公开(公告)号：US20240293799A1

公开(公告)日：2024-09-05

申请号：US18644518

申请日：2024-04-24

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/28 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07F7/18

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  C07F7/1804 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/32 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/80

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20240157334A1

公开(公告)日：2024-05-16

申请号：US18281095

申请日：2022-06-03

Applicant: Resonac Corporation

Inventor： Naoki UCHIYAMA ,  Yuzuru KOKIDO

IPC: B01J20/285 ,  B01D15/34 ,  B01J20/26 ,  B01J20/30

CPC classification number: B01J20/285 ,  B01D15/34 ,  B01J20/264 ,  B01J20/3085

Abstract: Provided are a packing material used for size exclusion chromatography, which has high alkali resistance and suppressed non-specific adsorption, and a method for producing the same. A packing material, wherein one end of a block copolymer represented by the following formula 1 is bonded to a porous organic polymer carrier containing 60 to 95 mol % of a repeating unit derived from glycidyl methacrylate and 5 to 40 mol % of a repeating unit derived from a polyfunctional monomer via an ether bond derived from a terminal hydroxyl group,


HO—(C2H4O)l—(C3H6O)m—(C2H4O)n—H  (formula 1)

wherein l is an integer of 5 to 140, m is an integer of 15 to 75, and n is an integer of 5 to 140, and a proportion of m to a sum of l, m, and n is 5 to 85%.

公开(公告)号：US11977011B2

公开(公告)日：2024-05-07

申请号：US17832113

申请日：2022-06-03

Applicant: Dylan Elmer Wilks

Inventor： Dylan Elmer Wilks

IPC: G01N1/40 ,  B01D15/32 ,  B01J20/20 ,  B01J20/283 ,  B01J20/285 ,  B01J20/292 ,  G01N1/44 ,  G01N30/02 ,  G01N30/14

CPC classification number: G01N1/4055 ,  B01D15/325 ,  G01N1/44 ,  G01N30/14 ,  B01J20/205 ,  B01J20/283 ,  B01J20/285 ,  B01J20/292 ,  G01N2001/4038 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N2030/027 ,  G01N2030/143

Abstract: In accordance with embodiments of the present invention, a terpene-rich sample is prepared for terpene analysis using liquid chromatography via an extraction method that takes little time, uses minimal external equipment, and permits direct injection of extracted terpenes into a liquid chromatography instrument for analysis. An embodiment of the invention involves preparing a terpene-containing sample for analysis by liquid chromatography by liquid extraction; heating the liquid extract in a vial that contains a filter medium or solvent; collecting the terpenes in the medium by the vapor pressure forced through the filter from heating; and eluting the collected terpenes into a vial or directly into a chromatography injector.

公开(公告)号：US20240066500A1

公开(公告)日：2024-02-29

申请号：US18265831

申请日：2021-11-25

Applicant: Bundesrepblik Deutschland, vertreten durch den Bundesminister für Wirtschaft und Energie, dieser ver

Inventor： Martha Wamaitha Kimani ,  Kornelia Gawlitza ,  Knut Rurack ,  Virginia Valderrey Berciano ,  Victor Pérez Padilla

IPC: B01J20/26 ,  B01D15/38 ,  B01J20/10 ,  B01J20/28 ,  B01J20/285 ,  C09K11/06 ,  G01N21/64

CPC classification number: B01J20/268 ,  B01D15/3852 ,  B01J20/103 ,  B01J20/28007 ,  B01J20/28011 ,  B01J20/28016 ,  B01J20/285 ,  C09K11/06 ,  G01N21/6428 ,  C09K2211/1466 ,  C09K2211/1475

Abstract: A layer structure having a solid substrate having a surface, the surface carrying a layer including a molecularly imprinted polymer, wherein the molecularly imprinted polymer is adapted to bind a glyphosate analyte, wherein the glyphosate analyte is selected from glyphosate, a glyphosate degradation product, a metabolite of glyphosate or a metabolite of the degradation product of glyphosate, wherein a fluorescence characteristic of the molecularly imprinted polymer changes upon binding of the glyphosate analyte. Further, a method for detecting a glyphosate analyte in a sample includes: providing the layer structure having the molecularly imprinted polymer; providing a fluidic contact of the layer structure with the sample or an organic extract of the sample; measuring a fluorescence property of the layer structure; and estimating a concentration of glyphosate or of the glyphosate related analyte at least semi-quantitatively.

