公开(公告)号：US20240002780A1

公开(公告)日：2024-01-04

申请号：US18252558

申请日：2021-11-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yadong Yin ,  Dilong Liu

IPC: C12N1/20 ,  C01B33/14 ,  C01G49/08 ,  C01G7/00 ,  C01B19/00 ,  C01G49/06 ,  C01G49/02 ,  B22F9/24 ,  B22F1/054 ,  C08G73/02 ,  C07K14/47 ,  C07H21/04 ,  B01J13/08

CPC classification number: C12N1/20 ,  C01B33/14 ,  C01G49/08 ,  C01G7/00 ,  C01B19/007 ,  C01G49/06 ,  C01G49/02 ,  B22F9/24 ,  B22F1/054 ,  C08G73/0273 ,  C07K14/4732 ,  C07H21/04 ,  B01J13/08 ,  C01P2002/10 ,  C01P2002/20 ,  C01P2004/03 ,  B22F2301/255

Abstract: A method is disclosed of assembling building blocks into supraparticles. The method includes applying a first solvent on a template of patterned recessed regions to wet surfaces of the recessed regions; applying a second solvent on the template of patterned recessed regions, the building blocks suspended in the second solvent; wherein the first solvent and the second solvent are partially miscible, resulting in negligible interfacial surface tension between the first and second solvents; and wherein droplets of the second solvent diffuse droplets of the first solvent in the recessed regions, thereby assembling the building blocks into the supraparticles in the recessed regions.

公开(公告)号：US11850852B2

公开(公告)日：2023-12-26

申请号：US17550484

申请日：2021-12-14

Applicant: IamFluidics Holding B.V.

Inventor： Claas Willem Visser ,  Tom Kamperman ,  Hermanus Bernardus Johannes Karperien ,  Detlef Lohse

IPC: B41J2/21 ,  B41J2/14 ,  B01J13/08 ,  B01J13/14

CPC classification number: B41J2/14 ,  B01J13/08 ,  B01J13/14 ,  B41J2/211

Abstract: A production process comprises a formation process that includes: contacting a first liquid material and a second liquid material with each other at a contact point in a gas atmosphere, wherein at the contact point at least one of the first liquid material and the second liquid material is provided as a liquid jet propagating in a direction, to provide at the contact point a third jet of a coalesced third material propagating in a third direction. A production process device can perform the formation process.

公开(公告)号：US11786881B2

公开(公告)日：2023-10-17

申请号：US16605991

申请日：2018-04-18

Applicant: NANOMI, B.V.

Inventor： Lucie Anne Aude Leduc ,  Robertus Franciscus Duwel ,  Miriam Girones Nogue ,  Gerrit Jan Veldhuis

IPC: A61K9/16 ,  B01F23/00 ,  B01F23/41 ,  B01J13/08 ,  B01D11/04 ,  B01D39/10 ,  B01F25/314 ,  B01F33/302 ,  B01F101/22

CPC classification number: B01J13/08 ,  A61K9/1682 ,  B01D11/0492 ,  B01D39/10 ,  B01F23/4105 ,  B01F25/3142 ,  B01F33/302 ,  B01F2101/22

Abstract: Provided herein is a first fluid dispersed in a second fluid to form an emulsion of micro-droplets having an average droplet size and having a droplet size distribution around the average droplet size and below a maximum droplet size. The micro-droplets will lose their solvent to transform to micro-spheres exhibiting a particle size distribution around an average particle size and substantially below a maximum allowable particle size. The micro-spheres are subjected to a micro-filter having a relatively narrow pore size distribution around an average pore size, which average pore size is between the average particle size and the maximum particle size. A filtrate of the micro-filter comprises a majority of the micro-spheres that is substantially void of micro-spheres having a particle size exceeding the maximum allowable particle size.

公开(公告)号：US20230183059A1

公开(公告)日：2023-06-15

申请号：US18167104

申请日：2023-02-10

Applicant: FUJIFILM CORPORATION

Inventor： Ryo MATSUNO

IPC: B81C1/00 ,  C08L29/04 ,  C08L83/04 ,  B01J13/08 ,  B81B1/00 ,  B01F33/302 ,  B01F23/41 ,  B01F23/23

CPC classification number: B81C1/00119 ,  C08L29/04 ,  C08L83/04 ,  B01J13/08 ,  B81B1/00 ,  B01F33/3021 ,  B01F23/41 ,  B01F23/23 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00831 ,  B01J2219/00822 ,  B01J2219/00804 ,  C08L2201/52 ,  C08L2207/324 ,  B81C2201/019

Abstract: The present disclosure provides a microchannel device including a first base having a defining surface that defines a flow channel and containing a polymer that contains a fluorine atom and a second base having a defining surface that defines the flow channel together with the defining surface of the first base, having solvent resistance, and coming into contact with the first base, in which an arithmetic average roughness Ra of a surface of the first base, exposed by peeling the second base from the first base, is 1 μm or more, and provides a use application thereof.

