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    Modular fiber optic fluorometer and method of use thereof
    82.
    发明授权
    Modular fiber optic fluorometer and method of use thereof 失效
    模块化光纤荧光计及其使用方法

    公开(公告)号：US5994707A

    公开(公告)日：1999-11-30

    申请号：US819050

    申请日：1997-03-18

    Applicant: Edgar A. Mendoza ,  James E. Sorenson ,  Robert A. Lieberman ,  Thomas C. Forrester

    Inventor： Edgar A. Mendoza ,  James E. Sorenson ,  Robert A. Lieberman ,  Thomas C. Forrester

    IPC: G01N21/64

    CPC classification number: G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/086

    Abstract: A low cost portable fiber optic fluorometer is packaged as a personal computer peripheral and is based on interchangeable modules. One embodiment of the fluorometer comprises an excitation source, a detector, a signal processor, frequency source, wavelength selector, and an optical interface. The optical interface is exclusively fiber optic-based, thereby simplifying optical alignment and reducing the cost of the fluorometer. In another embodiment, the excitation source is an inexpensive monochromatic excitation source. In this case, the monochromatic excitation source and the first wavelength selector are preferably removable and replaceable, so that the fluorometer is advantageously able to generate different excitation wavelengths and detect different emission wavelengths. A fluorescence measurement method comprises the steps of generating an excitation signal; transmitting the excitation signal to a system under study which, in response, generates an emission signal; and detecting both the excitation signal and the emission signal with the fluorometer, and then using the detected excitation signal as a reference signal to calibrate the fluorometer and to nullify distortion errors in the emission signal. The use of the excitation signal as a reference signal provides an advantageously simple way to calibrate the fluorometer and to nullify distortion errors in the emission signal. An alternative method allows the precise shapes of the emission signal and the excitation signal to be profiled. The fluorometry method and apparatus can both advantageously be used for performing both direct fluorescence lifetime measurements and for performing phase fluorometry.

    Abstract translation: 低成本便携式光纤荧光计作为个人计算机外围设备封装，并且基于可互换的模块。 荧光计的一个实施例包括激发源，检测器，信号处理器，频率源，波长选择器和光学接口。 光接口仅仅是基于光纤的，从而简化了光学对准并降低了荧光计的成本。 在另一个实施例中，激发源是便宜的单色激发源。 在这种情况下，单色激发源和第一波长选择器优选是可移除和可更换的，使得荧光计有利地能够产生不同的激发波长并检测不同的发射波长。 荧光测量方法包括产生激励信号的步骤; 将激励信号传输到被研究的系统，其响应地产生发射信号; 并用荧光计检测激发信号和发射信号，然后使用检测到的激发信号作为参考信号来校准荧光计，并消除发射信号中的失真误差。 使用激励信号作为参考信号提供校准荧光计并消除发射信号中的失真误差的有利的简单方式。 替代方法允许对发射信号和激励信号的精确形状进行轮廓分析。 荧光测定方法和装置可以有利地用于进行直接荧光寿命测量和用于进行相位荧光测定。

    Integrated optical compensating refractometer apparatus
    83.
    发明授权
    Integrated optical compensating refractometer apparatus 失效
    集成光补偿折射仪

    公开(公告)号：US5377008A

    公开(公告)日：1994-12-27

    申请号：US862494

    申请日：1992-04-02

    Applicant: Richard W. Ridgway ,  Anthony A. Boiarski ,  Van E. Wood ,  James R. Busch

    Inventor： Richard W. Ridgway ,  Anthony A. Boiarski ,  Van E. Wood ,  James R. Busch

    IPC: G01N21/27 ,  G01J9/02 ,  G01N21/45 ,  G01N21/77 ,  G01N33/543 ,  G02B6/12 ,  G02B6/122 ,  G01B9/02

    CPC classification number: G01N21/7703 ,  G01N21/45 ,  G01N33/54373 ,  G02B6/122 ,  G01J2009/023 ,  G01N2021/1751 ,  G01N21/648 ,  G01N2201/0245 ,  G01N2201/0873 ,  G02B2006/12097 ,  G02B2006/12138 ,  G02B2006/12159

    Abstract: An apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a compensation path that includes the sensing region to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. In one embodiment a ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a curved or serpentine path configured so that nonspecific sensing effects are compensated.

    Abstract translation: 一种用于对流体进行免疫测定的装置，光被引导到光学传感器，其中光被传送到可在其暴露于流体的感测区域中的折射率的可更换光学装置。 光的一部分经由包括感测区域的补偿路径传送到第一检测器。 光的另一部分经由包括感测区域的感测路径传输到另一个检测器。 在一个实施例中，比例设备接收每个检测器的输出，并且响应于输出的比率提供信号。 可替换的光学器件通常包括一对定向耦合布置中的一个通道波导，或一个干涉仪布置中的一对通道波导，或者具有曲线或蛇形路径的脊波导，其配置为使得非特定的感测效果得到补偿。

    Integrated optical directional-coupling refractometer apparatus
    84.
    发明授权
    Integrated optical directional-coupling refractometer apparatus 失效
    集成光学方向联轴器压力计装置

