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公开(公告)号：US20220108461A1
公开(公告)日：2022-04-07
申请号：US17423597
申请日：2020-01-17
Applicant: University Health Network
Inventor： Ralph S. DACOSTA , Kathryn OTTOLINO-PERRY , Christopher GIBSON
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of target such as a tumor or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号：US20220082500A1
公开(公告)日：2022-03-17
申请号：US17423572
申请日：2020-01-17
Applicant: University Health Network
Inventor： Ralph S. DACOSTA , Kathryn OTTOLINO-PERRY , Christopher GIBSON , Nayana Thalanki ANANTHA , Cristiana O'BRIEN
Abstract: A tissue phantom is disclosed. The tissue phantom includes a first portion having the optical properties of healthy tissue and a second portion having the optical properties of cancerous tissue. Additionally, a method of calibrating an optical instrument is disclosed. The method includes illuminating a tissue phantom with excitation light from the optical instrument, detecting optical emissions emitted by the tissue phantom in response to illumination with the excitation light, and calibrating the optical instrument based upon the detected fluorescence.
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公开(公告)号：US20180325377A1
公开(公告)日：2018-11-15
申请号：US16027775
申请日：2018-07-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. DACOSTA , Brian C. WILSON , Kai ZHANG
CPC classification number: A61B5/0071 , A61B5/0042 , A61B5/0059 , A61B5/01 , A61B5/445 , A61B5/4519 , A61B5/72 , A61B5/742 , A61B10/00 , G01N21/6408 , G01N21/6456 , G01N21/6486 , G01N2021/6421 , G01N2021/6471 , G01N2201/0221 , Y02A90/26
Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.
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