公开(公告)号：US20220387992A1

公开(公告)日：2022-12-08

申请号：US17771068

申请日：2020-10-23

Applicant: RADISENS DIAGNOSTICS LTD.

Inventor： Fabio Miguel Rolo Pereria ,  Donal Cronin ,  David Doolan ,  Yan Zhao ,  Eoin O'Nuallain

IPC: B01L3/00

Abstract: The invention provides a microfluidic system comprising a cartridge coupled to a motor and adapted to move a fluid sample to a plurality of locations on the cartridge.

公开(公告)号：US20210229090A1

公开(公告)日：2021-07-29

申请号：US17050635

申请日：2019-04-29

Applicant: RADISENS DIAGNOSTICS LTD.

Inventor： David Doolan ,  Donal Cronin ,  Eoin O'Nuallain ,  Fabio Miguel Rolo Pereira ,  Yan Zhao

IPC: B01L3/00

Abstract: The invention provides a microfluidic system comprising a cartridge coupled to a motor and adapted to move a fluid sample to a plurality of locations on the cartridge. The cartridge is configured to rotate on an inclined plane, thus providing for a combination of centrifugal force and gravitational force to move the fluid sample within the cartridge. Such a configuration may facilitate the performance of a sequential assay by making it easier to move a fluid radially inwards within the cartridge. The cartridge provided comprises a reaction chamber (15) with at least three zones within the chamber: a first zone (Zone A) is positioned radially outward comprises a cuvette (45) for optical measurement; a second and third zones (Zones B and C) are positioned closer to a centre of rotation (25) and may comprise dried reagents spots (R1, R2).

公开(公告)号：US20140374622A1

公开(公告)日：2014-12-25

申请号：US14367353

申请日：2012-12-21

Applicant: RADISENS DIAGNOSTICS LTD.

Inventor： Donal Cronin ,  Jerry O'Brien ,  Lee Barry

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01J1/0418 ,  G01J1/0492 ,  G01J1/18 ,  G01J3/36 ,  G01J2003/1213 ,  G01N15/14 ,  G01N15/1484 ,  G01N21/645 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/066 ,  G01N2201/12

Abstract: The invention provides a high resolution, wide dynamic range, multi-colour detection platform for microfluidic analysers/instruments and methods. The detection platform uses multiple high gain semiconductor optical sensors for the detection of luminescence from cellular or biological samples. The digitized outputs from these sensors are combined and weighted in a signal processing unit, using pre-determined algorithms for each colour, which optimise the resolution in each of these high gain semiconductor optical sensors while extending the dynamic range of the detection platform.

Abstract translation: 本发明提供了用于微流控分析仪/仪器和方法的高分辨率，宽动态范围的多色检测平台。 检测平台使用多个高增益半导体光学传感器来检测来自细胞或生物样品的发光。 来自这些传感器的数字化输出在信号处理单元中被组合和加权，使用用于每种颜色的预定算法，其优化每个这些高增益半导体光学传感器中的分辨率，同时延长检测平台的动态范围。

公开(公告)号：US09518925B2

公开(公告)日：2016-12-13

申请号：US14367353

申请日：2012-12-21

Applicant: RADISENS DIAGNOSTICS LTD.

Inventor： Donal Cronin ,  Jerry O'Brien ,  Lee Barry

IPC: G01N21/64 ,  G01J1/04 ,  G01J1/18 ,  G01J3/36 ,  G01N21/76 ,  G01J3/12 ,  G01N15/14

CPC classification number: G01N21/6486 ,  G01J1/0418 ,  G01J1/0492 ,  G01J1/18 ,  G01J3/36 ,  G01J2003/1213 ,  G01N15/14 ,  G01N15/1484 ,  G01N21/645 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/066 ,  G01N2201/12

Abstract: The invention provides a high resolution, wide dynamic range, multi-color detection platform for microfluidic analyzers/instruments and methods. The detection platform uses multiple high gain semiconductor optical sensors for the detection of luminescence from cellular or biological samples. The digitized outputs from these sensors are combined and weighted in a signal processing unit, using pre-determined algorithms for each color, which optimize the resolution in each of these high gain semiconductor optical sensors while extending the dynamic range of the detection platform.

Abstract translation: 本发明提供了用于微流控分析仪/仪器和方法的高分辨率，宽动态范围的多色检测平台。 检测平台使用多个高增益半导体光学传感器来检测来自细胞或生物样品的发光。 来自这些传感器的数字化输出在信号处理单元中被组合和加权，使用用于每种颜色的预定算法，其优化每个这些高增益半导体光学传感器中的分辨率，同时延长检测平台的动态范围。