    公开(公告)号：US5173747A

    公开(公告)日：1992-12-22

    申请号：US585438

    申请日：1990-09-20

    Applicant: Anthony A. Boiarski ,  Richard W. Ridgway

    Inventor： Anthony A. Boiarski ,  Richard W. Ridgway

    IPC: G01N21/27 ,  G01J9/02 ,  G01N21/45 ,  G01N21/77 ,  G01N33/543 ,  G02B6/12 ,  G02B6/122

    CPC classification number: G01N21/45 ,  G01N21/7703 ,  G01N33/54373 ,  G02B6/122 ,  G01J2009/023 ,  G01N2021/1751 ,  G01N21/648 ,  G01N2201/0245 ,  G01N2201/0873 ,  G02B2006/12097 ,  G02B2006/12138 ,  G02B2006/12159

    Abstract: In apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a reference path to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. A ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a serpentine path.

    Abstract translation: 在用于免疫测定流体的装置中，光被引导到光学传感器，其中光被传送到可替换的光学装置，该装置响应于暴露于流体的感测区域中的折射率。 光的一部分经由参考路径被传送到第一检测器。 光的另一部分经由包括感测区域的感测路径传输到另一个检测器。 比较装置接收每个检测器的输出，并提供响应输出比的信号。 可更换光学器件通常包括一对定向耦合布置中的通道波导，或干涉仪布置中的一对通道波导或具有蛇形路径的脊波导。

    Atomic absorption spectrometer
    85.
    发明授权
    Atomic absorption spectrometer 失效
    原子吸收光谱仪

    公开(公告)号：US4989975A

    公开(公告)日：1991-02-05

    申请号：US439404

    申请日：1989-11-16

    Applicant: Carl G. Dencks ,  Gunther Roedel ,  Klaus P. Rogasch

    Inventor： Carl G. Dencks ,  Gunther Roedel ,  Klaus P. Rogasch

    IPC: G01N21/31 ,  G01N21/72 ,  G01N21/74

    CPC classification number: G01N21/3103 ,  G01N21/74 ,  G01N2021/3111 ,  G01N2021/3118 ,  G01N2021/745 ,  G01N21/72 ,  G01N2201/0245

    Abstract: In an atomic absorption spectrometer with an atomizing device (190) and a line emitting light source (16), an optical system (22,28 . . . ) for generating a measuring light beam (18), and a photo-electrical detector (38), which are arranged in a housing (10) which forms a sample cavity (12) accessible from the outside and which is passed through by a measuring light beam (18) and into which different atomizing devices can be optionally inserted, the atomizing device (190) with the specific components (104,124,126) is assembled to form an insert unit (100) in which the atomizing device (190) in the form of a graphite furnace has a well-defined position relatively to the insert unit (100) and which in turn can be inserted into the sample cavity (12) in a well-defined position to provide an entirely functioning atomic absorption spectrometer.

    Abstract translation: PCT No.PCT / EP89 / 00258 Sec。 371日期：一九八九年十一月十六日 102（e）日期1989年11月16日PCT申请日1989年3月13日PCT Pub。 公开号WO89 / 08831 日本1989年9月21日。在具有雾化装置（190）和发射光源（16）的原子吸收光谱仪中，用于产生测量光束（18）的光学系统（22,28 ...） 和光电检测器（38），其布置在壳体（10）中，壳体（10）形成从外部可接近并通过测量光束（18）通过的样品腔（12），并且不同的雾化装置 可以可选地插入，具有特定部件（104,124,126）的雾化装置（190）被组装以形成插入单元（100），其中石墨炉形式的雾化装置（190）具有相对明确的位置 到所述插入单元（100），并且所述插入单元又可以在明确定义的位置插入到所述样品腔（12）中，以提供完全功能的原子吸收光谱仪。

    NITROUS OXIDE SENSOR
    86.
    发明公开
    NITROUS OXIDE SENSOR 审中-公开

    公开(公告)号：US20240159664A1

    公开(公告)日：2024-05-16

    申请号：US18282458

    申请日：2022-03-16

    Applicant: Medclair AB

    Inventor： István Szabó ,  Jerker Sundling ,  Tomas Nyberg

    IPC: G01N21/3518 ,  G08B21/12

    CPC classification number: G01N21/3518 ,  G08B21/12 ,  G01N2201/0235 ,  G01N2201/0245

    Abstract: The present invention relates to a gas sensor (100) comprising a measurement chamber (102) for measuring presence of a first gas, the first gas being nitrous oxide (N2O) and an optical source (103) for emitting radiation in the measurement chamber (102). The sensor also comprises a radiation detector (104) sensitive to radiation emitted by the optical source (103), the radiation being detected by the radiation detector (104) following passage through the measurement chamber (102). A diffusion layer (131) is configured to allow diffusion of ambient gas into and out from the measurement chamber (102), and the diffusion layer (131) comprises means (133) for preventing diffusion of carbon dioxide (CO2) in the ambient gas into the measurement chamber (102). The invention also relates a nitrous oxide detector comprising such a gas sensor, and a method for determining presence of nitrous oxide in the ambience.

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