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公开(公告)号：US20170319775A1
公开(公告)日：2017-11-09
申请号：US15656152
申请日：2017-07-21
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Katherine Radwanski
CPC classification number: A61M1/3681 , A61M1/30 , A61M1/3455 , A61M1/3496 , A61M1/3683 , A61M1/3686 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B04B11/02
Abstract: Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient. The processing set remains connected to the patient during the entire ECP treatment procedure and provides an online, sterile closed pathway between the separation chamber and the treatment chamber.
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公开(公告)号：US09744288B2
公开(公告)日：2017-08-29
申请号：US15189752
申请日：2016-06-22
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Katherine Radwanski
CPC classification number: A61M1/3681 , A61M1/30 , A61M1/3455 , A61M1/3496 , A61M1/3683 , A61M1/3686 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B04B11/02
Abstract: Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient. The processing set remains connected to the patient during the entire ECP treatment procedure and provides an online, sterile closed pathway between the separation chamber and the treatment chamber.
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公开(公告)号：US09713669B2
公开(公告)日：2017-07-25
申请号：US14140978
申请日：2013-12-26
Applicant: Fenwal, Inc.
Inventor： Christopher Wegener , Bret Olson , Kyungyoon Min
CPC classification number: A61M1/3496 , A61M1/26 , A61M1/262 , A61M1/265 , A61M1/3633 , A61M2205/3365 , B01D63/16 , B01D2315/02
Abstract: A method is provided for separating a suspension of cellular material comprising at least two differently-sized cell types using a spinning membrane separator. The method comprises selecting the cell type to be separated by passing through the membrane; determining a concentration of the selected cell type in the suspension; selecting an inlet flow rate for the suspension; selecting a rotational speed for the spinning membrane separator related to one or more of the concentration and relative size of the selected cell type in the suspension; rotating the spinning membrane separator at the selected rotational speed so that the selected cell type tends to migrate to regions of the shear field adjacent the porous membrane; and flowing the suspension through the spinning membrane separator.
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公开(公告)号：US09409128B2
公开(公告)日：2016-08-09
申请号：US13835127
申请日：2013-03-15
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Katherine Radwanski
CPC classification number: A01N1/0226 , A01N1/0273 , A61M1/0209 , A61M1/0236 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , B01D61/28 , B01D61/32
Abstract: Methods and systems for processing and conditioning red blood cells are disclosed. The methods and systems may be used to make a readily transfusible red blood cell product with reduced plasma. In general, the plasma content of the supernatant of the red blood cell product is no greater than about 15%. The red blood cell products are prepared using the disclosed methods and systems remain transfusible for up to 42 days.
Abstract translation: 公开了用于处理和调节红细胞的方法和系统。 该方法和系统可用于制备具有降低血浆的容易输入的红细胞产品。 通常，红细胞产物的上清液的血浆含量不大于约15％。 使用所公开的方法制备红细胞产品，并且系统保持转导达42天。
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公开(公告)号：US09388383B2
公开(公告)日：2016-07-12
申请号：US14422032
申请日：2013-03-11
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener , William H. Cork
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
Abstract translation: 提供使用纺丝膜分离器收集双倍体积的红细胞的方法和系统，通过该方法和系统从供体中取出第一量的全血; 第一量的全血流入纺丝膜分离器; 其中它被分成第一量的红细胞和第一量的血浆。 然后将第一数量的红细胞和第一量的血浆流入相应的收集容器，并且将第一量的等离子体的至少一部分返回给供体。 从供体排出的第二量全血，然后使用纺丝膜分离器分离成第二量的红细胞和第二量的血浆。 然后将第二数量的红细胞和第二量的血浆流到相应的收集容器，并且将第二量的等离子体的至少一部分返回给供体。
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Patent Agency Ranking
公开(公告)号：US20160151549A1
公开(公告)日：2016-06-02
申请号：US15014177
申请日：2016-02-03
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Christopher Wegener , Kyungyoon Min
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting leukoreduced red blood cells employing a spinning membrane separator including a housing having an upper end region and a lower end region in an operating position with a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing. The method and system provide for flowing additive solution into the whole blood inlet of the housing to prime the separator; flowing whole blood into the whole blood inlet of the housing separating red blood cells from the whole blood; flowing separated red blood cells out of the red blood cell outlet of the housing; combining the separated red blood cells with additive solution: passing the separated red blood cells and additive solution combination through a leukoreduction filter; and collecting the filtered red blood cells and additive solution.
