公开(公告)号：US20190175699A1

公开(公告)日：2019-06-13

申请号：US16282199

申请日：2019-02-21

Applicant: Regeneron Pharmaceuticals, Inc. ,  University Health Network

Inventor： Lisa Arleen Purcell Ngambo ,  Sarah J. Higgins ,  Kevin C. Kain

IPC: A61K38/18 ,  A61K31/49 ,  A61K31/365 ,  A61K38/16 ,  A61K38/17 ,  C07K14/515 ,  A61K31/357 ,  A61K45/06 ,  C07K16/22 ,  A61K39/395

Abstract: The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as AngF1-Fc-F1.

公开(公告)号：US10314548B2

公开(公告)日：2019-06-11

申请号：US15514323

申请日：2015-09-24

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Marshall Stephen Sussman ,  Bernd Juergen Wintersperger ,  Kai-Ho Fok ,  Issac Yiqun Yang

IPC: G01R33/50 ,  G01R33/54 ,  A61B5/00 ,  A61B5/055 ,  G01R33/561

Abstract: Methods and systems for performing T1 mapping. T1 samples are obtained from an acquisition including one or more inversion groupings. The acquisition may be designed to result in incomplete tissue magnetization recovery between inversion groupings. The acquisition may be designed for the use of non-uniform, non-180° preparatory pulses. The method may also include the combined use of data from different inversion groupings. A model is used in which fit parameters are variable dependent on the inversion grouping.

公开(公告)号：US20190144848A1

公开(公告)日：2019-05-16

申请号：US16098620

申请日：2017-05-03

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Daniel Diniz DE CARVALHO ,  Shu Yi SHEN ,  Rajat SINGHANIA

IPC: C12N15/10

Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.

公开(公告)号：US10278639B2

公开(公告)日：2019-05-07

申请号：US14694198

申请日：2015-04-23

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Hisham Alshaer ,  T. Douglas Bradley

IPC: A61B5/08 ,  A61B5/00 ,  A61B7/00

Abstract: Described herein are various embodiments of a method and system for sleep detection. For example, in one embodiment, a method is described for automatically characterizing digitized breath sounds recorded from a subject over time as indicative of the subject being one of asleep and awake. This method comprises identify individual breathing cycles in a given segment of the recorded breath sounds; calculating one or more preset breathing cycle characteristics from the identified breathing cycles; evaluating a relative regularity of the calculated characteristics for the given segment; and upon the relative regularity satisfying a preset high regularity condition, outputting a sleep status indicator that the subject was likely asleep during the segment, otherwise outputting a wake indicator that the subject was likely awake during the segment.

公开(公告)号：US20190093174A1

公开(公告)日：2019-03-28

申请号：US16118038

申请日：2018-08-30

Applicant: THE HOSPITAL FOR SICK CHILDREN ,  UNIVERSITY HEALTH NETWORK

Inventor： Jean C.Y. Wang ,  John Dick ,  Jayne Danska ,  Liqing Jin ,  Alexandre Theocharides ,  Sujeetha Rajakumar

IPC: C12Q1/6886 ,  A61K38/16

Abstract: The invention relates to modulating the SIRPα-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRPα polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.

公开(公告)号：US10137205B2

公开(公告)日：2018-11-27

申请号：US15211586

申请日：2016-07-15

Applicant: University Health Network

Inventor： Jeffrey A. Medin ,  Sean Devine

IPC: C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C07H21/04 ,  A61K48/00 ,  C07K14/705 ,  C12N9/12 ,  C12N5/16 ,  C12N15/864 ,  C12N15/861 ,  C12N15/867 ,  A61K38/00

Abstract: The application relates to a composition comprising a stably integrating delivery vector, a modified mammalian thymidylate kinase (tmpk) that increases phosphorylation of a prodrug relative to phosphorylation of the prodrug by wild-type human tmpk, and a detection cassette fused to the tmpk. The application also relates to use of these compositions in methods of treatment of diseases, such as graft versus host disease and cancer.

公开(公告)号：US20180325377A1

公开(公告)日：2018-11-15

申请号：US16027775

申请日：2018-07-05

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DACOSTA ,  Brian C. WILSON ,  Kai ZHANG

IPC: A61B5/00 ,  A61B5/01 ,  G01N21/64 ,  A61B10/00

CPC classification number: A61B5/0071 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/01 ,  A61B5/445 ,  A61B5/4519 ,  A61B5/72 ,  A61B5/742 ,  A61B10/00 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/0221 ,  Y02A90/26

Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.

公开(公告)号：US10106545B2

公开(公告)日：2018-10-23

申请号：US15434275

申请日：2017-02-16

Applicant: University Health Network

Inventor： Yong Liu ,  Heinz W. Pauls ,  Radoslaw Laufer ,  Sze-Wan Li ,  Peter Brent Sampson ,  Miklos Feher ,  Grace Ng ,  Narendra Kumar B. Patel ,  Yunhui Lang

IPC: C07D487/04

Abstract: The present teachings provide a compound represented by structural formula (I-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20180193361A1

公开(公告)日：2018-07-12

申请号：US15563392

申请日：2016-04-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Daniel Aaron WINER ,  Shawn Michael WINER ,  Sue Yu-Sue TSAI ,  Helen LUCK

IPC: A61K31/606 ,  A61P3/10 ,  A61K31/635 ,  A61K31/196

CPC classification number: A61K31/606 ,  A61K31/196 ,  A61K31/60 ,  A61K31/635 ,  A61P3/10

Abstract: A method of treating high blood glucose levels is disclosed. The method includes administering gut anti-inflammatory agents such as mesalamine (5-aminosalicylic acid), sulfasalazine, asacol, delzicol, pentasa, lialda, apriso, olsalazine, balsalazide and GED-0507-34, or pharmaceutically acceptable salts, solvates, or esters of any of the foregoing

公开(公告)号：US20180153938A1

公开(公告)日：2018-06-07

申请号：US15571593

申请日：2015-11-24

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Armand KEATING ,  Brent Allen WILLIAMS ,  Xing-Hua WANG

IPC: A61K35/17 ,  A61K39/395 ,  C12N5/0783 ,  A61P35/02

CPC classification number: A61K35/17 ,  A61K39/395 ,  A61K2039/505 ,  A61P35/02 ,  C07K16/2803 ,  C07K2317/732 ,  C12N5/0646

Abstract: Treatment of cancer in a patient comprises administering to the patient an effective amount of an antibody and an effective amount of NK cells, wherein the antibody binds an antigen on the surface of the NK cells and the antibody binds to an Fc receptor on a cell of the cancer. Anticancer activity is via resultant killing action of the NK cell on the cancer cell now binding the antibody via R-ADCC.