公开(公告)号：US08470794B2

公开(公告)日：2013-06-25

申请号：US12681160

申请日：2008-10-01

Applicant: Sumedha D. Jayasena ,  Susan Swift

Inventor： Sumedha D. Jayasena ,  Susan Swift

IPC: C12N15/11

CPC classification number: C23C4/02 ,  C23C4/01 ,  C23C4/08 ,  C23C4/134 ,  H01J35/10 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/1204

Abstract: Methods and compositions relating to nucleic acids targeting certain miRNA molecules are disclosed. The nucleic acids are useful, for example, in methods of increasing the expression and/or secretion of EPO and treating various disease states including anemia, hemophilia, and/or sickle cell disease.

Abstract translation: 公开了涉及靶向某些miRNA分子的核酸的方法和组合物。 核酸可用于例如增加EPO的表达和/或分泌并治疗各种疾病状态（包括贫血，血友病和/或镰状细胞病）的方法。

公开(公告)号：US08243884B2

公开(公告)日：2012-08-14

申请号：US12680427

申请日：2008-09-25

Applicant: Peter Rödhammer ,  Wolfgang Glatz ,  Bernhard Tabernig ,  Hannes Wagner

Inventor： Peter Rödhammer ,  Wolfgang Glatz ,  Bernhard Tabernig ,  Hannes Wagner

IPC: H01J35/10

CPC classification number: H01J35/08 ,  C22C26/00 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/086 ,  H01J2235/1204 ,  H01J2235/1291 ,  H01J2235/1295

Abstract: An X-ray anode includes a coating and a support body. In addition to a strength-imparting region, the support body has a region formed of a diamond-metal composite material. The diamond-metal composite material is formed of 40 to 90% by volume diamond particles, 10 to 60% by volume binding phase(s) formed of a metal or an alloy of the metals of the group consisting of Cu, Ag, Al and at least one carbide of the elements of the group consisting of Tr, Zr, Hf, V, Nb, Ta, Cr, Mo, W, B, and Si. The highly heat-conductive region can be form-lockingly connected at the back to a heat-dissipating region, for example formed of Cu or a Cu alloy. The X-ray anode has improved heat dissipation and lower composite stress.

Abstract translation: X射线阳极包括涂层和支撑体。 除了强度赋予区域之外，支撑体具有由金刚石 - 金属复合材料形成的区域。 金刚石 - 金属复合材料由金刚石颗粒为40至90体积％，金属或由Cu，Ag，Al组成的组中的金属或合金形成的10至60体积％的结合相形成， 由Tr，Zr，Hf，V，Nb，Ta，Cr，Mo，W，B和Si组成的组的元素中的至少一种碳化物。 高导热区域可以在背面形成锁定连接到例如由Cu或Cu合金形成的散热区域。 X射线阳极具有改善的散热和较低的复合应力。

公开(公告)号：US08116432B2

公开(公告)日：2012-02-14

申请号：US11737932

申请日：2007-04-20

Applicant: Gregory Alan Steinlage ,  Michael Hebert

Inventor： Gregory Alan Steinlage ,  Michael Hebert

IPC: H01J35/10 ,  H01J35/08

CPC classification number: H01J35/10 ,  H01J2235/083

Abstract: A target for generating x-rays includes a target substrate comprising at least one layer of a target material, a track comprising at least one layer of a track material, the track configured to generate x-rays from high-energy electrons impinging thereon, and a braze joint attaching the target substrate to the track.

Abstract translation: 用于产生X射线的目标包括包括至少一层靶材料的目标衬底，轨道包括轨道材料的至少一层，轨道被配置为从其上撞击的高能电子产生X射线，以及 将目标衬底附接到轨道的钎焊接头。

公开(公告)号：US20120014510A1

公开(公告)日：2012-01-19

申请号：US13054066

申请日：2009-07-15

Applicant: Edward James Morton ,  Russell David Luggar ,  Martin Hunt

Inventor： Edward James Morton ,  Russell David Luggar ,  Martin Hunt

IPC: H01J35/12

CPC classification number: H01J35/12 ,  H01J35/08 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/086 ,  H01J2235/1204 ,  H01J2235/1262

Abstract: An anode for an X-ray tube includes at least one thermally conductive anode segment in contact with a rigid support member and cooling means arranged to cool the anode. The anode may further include a plurality of anode segments aligned end to end, each in contact with the support member.

