公开(公告)号：US20240426718A1

公开(公告)日：2024-12-26

申请号：US18825395

申请日：2024-09-05

Applicant: PRIME23 GMBH

Inventor： Xaver EINSLE

IPC: G01N1/31 ,  B01L1/02 ,  B01L3/00

Abstract: This disclosure relates to a device configured to wet a biological material with at least one liquid, and a disclosed method relates to wetting biological material with at least one liquid using the disclosed device. A disclosed device includes a moving arrangement and a platform configured to receive at least one, substantially triangular or substantially rectangular slide comprising a biological material. The slide is configured to be movable by the moving arrangement from a parallel incubating position, relative to said platform, into a non-parallel collecting position, relative to said platform. Only a single corner section of slide is positioned such that said liquid is collected in the single corner section. Introducing reagents into a mixing zone of said device and repeatedly moving the slide from the collecting position into a mixing position causes mixing of the reagents to thereby generate the liquid that is configured to wet the biological material.

公开(公告)号：US12172300B2

公开(公告)日：2024-12-24

申请号：US17692029

申请日：2022-03-10

Applicant: UCHICAGO ARGONNE, LLC

Inventor： Daniel R. Dilday, Jr. ,  Roberto T. Reyes ,  Stanley Weidmeyer

IPC: B25J21/02 ,  B01L1/02 ,  G21F7/04 ,  G21F7/047

Abstract: The invention provides a system for preventing fluid exchange between the interior and exterior of containment enclosures such as process-, hazard-, and research-enclosure systems generally, gloveboxes, containment systems, isolation systems, confinement systems, cleanrooms, negative air systems, and positive air system areas while simultaneously providing material transfer into and out of the enclosures. The invention also provides a method for transporting material into or out of a containment structure.

公开(公告)号：US12128415B2

公开(公告)日：2024-10-29

申请号：US17195206

申请日：2021-03-08

Applicant: Pattern Bioscience, Inc.

Inventor： Ross Johnson ,  Jonathan Isom ,  David Bussian ,  Nicolas Arab

IPC: B01L9/00 ,  B01L1/02 ,  B01L3/00 ,  G01N21/31

CPC classification number: B01L9/527 ,  B01L1/02 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502784 ,  G01N21/31 ,  B01L2200/0642 ,  B01L2200/0647 ,  B01L2300/0663 ,  B01L2400/049

Abstract: An apparatus for loading and imaging a microfluidic chip can comprise a housing having walls that define a vacuum chamber and a first receptacle disposed within the vacuum chamber, the first receptacle defining a space for receiving one or more microfluidic chips. The apparatus can also include a negative pressure source, a light source, and an optical sensor coupled to the housing. The negative pressure source can be configured to reduce pressure within the vacuum chamber, the light source can be positioned to illuminate at least a portion of the space for receiving the chip(s), and the optical sensor can be positioned to capture an image of at least a portion of the space for receiving the chip(s).

公开(公告)号：US12111329B2

公开(公告)日：2024-10-08

申请号：US17691258

申请日：2022-03-10

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Christopher A. Procyshyn ,  Marcin Cichy

IPC: G01N1/00 ,  A61J1/12 ,  A61J1/14 ,  A61J1/20 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  B01L1/02 ,  B01L1/04 ,  B01L3/02 ,  B25J21/00 ,  B65B3/00 ,  B65B3/04 ,  B65B55/12 ,  C12M1/00 ,  C12M1/12 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N35/10 ,  A61J1/12 ,  A61J1/14 ,  A61J1/20 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  B01L1/025 ,  B01L1/04 ,  B01L3/02 ,  B25J21/00 ,  B65B3/003 ,  B65B3/04 ,  B65B55/12 ,  C12M29/00 ,  C12M37/02 ,  C12M41/14 ,  G01N35/00029 ,  G01N35/0099 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2400/0487 ,  G01N2035/00148 ,  G01N2035/00277

Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

公开(公告)号：US12105106B2

公开(公告)日：2024-10-01

申请号：US17294352

申请日：2018-11-16

Applicant: AIXINNO LIMITED

Inventor： Patrick Clemente Gilligan ,  Kenneth B. K. Teo ,  David Anthony Bullinaria

IPC: G06F7/00 ,  B01L1/02 ,  B65G49/00 ,  C12M3/00 ,  G01N35/02 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N35/025 ,  B01L1/02 ,  C12M23/44 ,  B01L2200/028 ,  B01L2200/141 ,  B01L2300/0829 ,  C12M23/48 ,  G01N2035/00326 ,  G01N2035/0418 ,  G01N2035/0465

Abstract: A process module for a biology laboratory system includes a housing, a working deck located within the housing, having working deck plate slots for receiving cell culture plates, a liquid handling robot comprising at least one pipette for aspirating a liquid medium, and a first transfer interface in communication with a first storage module for storing cell culture plates. The working deck is movable to a plurality of working positions. In one of the positions, the cell culture plate is located under an operating point of the liquid handling robot. In another of the positions, the cell culture plate is in alignment with the first transfer interface for transfer of the cell culture plate between an outside of the housing and the working deck plate slot. The first transfer interface or a second interface can be brought in communication with a second storage module for storing lab-ware or liquid material.