公开(公告)号：US11674955B2

公开(公告)日：2023-06-13

申请号：US17724894

申请日：2022-04-20

Applicant: The University of Massachusetts

Inventor： Matthew A. Holden ,  Max J. Lein ,  Arash Manafirad ,  Dan Ezra Aurian-Blajeni

IPC: G01N33/543 ,  G01N33/68 ,  B01J13/08

CPC classification number: G01N33/5432 ,  B01J13/08 ,  G01N33/6872 ,  G01N2500/20

Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.

公开(公告)号：US20230138940A1

公开(公告)日：2023-05-04

申请号：US18090557

申请日：2022-12-29

Applicant: AGC Inc. ,  AGC Si-Tech Co., Ltd.

Inventor： Hiroyuki KAMIYA ,  Hyunji KIM ,  Toshiya MATSUBARA

IPC: C01B33/193 ,  B01J13/08

Abstract: To provide hollow silica particles having a dense silica shell layer.
A method for producing hollow silica particles, which comprises: adjusting the pH of an oil-in-water emulsion containing an aqueous phase, an oil phase and a surfactant to at most 3.0 and adding a first silica material to the oil-in-water emulsion, adding a second silica material to the emulsion having the first silica material added, at its pH of at least 8, in the presence of alkali metal ions, to obtain a hollow silica precursor dispersion, and obtaining a hollow silica precursor from the hollow silica precursor dispersion and obtaining hollow silica particles from the hollow silica precursor.

公开(公告)号：US11602721B2

公开(公告)日：2023-03-14

申请号：US16735251

申请日：2020-01-06

Applicant: THE SECANT GROUP, LLC

Inventor： Steven Lu ,  Peter D. Gabriele ,  Julia Donnelly ,  Brian Ginn ,  Charles Brendan Nicholson ,  Jeremy J. Harris ,  Michael S. Flemmens

IPC: B01J13/08 ,  A61L27/56 ,  A61L27/54 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L15/22 ,  C09J133/06 ,  C09J123/20 ,  A61L27/58 ,  C08J9/24 ,  A61L31/04 ,  A61L27/14 ,  A61L24/00 ,  A61L24/04

Abstract: A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.

公开(公告)号：US11439708B2

公开(公告)日：2022-09-13

申请号：US15503983

申请日：2015-10-05

Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC ,  The Regents of the University of California ,  UNIVERSIDAD DEL PAÍS VASCO

Inventor： Aleksandr Noy ,  Jia Geng ,  Jianfei Zhang ,  Vadim Frolov

IPC: A61K47/02 ,  C01G39/06 ,  C01B21/064 ,  C01B32/174 ,  C01B32/176 ,  C01B32/17 ,  C01B32/172 ,  A01N25/04 ,  A61K9/00 ,  A61K9/127 ,  B01J13/08 ,  B01J13/20 ,  G01N27/447 ,  B82Y15/00 ,  B82Y5/00 ,  B82Y40/00 ,  C12Q1/6825 ,  C12Q1/6869

Abstract: Provided herein is a nanopore structure, which in one aspect is a “carbon nanotube porin”, that comprises a short nanotube with an associated lipid coating. Also disclosed are compositions and methods enabling the preparation of such nanotube/lipid complexes. Further disclosed is a method for therapeutics delivery that involves a drug delivery agent comprising a liposome with a NT loaded with a therapeutic agent, introducing the therapeutic agent into a cell or a tissue or an organism; and subsequent release of the therapeutic agents into a cell.

公开(公告)号：US20220211637A1

公开(公告)日：2022-07-07

申请号：US17609887

申请日：2020-05-06

Applicant: The Trustees of Princeton University

Inventor： Robert F. Pagels ,  Chester E. Markwalter ,  Justin Gourary ,  Robert K. Prud'homme

IPC: A61K9/51 ,  B01J13/08 ,  A61K31/711 ,  A61K31/7105 ,  A61K38/47 ,  A61K31/7036 ,  A61K38/14 ,  A61K9/16 ,  A61K38/12

Abstract: Disclosed is a process to make nanoparticles highly loaded with water soluble actives, including biologics such as proteins and peptides, which are stabilized by random copolymers. The random copolymers used have all been approved by the FDA for oral formulations. The nanoparticles have a hydrophilic core and a hydrophobic corona and can be further processed through a number of different routes. The process to make these particles is highly scalable and could be used industrially.

公开(公告)号：US11331640B2

公开(公告)日：2022-05-17

申请号：US16781004

申请日：2020-02-04

Applicant: Shin-Etsu Chemical Co., Ltd.

Inventor： Hiroaki Saito ,  Toshihiko Kawakubo

IPC: C08L1/28 ,  B01J13/08 ,  C08L27/06

Abstract: A microcapsule includes a core/shell structure, in which the shell includes a water-soluble polymer and the core includes an organic peroxide. The water-soluble polymer is preferably at least one water-soluble polymer selected from the group consisting of polyvinyl alcohol, gelatin, poly(meth)acrylic acid derivatives, polyvinyl pyrrolidone, and polyethylene oxide. The polyvinyl alcohol is preferably partially saponified polyvinyl alcohol having a degree of saponification of 80% by mole or more and 99.5% by mole or less and an average degree of polymerization of 1,500 or more and 3,500 or less.