公开(公告)号：US09772276B2

公开(公告)日：2017-09-26

申请号：US15304359

申请日：2015-05-13

Applicant: Konica Minolta, Inc.

Inventor： Akihiro Fujimoto

IPC: G01N21/35 ,  G01N21/3581 ,  G01N21/3586

CPC classification number: G01N21/3581 ,  G01N21/3586 ,  G01N2201/061 ,  G01N2201/066

Abstract: A detection device having: a terahertz wave generation element; a terahertz wave detection element; a first transmission path arranged upon the terahertz wave generation element; a second transmission path arranged upon the terahertz wave detection element; and a sealed section arranged between the terahertz wave generation element and the terahertz wave detection element and separated from the first transmission path and the second transmission path, so as to surround the first transmission path and the second transmission path. A space between an emission surface in the first transmission path and an incident surface in the second transmission path is connected to a space between the first transmission path and the sealed section and to a space between the second transmission path and the sealed section.

公开(公告)号：US09518925B2

公开(公告)日：2016-12-13

申请号：US14367353

申请日：2012-12-21

Applicant: RADISENS DIAGNOSTICS LTD.

Inventor： Donal Cronin ,  Jerry O'Brien ,  Lee Barry

IPC: G01N21/64 ,  G01J1/04 ,  G01J1/18 ,  G01J3/36 ,  G01N21/76 ,  G01J3/12 ,  G01N15/14

CPC classification number: G01N21/6486 ,  G01J1/0418 ,  G01J1/0492 ,  G01J1/18 ,  G01J3/36 ,  G01J2003/1213 ,  G01N15/14 ,  G01N15/1484 ,  G01N21/645 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/066 ,  G01N2201/12

Abstract: The invention provides a high resolution, wide dynamic range, multi-color detection platform for microfluidic analyzers/instruments and methods. The detection platform uses multiple high gain semiconductor optical sensors for the detection of luminescence from cellular or biological samples. The digitized outputs from these sensors are combined and weighted in a signal processing unit, using pre-determined algorithms for each color, which optimize the resolution in each of these high gain semiconductor optical sensors while extending the dynamic range of the detection platform.

Abstract translation: 本发明提供了用于微流控分析仪/仪器和方法的高分辨率，宽动态范围的多色检测平台。 检测平台使用多个高增益半导体光学传感器来检测来自细胞或生物样品的发光。 来自这些传感器的数字化输出在信号处理单元中被组合和加权，使用用于每种颜色的预定算法，其优化每个这些高增益半导体光学传感器中的分辨率，同时延长检测平台的动态范围。

公开(公告)号：US09500584B2

公开(公告)日：2016-11-22

申请号：US14125093

申请日：2012-06-25

Applicant: Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

Inventor： Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

IPC: G01N21/00 ,  G01N21/59 ,  G01N21/03 ,  G01N21/31 ,  G01N21/552 ,  G01N33/543 ,  G01N21/17

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: An apparatus for examination of a sample includes at least one sample chamber in which the sample can be provided, where the sample chamber has a detection surface; at least one light source for emitting a first input light beam which is totally internally reflected at the detection surface of the sample chamber into a first output light beam, and for emitting a second input light beam which is at least partially transmitted through the sample chamber into a second output light beam. The apparatus further includes at least one light detector for detecting the first and the second output light beams. The sample chamber is elongated and traversed in longitudinal direction by light of the second input light beam.

Abstract translation: 用于检查样品的装置包括至少一个样品室，其中可以提供样品，其中样品室具有检测表面; 至少一个光源，用于发射在样品室的检测表面处完全内部反射到第一输出光束中的第一输入光束，并且用于发射至少部分透射通过样品室的第二输入光束 进入第二输出光束。 该装置还包括至少一个用于检测第一和第二输出光束的光检测器。 样品室通过第二输入光束的光线在纵向方向上被细长并横越。

公开(公告)号：US09366622B2

公开(公告)日：2016-06-14

申请号：US14380685

申请日：2013-02-22

Applicant: Damien Weidmann

Inventor： Damien Weidmann

IPC: G01N21/49 ,  G01S17/32 ,  G01S17/95 ,  G01S7/491 ,  B82Y20/00 ,  G01N33/00 ,  H01S5/022 ,  H01S5/34 ,  H01S5/024

CPC classification number: G01N21/49 ,  B82Y20/00 ,  G01N33/0027 ,  G01N2201/06113 ,  G01N2201/0636 ,  G01N2201/066 ,  G01S7/4911 ,  G01S17/32 ,  G01S17/95 ,  H01L2924/0002 ,  H01S5/02264 ,  H01S5/02415 ,  H01S5/02469 ,  H01S5/3401 ,  Y02A90/19 ,  H01L2924/00

