Evaporation-limiting inserts for reagent containers and related methods of use

    公开(公告)号:US10799870B2

    公开(公告)日:2020-10-13

    申请号:US15910641

    申请日:2018-03-02

    Abstract: An insert for a liquid-holding container may include a body comprising a wall, open first and second ends, and a lumen extending from the open first end to the open second end. The insert also may include a plurality of first openings formed in the wall, the first openings being situated between the first and second ends, and each of the first openings defining an area, and one or more second openings formed in the wall, the one or more second openings being situated between the first and second ends, each of the one or more second openings defining an area that is greater than the area defined by any of the first openings, where at least one of the one or more second openings is situated closer to the first end than any of the first openings, and wherein each of the first and second openings is sized to permit the passage of a liquid.

    Apparatus for maintaining a controlled environment

    公开(公告)号:US10443935B2

    公开(公告)日:2019-10-15

    申请号:US15745834

    申请日:2016-08-02

    Inventor: Byron J. Knight

    Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

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