Abstract translation: 用于X射线管的阳极包括与刚性支撑构件接触的至少一个导热阳极段和布置成冷却阳极的冷却装置。 阳极可以进一步包括多个阳极段，其端对端排列，每个阳极段与支撑构件接触。

公开(公告)号：US07910051B2

公开(公告)日：2011-03-22

申请号：US11935099

申请日：2007-11-05

Applicant: Stefan Zimmermann ,  Steve A. Miller ,  Prabhat Kumar ,  Mark Gaydos

Inventor： Stefan Zimmermann ,  Steve A. Miller ,  Prabhat Kumar ,  Mark Gaydos

IPC: C22F3/02 ,  C23C14/00 ,  B05D1/12

CPC classification number: H01J35/108 ,  B22F7/08 ,  C23C14/3414 ,  C23C24/04 ,  H01J35/08 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/085 ,  Y10T29/4902

Abstract: In various embodiments, large-area sputtering targets are formed by providing a plurality of sputtering targets each comprising a backing plate and a refractory metal layer disposed thereon, and spray depositing a refractory metal powder on an interface between the sputtering targets, the refractory metal powder consisting essentially of the same metal as each refractory metal layer, thereby joining the refractory metal layers of the sputtering targets.

Abstract translation: 在各种实施例中，通过提供多个溅射靶来形成大面积溅射靶，每个溅射靶包括背板和设置在其上的难熔金属层，并且在溅射靶之间的界面上喷射沉积难熔金属粉末，难熔金属粉末 基本上由与每个难熔金属层相同的金属组成，由此连接溅射靶的难熔金属层。

公开(公告)号：US20100316193A1

公开(公告)日：2010-12-16

申请号：US12680427

申请日：2008-09-25

Applicant: Peter Rödhammer ,  Wolfgang Glatz ,  Bernhard Tabernig ,  Hannes Wagner

Inventor： Peter Rödhammer ,  Wolfgang Glatz ,  Bernhard Tabernig ,  Hannes Wagner

IPC: H01J35/08

CPC classification number: H01J35/08 ,  C22C26/00 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/086 ,  H01J2235/1204 ,  H01J2235/1291 ,  H01J2235/1295

Abstract: An X-ray anode includes a coating and a support body. In addition to a strength-imparting region, the support body has a region formed of a diamond-metal composite material. The diamond-metal composite material is formed of 40 to 90% by volume diamond particles, 10 to 60% by volume binding phase(s) formed of a metal or an alloy of the metals of the group consisting of Cu, Ag, Al and at least one carbide of the elements of the group consisting of Tr, Zr, Hf, V, Nb, Ta, Cr, Mo, W, B, and Si. The highly heat-conductive region can be form-lockingly connected at the back to a heat-dissipating region, for example formed of Cu or a Cu alloy. The X-ray anode has improved heat dissipation and lower composite stress.

Abstract translation: X射线阳极包括涂层和支撑体。 除了强度赋予区域之外，支撑体具有由金刚石 - 金属复合材料形成的区域。 金刚石 - 金属复合材料由金刚石颗粒为40至90体积％，由金属或由Cu，Ag，Al组成的组中的金属或合金形成的10至60体积％的结合相形成， 由Tr，Zr，Hf，V，Nb，Ta，Cr，Mo，W，B和Si组成的组的元素中的至少一种碳化物。 高导热区域可以在背面形成锁定连接到例如由Cu或Cu合金形成的散热区域。 X射线阳极具有改善的散热和较低的复合应力。

公开(公告)号：US07558377B2

公开(公告)日：2009-07-07

申请号：US11840303

申请日：2007-08-17

Applicant: Joerg Freudenberger ,  Eberhard Lenz

Inventor： Joerg Freudenberger ,  Eberhard Lenz

IPC: H01J35/08

CPC classification number: H01J35/105 ,  H01J35/12 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/086 ,  H01J2235/1204 ,  H01J2235/1295

Abstract: An x-ray anode has an emission layer and a carrier with carrier material to support the emission layer. The carrier material is a metallized carbon fiber material with a portion in which the fibers are specifically directed. A high heat dissipation from the emission layer and a coefficient of heat expansion of the carrier that is advantageous for bonding with the emission layer are achieved.

Abstract translation: x射线阳极具有发射层和具有载体材料的载体以支持发射层。 载体材料是金属化碳纤维材料，其中纤维特别指向的部分。 实现了有利于与发射层结合的发射层的高散热性和载体的热膨胀系数。

公开(公告)号：US20080258068A1

公开(公告)日：2008-10-23

申请号：US12165500

申请日：2008-06-30

Applicant: Hendrik F. Hamann ,  Yves Martin ,  Theodore G. van Kessel ,  Hemantha K. Wickramasinghe

Inventor： Hendrik F. Hamann ,  Yves Martin ,  Theodore G. van Kessel ,  Hemantha K. Wickramasinghe

IPC: H01J37/06 ,  H01J35/02 ,  G01T1/24

CPC classification number: H01J35/08 ,  G21K7/00 ,  H01J2235/083 ,  H01J2235/086

Abstract: A device for generating an x-ray point source includes a target, and an electron source for producing electrons which intersect with the target to generate an x-ray point source having a size which is confined by a dimension of the target.