Abstract: An active heterodyne detection system comprises a continuously tuneable laser source (1) emitting infra-red radiation, means (8) to split the infra-red radiation into a first part and a second part, means (4) to provide a frequency shift between the first part and the second part, means (8, 9) to direct the first part of the infra-red radiation to a target (2), means (4) to provide the second part of the infra-red radiation as a local oscillator, means (8, 9) to collect a scattered component of the first part of the infra-red light from the target (2), and means (5) to mix the scattered component and the local oscillator and route them to a detector (3) for heterodyne detection over a continuous spectral range. A method of active heterodyne detection over a continuous spectral range is also disclosed.

Abstract translation: 主动外差检测系统包括发射红外辐射的可连续调谐的激光源（1），用于将红外辐射分裂成第一部分和第二部分的装置（8），用于在第二部分和第二部分之间提供频移 第一部分和第二部分是将红外辐射的第一部分引导到目标（2）的装置（8,9），装置（4）将红外辐射的第二部分提供为局部 振荡器，用于收集来自目标（2）的红外光的第一部分的散射分量的装置（8,9），以及用于将散射分量和本地振荡器混合并将其路由到检测器的装置（5） （3）用于连续光谱范围的外差检测。 还公开了在连续光谱范围内的主动外差检测方法。

公开(公告)号：US20140231680A1

公开(公告)日：2014-08-21

申请号：US14174964

申请日：2014-02-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Darko Klinec

IPC: G01N33/49

CPC classification number: G01N33/491 ,  G01N15/06 ,  G01N21/13 ,  G01N21/253 ,  G01N21/3151 ,  G01N21/51 ,  G01N35/02 ,  G01N35/1016 ,  G01N2015/045 ,  G01N2015/0693 ,  G01N2035/0406 ,  G01N2035/1018 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: A method for detecting clots in a liquid is presented. The liquid is in a sample container. Light is irradiated having a first wavelength to the sample container by a first light source at a changeable vertical irradiating position (P—0 to P_n) such that the light irradiated by the first light source passes through the sample container along a first measurement path. An intensity of light having the first wavelength passing along the first measurement path and exiting the sample container is measured. Clots are detected in response to the measured intensity.

Abstract translation: 提出了一种用于检测液体中凝块的方法。 液体在样品容器中。 通过在可变的垂直照射位置（P-0至P_n）处的第一光源将具有第一波长的光照射到第一光源，使得由第一光源照射的光沿第一测量路径通过样品容器。 测量具有沿着第一测量路径通过并离开样品容器的第一波长的光的强度。 根据测量的强度检测到凝块。

公开(公告)号：US20140118745A1

公开(公告)日：2014-05-01

申请号：US14125093

申请日：2012-06-25

Applicant: Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

Inventor： Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

IPC: G01N21/59

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1′) is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2′) are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2′) are detected by a single image sensor (155).

Abstract translation: 本发明涉及一种用于检查样品的装置，其中第一输入光束（L1）在样品室（111）的检测表面处被全内反射，而第二输入光束（L1'）被透射 样品室（111）。 检测所得到的第一和第二输出光束（L2，L2'），并且可以分别对沮丧的全内反射和光吸收率进行评估。 优选地，两个输出光束（L2，L2'）由单个图像传感器（155）检测。

公开(公告)号：US08687278B2

公开(公告)日：2014-04-01

申请号：US13102107

申请日：2011-05-06

Applicant: Marko Brammer ,  Timo Mappes

Inventor： Marko Brammer ,  Timo Mappes

IPC: G02B27/14 ,  G02B26/10 ,  G02B6/26

CPC classification number: G01N21/51 ,  G01N21/645 ,  G01N2021/015 ,  G01N2021/0187 ,  G01N2021/6463 ,  G01N2201/0636 ,  G01N2201/066

Abstract: An opto-mechanical switch produces different optical paths from two optical path sections out of a plurality of optical path sections that are oriented in different spatial directions. The switch has an optical component on which one end of each optical path section impinges, and which is adapted to be moved linearly in a direction of movement at right angles to the optical path sections between different switching positions, in which it selectively couples different optical path sections optically with each other. Further provided is a measuring system for the analysis of fluids, having such an opto-mechanical switch.