公开(公告)号：US20240018184A1

公开(公告)日：2024-01-18

申请号：US18354413

申请日：2023-07-18

Applicant: CYTIVA BIOPROCESS R&D AB

Inventor： Annika Forss ,  Gustav José Rodrigo ,  Tomas Bjorkman ,  Mats Ander ,  Jesper Ulf Hansson

IPC: C07K1/22 ,  B01J20/26 ,  B01J20/285 ,  B01J20/286 ,  B01J20/32 ,  C07K14/31 ,  C07K16/00 ,  C07K16/12 ,  C07K17/10

CPC classification number: C07K1/22 ,  B01J20/267 ,  B01J20/285 ,  B01J20/286 ,  B01J2220/52 ,  C07K14/31 ,  C07K16/00 ,  C07K16/1271 ,  C07K17/10 ,  B01J20/3274

Abstract: The present invention concerns a method of cleaning and/or sanitizing a separation matrix comprising multimers of immunoglobulin-binding alkali-stabilized Protein A domains covalently coupled to a porous support. The method comprises the steps of:

a) optionally purifying a mixture comprising a first immunoglobulin using the separation matrix;
b) providing a cleaning liquid comprising at least 50% by volume of an aqueous alkali metal hydroxide solution; and
c) cleaning and/or sanitizing the separation matrix by contacting the cleaning liquid with the separation matrix for a predetermined contact time.


The alkali-stabilized Protein A domains comprise mutants of a parental Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO 51 or SEQ ID NO 52, wherein the amino acid residues at positions 13 and 44 of SEQ ID NO 51 or 52 are asparagines and wherein at least the asparagine residue at position 3 of SEQ ID NO 51 or 52 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.

公开(公告)号：US20240001338A1

公开(公告)日：2024-01-04

申请号：US18360870

申请日：2023-07-28

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： CHRISTOPHER BELISLE ,  JIALI LIAO ,  EDWIN LOZANO

IPC: B01J20/285 ,  B01J20/289 ,  B01J20/30 ,  C07K1/16 ,  B01D15/38 ,  B01J20/28

CPC classification number: B01J20/285 ,  B01J20/289 ,  B01J20/3042 ,  C07K1/165 ,  B01D15/3847 ,  B01D15/3809 ,  B01J20/28085 ,  B01J2220/52

Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.

公开(公告)号：US11685793B2

公开(公告)日：2023-06-27

申请号：US14913374

申请日：2014-08-13

Applicant: JNC CORPORATION

Inventor： Toru Kurabayashi ,  Shigeyuki Aoyama ,  Akihiro Uchida

IPC: C08B3/06 ,  C08J3/14 ,  B01J39/22 ,  B01J39/05 ,  B01J39/26 ,  C08L1/12 ,  B01J20/285 ,  B01J20/24 ,  B01J20/30

CPC classification number: C08B3/06 ,  B01J20/24 ,  B01J20/285 ,  B01J20/3085 ,  B01J39/05 ,  B01J39/22 ,  B01J39/26 ,  C08J3/14 ,  C08L1/12 ,  C08J2301/12

Abstract: One embodiment shows a method for producing porous cellulose particles, including:



(a) dissolving cellulose diacetate into a solvent to prepare a cellulose diacetate solution;
(b) dispersing the cellulose diacetate solution into a medium immiscible with the cellulose diacetate solution to obtain a dispersed system;
(c) cooling the dispersed system;
(d) adding a poor solvent to the cooled dispersed system to precipitate cellulose diacetate particles; and
(e) saponifying the cellulose diacetate particles.