Abstract translation: 一种使用纺丝膜分离器收集白血球减少的红细胞的方法和系统，所述方法和系统包括在壳体的上端区域中具有红细胞出口的操作位置的上端区域和下端区域的壳体和全血 入口在壳体的下端区域。 该方法和系统将流动的添加剂溶液提供到壳体的整个血液入口中以引导分离器; 将全血流入分离红细胞与全血的壳体的全血入口; 流出分离的红细胞从房屋的红细胞出口; 将分离的红细胞与添加剂溶液组合：将分离的红细胞和添加剂溶液组合通过白细胞减少过滤器; 并收集过滤的红细胞和添加剂溶液。
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公开(公告)号：US09327296B2
公开(公告)日：2016-05-03
申请号：US13750232
申请日：2013-01-25
Applicant: Fenwal, Inc.
Inventor： Gregory G. Pieper , Salvatore Manzella, Jr. , Brian C. Case , Steven R. Katz , Kyungyoon Min
CPC classification number: B04B7/08 , B04B5/0442 , B04B2005/045
Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
Abstract translation: 流体分离室被提供用于围绕流体处理系统中的轴线旋转。 流体分离室可以设置有第一和第二级，第一和第二级位于不同的轴向位置。 在另一个实施例中，至少一个级可以围绕旋转轴设置有不均匀的外径，其可以限定大致螺旋状的轮廓或用于分馏流体或流体部件的不同轮廓。 一个或多个阶段也可以具有沿轴线的变化的外径。 腔室的轮廓可以由腔室本身（在刚性室的情况下）或由相关联的固定装置或离心机装置（在柔性腔室的情况下）提供。
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公开(公告)号：US09284529B2
公开(公告)日：2016-03-15
申请号：US14625121
申请日：2015-02-18
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Christopher Wegener , Kyungyoon Min
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting leukoreduced red blood cells employing a spinning membrane separator including a housing having an upper end region and a lower end region in an operating position with a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing. The method and system provide for flowing additive solution into the whole blood inlet of the housing to prime the separator; flowing whole blood into the whole blood inlet of the housing; separating red blood cells from the whole blood; flowing separated red blood cells out of the red blood cell outlet of the housing; combining the separated red blood cells with additive solution; passing the separated red blood cells and additive solution combination through a leukoreduction filter; and collecting the filtered red blood cells and additive solution.
Abstract translation: 一种使用纺丝膜分离器收集白血球减少的红细胞的方法和系统，所述方法和系统包括在壳体的上端区域中具有红细胞出口的操作位置的上端区域和下端区域的壳体，以及全血 入口在壳体的下端区域。 该方法和系统将流动的添加剂溶液提供到壳体的整个血液入口中以引导分离器; 将全血流入住房的全血入口; 从全血中分离红细胞; 流出分离的红细胞从房屋的红细胞出口; 将分离的红细胞与添加剂溶液结合; 通过白细胞减少过滤器分离红细胞和添加剂溶液组合; 并收集过滤的红细胞和添加剂溶液。
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89.发明申请Systems and Methods for Achieving Target Post-Procedure Fraction of Cells Remaining, Hematocrit, and Blood Volume During a Therapeutic Red Blood Cell Exchange Procedure With Optional Isovolemic Hemodilution 有权在治疗性红细胞交换程序中使用任选的异戊二烯血液稀释法实现靶细胞剩余，血细胞比容和血液体积分数的系统和方法公开(公告)号：US20130267884A1
公开(公告)日：2013-10-10
申请号：US13840113
申请日：2013-03-15
Applicant: FENWAL, INC.
Inventor： Daniel R. Boggs , Kyungyoon Min , Lan T. Nguyen , John T. Foley , Brian Case
IPC: A61M1/38
CPC classification number: A61M1/3455 , A61M1/342 , A61M1/3437 , A61M1/3458 , A61M1/3496 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2205/3334 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/207 , G06F19/00
Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
Abstract translation: 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。
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公开(公告)号：US20130196840A1
公开(公告)日：2013-08-01
申请号：US13750232
申请日：2013-01-25
Applicant: Fenwal, Inc.
Inventor： Gregory G. Pieper , Salvatore Manzella, JR. , Brian C. Case , Steven R. Katz , Kyungyoon Min
IPC: B04B7/08
CPC classification number: B04B7/08 , B04B5/0442 , B04B2005/045
Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
Abstract translation: 流体分离室被提供用于围绕流体处理系统中的轴线旋转。 流体分离室可以设置有第一和第二级，第一和第二级位于不同的轴向位置。 在另一个实施例中，至少一个级可以围绕旋转轴设置有不均匀的外径，其可以限定大致螺旋状的轮廓或用于分馏流体或流体部件的不同轮廓。 一个或多个阶段也可以具有沿轴线的变化的外径。 腔室的轮廓可以由腔室本身（在刚性室的情况下）或由相关联的固定装置或离心机装置（在柔性腔室的情况下）提供。
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