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step a), wherein the moiety is a highly lipophilic protecting group; compounds according to formula (1), and use of a compound according to formula (1) are provided.

    Abstract translation: 一种可用于从D-葡萄糖制备L-岩藻糖的前体的方法，其包括以下步骤：a）从D-葡萄糖制备式（1）化合物，式（1）其中R1为酰氧基，Q为 （a），（b），（c）或（d），式（a），（b），（c）或（d）或其中R 1是OH，Q是基团（e） f）或（g）; 式（e），（f）或（g）其中R 2是酰氧基，R 3是磺酰基离去基团; 和b）从步骤a）中形成的式（1）化合物生产6-脱氧-L-托洛糖，其中所述部分是高亲脂性保护基; 提供了式（1）化合物和使用式（1）化合物。

    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES
    9.
    发明申请
    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES 有权
    异亮氨酸/ FOSOSLIL人乳酪寡糖的合成

    公开(公告)号：US20160075729A1

    公开(公告)日：2016-03-17

    申请号：US14783783

    申请日：2014-04-11

    Applicant: GLYCOM A/S

    Inventor： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Markus HEDEROS ,  Elise CHAMPION ,  Martin MATWIEJUK ,  Gyula DEKANY

    IPC: C07H5/04

    CPC classification number: C07H5/04 ,  C07H1/00

    Abstract: An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

    Abstract translation: 其中R选自-OH，-N 3和-OR 6，其中R 6选自任选被一个或多个甲基取代的烯丙基，炔丙基任选被一个或多个甲基， 三甲基甲硅烷基 - 乙基， - （CH 2）n -NH 2和 - （CH 2）n -N 3其中整数n为10，优选2或3，R选自唾液酰基部分，-SO 3 H和-CH（R）-COOH，其中R 选自H，烷基和苄基，R2选自H和岩藻糖基，R3选自H和唾液烷基，R4选自H和岩藻糖基，条件是R3和R4中至少一个为H，A为二价 碳水化合物接头，对制药和食品工业具有重要的生物活性和显着的商业价值。

    BIOMASS REMOVAL BY CENTRIFUGATION
    10.
    发明公开
    BIOMASS REMOVAL BY CENTRIFUGATION 审中-公开

    公开(公告)号：US20240101587A1

    公开(公告)日：2024-03-28

    申请号：US18257986

    申请日：2021-12-17

    Applicant: Glycom A/S

    Inventor： Nikolay KHANZHIN ,  Marco WIESER ,  Jesper THØGERSEN

    IPC: C07H1/06 ,  C07H3/06

    CPC classification number: C07H1/06 ,  C07H3/06

    Abstract: Disclosed herein are systems and methods for the purification of human milk oligosaccharides (HMOs). The HMOs can be purified from a suspension containing one or more of a bacterial biomass, cell fragments, small particles, and biomolecules. Advantageously, the solution can be pre-treated prior to centrifuging to form a clarified supernatant containing purified HMOs.

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