公开(公告)号：US20190210003A1

公开(公告)日：2019-07-11

申请号：US15520390

申请日：2015-10-01

Applicant: JNC CORPORATION

Inventor： Natuki OKANIWA ,  Tsuyoshi NAKAMA ,  Eri IWAMOTO ,  Shuji SASAKI ,  Takuo IKEDA

IPC: B01J20/24 ,  B01J20/28 ,  B01J20/285 ,  B01J20/30 ,  B01D15/36 ,  B01J41/16 ,  B01J41/07 ,  C08B15/00 ,  C08B15/06 ,  C08J9/28 ,  B01J20/281

CPC classification number: B01J20/24 ,  B01D15/361 ,  B01J20/28042 ,  B01J20/281 ,  B01J20/285 ,  B01J20/30 ,  B01J20/305 ,  B01J20/3085 ,  B01J41/05 ,  B01J41/07 ,  B01J41/16 ,  B01J2220/52 ,  C07K1/16 ,  C07K1/18 ,  C08B15/005 ,  C08B15/06 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/026 ,  C08J2301/12 ,  G01N30/482 ,  G01N30/88 ,  G01N2030/484

Abstract: Provided is a manufacturing method for monolithic structure that is a porous body formed of polysaccharide being a naturally-occurring polymer, has continuous pores with an average pore diameter suitable for biomolecule separation, and allows formation into arbitrary shape. The polysaccharide monolithic structure is manufactured by a method including a first step of obtaining a polysaccharide solution by dissolving polysaccharide into a mixed solvent of a first component and a second component at temperature lower than a boiling point of the mixed solvent, and a second step of obtaining polysaccharide monolithic structure by cooling the polysaccharide solution, wherein the first component is a solvent selected from lactate, and the second component is a solvent selected from water, lower alcohol, and a combination thereof. The monolithic structure obtained is a porous body having continuous pores with an average pore diameter of 0.01 to 20.0 micrometers, and a thickness of 100 micrometers or more.

公开(公告)号：US20190193050A1

公开(公告)日：2019-06-27

申请号：US16301303

申请日：2017-07-10

Applicant: HITACHI CHEMICAL COMPANY, LTD.

Inventor： Masashi MARUYAMA ,  Nanae YAMASHITA ,  Yuzuru SHIMAZAKI ,  Hiroshi YOSHIDA ,  Keisuke SHIBUYA

IPC: B01J20/26 ,  B01D15/38 ,  B01J20/285 ,  B01D15/02 ,  C12N9/76 ,  C07K16/00 ,  C07K14/76 ,  C07K1/22

CPC classification number: B01J20/26 ,  B01D15/00 ,  B01D15/02 ,  B01D15/08 ,  B01D15/3809 ,  B01D15/3814 ,  B01D15/3823 ,  B01J20/28 ,  B01J20/285 ,  C07K1/22 ,  C07K14/76 ,  C07K16/00 ,  C12M1/26 ,  C12N9/6427 ,  G01N30/88

Abstract: An object of the present invention is to provide an adsorbent material having high dispersibility and reversibility. The adsorbent material has a polymer material having a plurality of functional groups ionizable in water and exhibiting no lower limit critical solution temperature, an adsorption site capable of interacting with a target substance, and a carrier.

公开(公告)号：US20180230284A1

公开(公告)日：2018-08-16

申请号：US15751743

申请日：2016-08-05

Applicant: KYOTO UNIVERSITY ,  EMAUS KYOTO, INC. ,  KOSEN NATIONAL INSTITUTE OF TECHNOLOGY

Inventor： Norio ISHIZUKA ,  Kyoko KONISHI ,  Toshikazu ODA ,  Yoshinobu TSUJII ,  Keita SAKAKIBARA ,  Takaya SATO

IPC: C08J9/28 ,  C08G59/32 ,  C08G59/50 ,  C08F22/10 ,  C08F293/00

CPC classification number: C08J9/286 ,  A61K8/81 ,  A61K8/84 ,  B01J20/264 ,  B01J20/28016 ,  B01J20/285 ,  B01J20/3064 ,  C08F22/105 ,  C08F293/00 ,  C08F293/005 ,  C08G59/3218 ,  C08G59/3245 ,  C08G59/5026 ,  C08J9/0061 ,  C08J2201/0543 ,  C08J2205/05 ,  C08J2335/02 ,  C08J2363/00 ,  C08J2453/00

Abstract: The present invention provides porous particles made of an organic polymer, uniform in shape, and having through holes that are not closed. The porous particles according to the present invention are porous particles having a substantially spherical shape. The porous particles are made of an organic polymer. Each of the porous particles has an interconnected pore structure in which through holes provided inside the porous particle communicate with each other, and ends of the through holes are open toward an outside of the porous particle.