公开(公告)号：US20240286124A1

公开(公告)日：2024-08-29

申请号：US18573430

申请日：2022-06-24

Applicant: Andreas Hettich GmbH & Co. KG

Inventor： Ulrich MASSING

IPC: B01L1/02 ,  B01L9/06

CPC classification number: B01L1/025 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/08

Abstract: A device for treating samples in sample containers under vacuum comprises a housing, a vacuum chamber arranged in the housing and interacting with a vacuum pump, a cover via which the vacuum chamber is closed in vacuum-tight manner and opened to load and unload sample containers, a sample holder with a base surface and a plurality of sample container receptacles for receiving sample containers. A sample holder axis runs perpendicular to the base surface of the sample holder, a drive unit mounted in the vacuum chamber and connected to the sample holder drives the sample holder about the sample holder axis, and a drive mechanism is arranged outside the vacuum chamber and drivingly coupled to the drive unit. The sample holder axis is aligned at specified fixed acute holder angle (β) relative to a longitudinal axis of a safety vessel which delimits the vacuum chamber in certain regions.

公开(公告)号：US20240189809A1

公开(公告)日：2024-06-13

申请号：US17615969

申请日：2021-06-15

Applicant: Hitachi Industrial Equipment Systems Co., Ltd.

Inventor： Takeshi MATSUMURA ,  Takeshi KANEKO

IPC: B01L1/02 ,  B01L1/00

CPC classification number: B01L1/02 ,  B01L1/50 ,  B01L2200/082 ,  B01L2200/085

Abstract: A safety cabinet has an opening portion in the front surface of a work room and a front shutter and supplies clean air to the work room from above. A side slit is provided in the side surface of the work room, air from the provided side slit joins an air flow path suctioned from a front grille of a workbench forming the bottom surface of the work room, and the turbulence of an airstream can be prevented even when a device is installed in the work room.

公开(公告)号：US11980881B2

公开(公告)日：2024-05-14

申请号：US17887667

申请日：2022-08-15

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Marcin Cichy ,  Juvenal Naing ,  Carlos Alberto Diaz Guerrero

IPC: B01L1/02 ,  A61J1/12 ,  A61J1/14 ,  A61J1/20 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  B01L1/04 ,  B01L3/02 ,  B25J21/00 ,  B65B3/00 ,  B65B3/04 ,  B65B55/12 ,  C12M1/00 ,  C12M1/12 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L1/025 ,  A61J1/12 ,  A61J1/14 ,  A61J1/20 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  B01L1/04 ,  B01L3/02 ,  B25J21/00 ,  B65B3/003 ,  B65B3/04 ,  B65B55/12 ,  C12M29/00 ,  C12M37/02 ,  C12M41/14 ,  G01N35/00029 ,  G01N35/10 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2400/0487 ,  G01N2035/00148 ,  G01N2035/00277 ,  G01N35/0099

Abstract: The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.

公开(公告)号：US11874288B1

公开(公告)日：2024-01-16

申请号：US16247925

申请日：2019-01-15

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Richard C. Sharp ,  Frederick Milton Blodgett, Jr. ,  Vlorent Morina ,  Jerry E. Hurst, Jr.

IPC: B01L3/00 ,  G01N35/00 ,  B01L7/00 ,  B01L5/00 ,  B01L1/02

CPC classification number: G01N35/00732 ,  B01L1/02 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/565 ,  B01L5/00 ,  B01L7/54 ,  B01L2200/146 ,  B01L2300/048 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/1805 ,  B01L2300/1833

Abstract: A well plate includes a frame section that defines a plane, and a plurality of well structures. Each well structure extends in a direction away from the plane defined by the frame section, and each well structure defines a well for holding a fluid. The well plate further includes an artifact connected to at least one well structure. The artifact uniquely identifies a type of the well plate among other types of well plates. Along these lines, a result of a well plate type identification operation, which indicates whether the well plate includes the artifact, may determine whether a predefined pressure is applied to the well plate to facilitate fluid sampling in response to the result, whether fluid level sensing can be performed to gauge amounts of fluids drawn from the wells and/or identify how much fluid is left in the wells, etc.

公开(公告)号：US20230415142A1

公开(公告)日：2023-12-28

申请号：US18038397

申请日：2021-11-29

Applicant: CYTENA BIOPROCESS SOLUTIONS CO., LTD

Inventor： Cheng-Han TSAI ,  Da-Han KUAN ,  Cheng-Yu JIANG

IPC: B01L1/02 ,  B01L3/00 ,  C12M1/00 ,  G01N21/80

CPC classification number: B01L1/02 ,  B01L3/5027 ,  C12M29/14 ,  G01N21/80 ,  B01L2200/028 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/06

Abstract: The invention relates to a control unit for a fluid control device wherein the control unit comprises a pressure unit for providing positive and/or negative pressure, at least one first control unit outlet being fluidically connectable to a processing device comprising at least one receptacle for receiving a fluid sample, at least one second control unit outlet being fluidically connectable to a treatment device having a chamber for receiving the processing device, and a connection unit by means of which the pressure unit is fluidically connectable or connected with the first control unit outlet and/or with the second control unit outlet wherein the control unit is adapted to control the processing of the fluid sample in the processing device by applying a positive or negative pressure provided by the pressure unit to the first control unit outlet by means of the connection unit and to control a physical state in the chamber of the treatment device.