公开(公告)号：US20210405064A1

公开(公告)日：2021-12-30

申请号：US17476971

申请日：2021-09-16

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development

Inventor： Ying Mei ,  Jia Jia ,  Chung-Jen James Chou

IPC: G01N33/68 ,  C07K7/06 ,  C07K7/08 ,  A61P9/10 ,  G01N33/74 ,  C07K14/78 ,  C07K17/02 ,  C07K14/71 ,  C07K14/755 ,  C07K14/52 ,  C07K14/75 ,  C07K14/705

Abstract: The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.

公开(公告)号：US10994468B2

公开(公告)日：2021-05-04

申请号：US16381653

申请日：2019-04-11

Applicant: CLEMSON UNIVERSITY

Inventor： Joseph Choma

IPC: B29C53/06 ,  B29C59/00 ,  B29C70/30 ,  B05D1/32 ,  E04C3/34 ,  B32B27/08 ,  B32B27/20 ,  B32B7/08 ,  B29L7/00 ,  B32B27/38 ,  B29L31/10 ,  E04C3/28 ,  E04C3/29

Abstract: Foldable composite structures and methods for fabricating foldable composite structures are provided. For example, a method comprises selectively applying a rigidifying substance to a sheet of composite material to define a plurality of hinges; allowing the rigidifying substance to cure; and folding the sheet of composite material along the hinges to form the composite structure. As another example, a method comprises laying out flat a sheet of composite material; masking a plurality of hinges on the sheet; applying a polymer to a sheet face; curing the polymer; removing the masking; and folding the sheet along the hinges to form the composite structure. An exemplary foldable composite structure comprises a planar sheet of composite material folded to define a plurality of surface segments and a plurality of hinges. A portion of the hinges form peaks and the remainder of the hinges form valleys. The hinges are defined between adjacent surface segments.

公开(公告)号：US10883962B2

公开(公告)日：2021-01-05

申请号：US15875398

申请日：2018-01-19

Applicant: University of Kentucky Research Foundation ,  Clemson University Research Foundation

Inventor： Guigen Zhang ,  Samuel Bearden

IPC: G01N27/447 ,  G01N33/487 ,  C12Q1/6869

Abstract: Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.

公开(公告)号：US10441550B2

公开(公告)日：2019-10-15

申请号：US15046675

申请日：2016-02-18

Applicant: BioSurfaces, Inc. ,  Clemson University ,  Rhode Island Board of Education

Inventor： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

IPC: A61K9/70 ,  A61K31/4196 ,  A61K31/337 ,  A61K31/496 ,  A61K9/00 ,  D04H1/435 ,  D04H1/728 ,  D04H3/011 ,  D04H3/02 ,  D04H3/16 ,  D01D1/02 ,  D01D5/00 ,  D01F6/62 ,  B29C48/05 ,  A61F2/82 ,  B29C48/00

Abstract: The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.

公开(公告)号：US20190240594A1

公开(公告)日：2019-08-08

申请号：US16267579

申请日：2019-02-05

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： R. KENNETH MARCUS ,  TERRI F. BRUCE ,  LEI WANG ,  SISI HUANG ,  TYLER Y. SLONECKI ,  RHONDA REIGERS POWELL

IPC: B01D15/32 ,  G01N33/50 ,  G01N1/40

CPC classification number: B01D15/327 ,  A61K35/68 ,  B01J20/262 ,  B01J20/28023 ,  B01J20/285 ,  B01J20/286 ,  B01J2220/54 ,  C07K14/47 ,  G01N1/405 ,  G01N33/5005

Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)

公开(公告)号：US20190119110A1

公开(公告)日：2019-04-25

申请号：US16158366

申请日：2018-10-12

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  CLEMSON UNIVERSITY

Inventor： Fanglin Chen ,  Shumin Fang ,  Kyle Brinkman ,  Siwei Wang ,  Jian He ,  Yufei Liu

