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公开(公告)号：US20190105026A1
公开(公告)日：2019-04-11
申请号：US16154388
申请日：2018-10-08
Applicant: University of Iowa Research Foundation
Inventor： Evgeny Arshava
Abstract: A hand-held tool is provided for retraction of internal organs during transhiatal mediastinal surgery. The tool includes a handle and a blade extending forwardly from the handle. The blade has an acute end extending rearwardly and then curves forwardly and upwardly to form an open mouth for receiving the organ.
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82.发明申请公开(公告)号：US20190102918A1
公开(公告)日：2019-04-04
申请号：US16087419
申请日：2017-03-23
Applicant: University of Iowa Research Foundation
Inventor： Wenxiang Cong , Ye Yangbo , Ge Wang , Shuwei Mao , Yingmei Wang
Abstract: The disclosed apparatus, systems and methods relate to a framelet-based iterative algorithm for polychromatic CT which can reconstruct two components using a single scan. The algorithm can have various steps including a scaled-gradient descent step of constant or variant step sizes; a non-negativity step; a soft thresholding step; and a color reconstruction step.
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公开(公告)号：US10190137B2
公开(公告)日：2019-01-29
申请号：US15825616
申请日：2017-11-29
Applicant: EDITAS MEDICINE, INC. , THE BROAD INSTITUTE, INC. , THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Feng Zhang , Deborah Palestrant , Beverly Davidson , Jordi Mata-Fink , Edgardo Rodriguez , Alexis Borisy
Abstract: Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
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84.发明申请公开(公告)号：US20190002309A1
公开(公告)日：2019-01-03
申请号：US16023808
申请日：2018-06-29
Inventor： David CWIERTNY , Nosang MYUNG , Katherine T. PETER , Gene Francis PARKIN
IPC: C02F1/28 , B01D39/16 , D04H3/007 , D01F1/10 , D01F6/18 , C02F1/50 , B01J20/26 , B01J20/02 , B01J20/28
Abstract: A method is disclosed for synthesizing nanofilters for water treatment. The method includes: dispersing an active binding agent in an organic solvent solution to create a suspension of the active binding agent and the solution of the solvent; dissolving an organic polymer resin and an anionic surfactant in the suspension of the active binding agent and the solvent solution to create a sol gel; and electrospinning the sol gel to form electrospun nanofiber composites with embedded, surface-active nanoparticles.
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公开(公告)号：US20180296559A1
公开(公告)日：2018-10-18
申请号：US15724361
申请日：2017-10-04
Applicant: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： David A. STOLTZ , Daniel COOK
IPC: A61K31/506 , A61K9/00 , A61K45/06 , A61P11/00
Abstract: The present disclosure is directed to compositions and methods for treating airway smooth muscle dysfunction in a subject. The compounds target the tyrosine protein kinase 2 beta. A particular dysfunction is asthma, including cystic fibrosis-induced asthma.
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Patent Agency Ranking
公开(公告)号：US20180289725A1
公开(公告)日：2018-10-11
申请号：US16003184
申请日：2018-06-08
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventor： Christopher M. ADAMS , Michael C. DYLE , Michael WELSH
IPC: A61K31/58 , A23K20/121 , C07J53/00 , A61K45/06 , A23L33/10 , C12Q1/6883
Abstract: In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20180282702A1
公开(公告)日：2018-10-04
申请号：US15822956
申请日：2017-11-27
Inventor： Ziying Yan , John F. Engelhardt , Jianming Qiu
IPC: C12N7/00
Abstract: The invention provides an isolated chimeric virus comprising bocavirus capsid protein and a recombinant adeno-associated viral (AAV) genome, an isolated rBoV comprising human bocavirus capsid protein and a recombinant BoV genome, and uses therefor.
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公开(公告)号：US20180271783A1
公开(公告)日：2018-09-27
申请号：US15977858
申请日：2018-05-11
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Paul B. McCray , Patrick L. Sinn
CPC classification number: A61K9/0073 , A61K9/0043 , A61K48/005 , A61K48/0075 , A61K48/0083 , C07K2319/01 , C12N2740/15043 , C12N2740/15045 , C12N2810/6009 , C12N2810/6018 , C12N2810/6081
Abstract: The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.
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公开(公告)号：US20180236105A1
公开(公告)日：2018-08-23
申请号：US15769931
申请日：2016-10-24
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Beverly L. Davidson , Yong Hong Chen , Luis Tecedor
CPC classification number: A61K48/0075 , A61K9/0085 , A61K31/5377 , A61K38/13 , A61K38/4813 , A61K48/005 , A61P25/28 , C07K14/015 , C12N7/00 , C12N9/485 , C12N2750/14143 , C12N2750/14171 , C12Y304/14009 , A61K2300/00
Abstract: The present disclosure provides methods of treating a lysosomal storage disorder in a mammal which method comprises administering AAV particles encoding a polypeptide directly to the central nervous system of the mammal in conjunction with administering at least two immunosuppressive agents. AAV particles may be delivered by direct injection into the brain, spinal cord, cerebral spinal fluid or a portion thereof.
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公开(公告)号：US20180228806A1
公开(公告)日：2018-08-16
申请号：US15906844
申请日：2018-02-27
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Justin L. Grobe , Mark K. Santillan , Donna Ann Santillan
IPC: A61K31/519 , A61K31/404 , A61K31/55 , G01N33/68 , A61K38/11 , G01N33/543 , A61K45/06 , A61K31/498 , A61K31/444
CPC classification number: A61K31/519 , A61K31/404 , A61K31/444 , A61K31/498 , A61K31/55 , A61K38/095 , A61K45/06 , C12Y304/11003 , G01N33/54386 , G01N33/689 , G01N2800/368
Abstract: Compositions and methods for treating preeclampsia in a subject in need thereof are disclosed.
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