Abstract translation: 用于产生x射线点源的装置包括靶，以及用于产生与靶相交的电子的电子源，以产生具有被靶的尺寸限制的尺寸的x射线点源。

公开(公告)号：US20080216602A1

公开(公告)日：2008-09-11

申请号：US11935099

申请日：2007-11-05

Applicant: Stefan Zimmermann ,  Uwe Papp ,  Hans Keller ,  Steven A. Miller ,  Prabhat Kumar ,  Mark Gaydos ,  Rong-Chen Richard Wu

Inventor： Stefan Zimmermann ,  Uwe Papp ,  Hans Keller ,  Steven A. Miller ,  Prabhat Kumar ,  Mark Gaydos ,  Rong-Chen Richard Wu

IPC: C23C14/34 ,  C22C5/00 ,  C22C27/04 ,  C22C27/00 ,  C22C14/00 ,  C22C9/00 ,  C23C24/04 ,  H01J35/00

CPC classification number: H01J35/108 ,  B22F7/08 ,  C23C14/3414 ,  C23C24/04 ,  H01J35/08 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/085 ,  Y10T29/4902

Abstract: Disclosed is a process for the reprocessing or production of a sputter target or an X-ray anode wherein a gas flow forms a gas/powder mixture with a powder of a material chosen from the group consisting of niobium, tantalum, tungsten, molybdenum, titanium, zirconium, mixtures of two or more thereof and alloys thereof with at least two thereof or with other metals, the powder has a particle size of 0.5 to 150 μm, wherein a supersonic speed is imparted to the gas flow and the jet of supersonic speed is directed on to the surface of the object to be reprocessed or produced.

Abstract translation: 公开了一种用于再处理或生产溅射靶或X射线阳极的方法，其中气流与选自铌，钽，钨，钼，钛的材料的粉末形成气体/粉末混合物 锆，其两种或多种的混合物及其至少两种或其中的金属或其它金属的混合物，所述粉末的粒度为0.5-150μm，其中超音速被赋予气流和超音速射流 被引导到待再处理或生产的物体的表面上。

公开(公告)号：US07186022B2

公开(公告)日：2007-03-06

申请号：US10467944

申请日：2003-01-30

Applicant: Harry K. Charles, Jr. ,  Thomas J. Beck

Inventor： Harry K. Charles, Jr. ,  Thomas J. Beck

IPC: H01J35/10 ,  H01J35/12

CPC classification number: H05G1/02 ,  H01J35/08 ,  H01J35/108 ,  H01J35/12 ,  H01J35/18 ,  H01J35/30 ,  H01J2235/081 ,  H01J2235/083 ,  H01J2235/087 ,  H01J2235/1204 ,  H01J2235/1262 ,  H01J2235/186 ,  H05G1/025

Abstract: An x-ray tube and method of operating include a vacuum chamber vessel and a source of an electron beam inside the vacuum chamber vessel. A target disposed inside the vacuum chamber vessel includes a substrate and one or more deposits attached to the substrate. Each different deposit includes an atomic element having a different atomic number. The x-ray tube also includes a means for directing the electron beam to a selectable deposit of multiple deposits. The substrate material can be selected with better vacuum sustaining strength, x-ray transparency, melting point, and thermal conductivity than a deposit. The substrate may be cooled by an integrated cooling system. The x-ray tube allows a selectable x-ray frequency to be produced with enhanced economy of power, reduced moving parts, and reduced size. For improved bone mass applications, one of the deposits has a k-fluorescence energy less than about 53 thousand electron volts.

Abstract translation: X射线管和操作方法包括在真空室容器内的真空室容器和电子束源。 设置在真空室容器内部的靶包括基底和附着到基底的一个或多个沉积物。 每个不同的沉积物包括具有不同原子序数的原子元素。 X射线管还包括用于将电子束引导到可选择沉积多个沉积物的装置。 可以选择具有比沉积物更好的真空维持强度，x射线透明度，熔点和导热性的基底材料。 衬底可以通过集成冷却系统来冷却。 X射线管允许以增强的功率经济性，减少的运动部件和减小的尺寸来产生可选择的x射线频率。 对于改进的骨量应用，沉积物中的一种具有小于约53000电子伏特的k-荧光能量。