IPC: C01B3/50 ,  C04B35/50 ,  B01D71/02 ,  B01D67/00 ,  B01D53/22 ,  B01D53/32

Abstract: A hydrogen permeation membrane is provided that can include a carbon-based material (C) and a ceramic material (BZCYT) mixed together. The carbon-based material can include graphene, graphite, carbon nanotubes, or a combination thereof. The ceramic material can have the formula BaZr1-x-y-zCexYyTzO3-δ, where 0≤x≤0.5, 0≤y≤0.5, 0≤z≤0.5, (x+y+z)>0; 0≤δ≤0.5, and T is Yb, Sc, Ti, Nb, Ta, Mo, Mn, Fe, Co, Ni, Cu, Zn, Ga, In, or a combination thereof. In addition, the BZYCT can be present in the C-BZCYT mixture in an amount ranging from about 40% by volume to about 80% by volume. Further, a method of forming such a membrane is also provided. A method is also provided for extracting hydrogen from a feed stream.

公开(公告)号：US20190112191A1

公开(公告)日：2019-04-18

申请号：US16157167

申请日：2018-10-11

Applicant: CLEMSON UNIVERSITY

Inventor： Rodrigo Martinez-Duarte ,  Monsur Islam ,  Joshua Flach

IPC: C01B32/05

CPC classification number: C01B32/05 ,  C01B32/90

Abstract: Methods for forming carbon-based cellular structures and 3D structures that can be formed by use of the methods are described. Methods include shaping an essentially 2D sheet that includes an organic polymer to form a 3D precursor followed by heat treatment of the 3D precursor. Heat treatment carbonizes the polymer to form an amorphous carbon. A metal precursor solution can be applied to the 3D precursor, and subsequent heat treatment can form a metal carbide, metal nanoparticles, or other carbon-based materials on/in the cellular structures.

公开(公告)号：US10244818B2

公开(公告)日：2019-04-02

申请号：US15046661

申请日：2016-02-18

Applicant: CLEMSON UNIVERSITY

Inventor： John DesJardins ,  Scott Edward Stanley ,  Breanne Przestrzelski ,  Timothy C. Pruett ,  Steve L. Hoeffner ,  Brian Daryl Kaluf

IPC: A43B13/20 ,  A43B7/28 ,  A43B17/00 ,  A43B17/02 ,  A61F5/01 ,  A43B17/03 ,  A43B1/00 ,  B33Y10/00

Abstract: Orthotics and methods for forming orthotics are described. The orthotics can be designed with a patient-specific design and can include variation in hardness across the orthotic so as to satisfy clinical need. An orthotic can be a custom-designed orthotic formed according to an additive manufacturing process such as a 3-D printing methodology. Through utilization of on-site formation methods such as 3-D printing, an orthotic can be designed, formed and fit at the point of care in a much shorter time period than traditional orthotics. The orthotics can include a layer that includes a plurality of cells across the layer. The layer can exhibit variable hardness across the layer through variation in cell void volume and optionally material of formation across the layer.

公开(公告)号：US10232050B1

公开(公告)日：2019-03-19

申请号：US14966614

申请日：2015-12-11

Applicant: Clemson University

Inventor： Jeoung Soo Lee

IPC: A61K48/00 ,  A61K31/337 ,  A61K47/48 ,  A61K31/713 ,  A61K31/4015 ,  C07K16/28

Abstract: Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.

公开(公告)号：US10188025B2

公开(公告)日：2019-01-29

申请号：US15209909

申请日：2016-07-14

Applicant: CLEMSON UNIVERSITY

Inventor： Kendall R. Kirk ,  H. Guy Ramsey, IV

IPC: A01B79/00 ,  A01F15/07 ,  A01F15/08 ,  G01G17/02 ,  A01D89/00 ,  G01B17/00 ,  G01B11/00

Abstract: Disclosed are methods and systems for determining the amount of material contained in a windrow. In particular embodiments, the methods and systems are applicable to agricultural applications, and in particular to hay yield monitoring. Systems include a remote sensing technology to determine windrow height. Remote sensing methods can include ultrasonic sensors, optical sensors, and the like. Systems can provide real time yield data.