Abstract translation: 光机械开关从沿不同空间方向取向的多个光路部分中的两个光路部分产生不同的光路。 该开关具有光学部件，每个光路部分的一端入射到该光学部件上，该光学部件适于在与不同切换位置之间的光路部分成直角的运动方向上线性移动， 路径部分光学地彼此。 还提供了用于分析具有这种光机械开关的流体的测量系统。

公开(公告)号：US20130314697A1

公开(公告)日：2013-11-28

申请号：US13990692

申请日：2011-11-23

Applicant: Thomas Voit ,  Michael Geissler ,  Harald Quintel ,  Roman Gruler

Inventor： Thomas Voit ,  Michael Geissler ,  Harald Quintel ,  Roman Gruler

IPC: G01N21/03

CPC classification number: G01N21/03 ,  B01L3/50825 ,  B01L2300/043 ,  B01L2300/047 ,  B01L2300/0654 ,  G01N21/0303 ,  G01N2021/0378 ,  G01N2021/6482 ,  G01N2201/066

Abstract: Fluid processing tube for use in optical analysis comprising at least one first portion being made from a first material suitable for optical analysis and being configured to include two optical paths of different lengths, and at least one second portion connected to said first portion and being made from a second material different from said first material.

Abstract translation: 用于光学分析的流体处理管，包括至少一个由适于光学分析的第一材料制成的第一部分，并且被配置为包括两个不同长度的光路，以及至少一个连接到所述第一部分的第二部分，并被制成 从不同于所述第一材料的第二材料。

公开(公告)号：US07796261B2

公开(公告)日：2010-09-14

申请号：US11792097

申请日：2005-12-01

Applicant: Henrik Vilstrup Juhl

Inventor： Henrik Vilstrup Juhl

IPC: G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6）， 优选地，光辐射被设置为以多个波长朝向样品保持器（4）中的样品发射辐射;以及检测装置8，用于在与样品相互作用之后检测辐射。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，可以获得在保留的样品内存在感兴趣物质的指示。

公开(公告)号：US5222389A

公开(公告)日：1993-06-29

申请号：US816596

申请日：1991-12-31

Applicant: Jacob Y. Wong

Inventor： Jacob Y. Wong

IPC: G01N1/00 ,  G01N1/22 ,  G01N21/03 ,  G01N21/05 ,  G01N21/35 ,  G01N21/61 ,  G01N21/85 ,  G01N33/00 ,  G08B17/117 ,  G08B29/20

CPC classification number: G01N1/2258 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/0011 ,  G01N33/0016 ,  G01N33/0031 ,  G08B17/117 ,  G08B29/20 ,  G01N2001/2261 ,  G01N2021/0321 ,  G01N2021/0385 ,  G01N2021/052 ,  G01N2021/158 ,  G01N2021/8585 ,  G01N21/0332 ,  G01N2201/0228 ,  G01N2201/066

Abstract: A gas sample chamber for use in a gas analyzer consists of an elongated hollow tube having an inwardly-facing specularly-reflective surface that permits the tube to function also as a light pipe for conducting radiation from a source to a detector through the sample gas. A number of apertures in the wall of the elongated hollow tube permit the sample gas to enter and exit. Particles of smoke and dust of a size greater than 0.1 micron are kept out of the chamber by use of a semi-permeable membrane that spans the apertures in the hollow tube. Condensation of the sample gas components is prevented by heating the sample chamber electrically to a temperature above the dew point of the component of concern. In one embodiment, at least one detector are spaced around the periphery of the elongated hollow tube adjacent one end of it. In another embodiment, at least one detector are spaced along the length of the elongated hollow tube.

Abstract translation: 用于气体分析仪的气体样品室由具有向内的镜面反射表面的细长的中空管组成，该中空管允许该管还用作通过样品气体从源到检测器的辐射的光管。 细长中空管的壁中的许多孔允许样品气体进出。 通过使用跨越中空管中的孔的半透膜将尺寸大于0.1微米的烟尘颗粒保持在室外。 通过将样品室电加热到高于所关注部件的露点的温度来防止样品气体组分的冷凝。 在一个实施例中，至少一个检测器围绕其一端的细长中空管的周边间隔开。 在另一个实施例中，至少一个检测器沿着细长的中空管的长度间隔开。