公开(公告)号：US20250134955A1

公开(公告)日：2025-05-01

申请号：US19004325

申请日：2024-12-29

Applicant: Aston University

Inventor： Michael Tisdale ,  Steven Russell

IPC: A61K38/17 ,  A61K9/00 ,  A61K31/138 ,  A61K45/06 ,  A61K47/56

Abstract: Formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the like by targeted administration to the oesphagus of a subject of Zn-α2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as β adrenergin receptor agonists, β adrenergin receptor antagonists, and/or glycemic control agents.

公开(公告)号：US20240301022A1

公开(公告)日：2024-09-12

申请号：US18598878

申请日：2024-03-07

Applicant: Aston University

Inventor： Michael J. Tisdale ,  Steven T. Russell

IPC: C07K14/47 ,  A23L33/17 ,  A61K9/00 ,  A61K31/137 ,  A61K31/138 ,  A61K38/17 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K47/61

CPC classification number: C07K14/473 ,  A23L33/17 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0053 ,  A61K31/137 ,  A61K31/138 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/1741 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K47/61

Abstract: The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as cachexia, hypoglycemia, obesity, diabetes, and the like by administering Zn-α2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as β adrenergin receptor agonists, β adrenergin receptor antagonists, and/or glycemic control agents.

公开(公告)号：US20240131033A1

公开(公告)日：2024-04-25

申请号：US18277718

申请日：2022-02-04

Applicant: ASTON UNIVERSITY

Inventor： Roslyn Mary Bill ,  Stuart David Greenhill ,  Luke David Southan

IPC: A61K31/5415 ,  A61K31/46 ,  A61P25/00

CPC classification number: A61K31/5415 ,  A61K31/46 ,  A61P25/00

Abstract: This invention relates to a method of treating damage to the central nervous system, comprising administering a pharmaceutically-effective amount of a CCR5 antagonist, and a pharmaceutically effective amount of an AQP4 antagonist, or pharmaceutically acceptable salts thereof.

公开(公告)号：US11717531B2

公开(公告)日：2023-08-08

申请号：US16847499

申请日：2020-04-13

Applicant: ASTON UNIVERSITY

Inventor： Meng Cai ,  Keqinq Wang ,  Asif Ahmed

IPC: A61K31/713 ,  C12N15/11 ,  C12Q1/6883 ,  G01N33/50

CPC classification number: A61K31/713 ,  C12N15/111 ,  C12Q1/6883 ,  G01N33/50 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/30 ,  C12Q2600/118 ,  C12Q2600/178

Abstract: The invention provides a method of treating preeclampsia, fetal growth restriction (FGR or IUGR), obesity in pregnancy, post-partum cardiomyopathy (heart failure in mothers), cancer and diabetic retinopathy, cardiomyopathy, myocardial infarction, wet microdegeneration and other disorders where angiogenesis is aberrant either diminished or exacerbated, comprising modulating the activity of micro RNA (miRNA). Also provided are an MiRNA modulator or a combination thereof or functional fragments or homologues thereof for use in the treatment of preeclampsia, fetal growth restriction, obesity in pregnancy, cancer, and diabetic retinopathy, cardiomyocyte infarction, wet microdegeneration as well as other disorder where angiogenesis is aberrant either diminished or exacerbated. Methods of modulating angiogenesis and pharmaceutical compositions using miR-122, miR-374b or inhibitors of miR-152 or miR195 are also provided together with methods of diagnosis using the miRNAs.

公开(公告)号：US11311646B2

公开(公告)日：2022-04-26

申请号：US16464561

申请日：2017-11-29

Applicant: ASTON UNIVERSITY

Inventor： Richard Martin

IPC: A61L27/10 ,  C03C3/062 ,  C03C3/097 ,  C03C4/00

Abstract: A bioactive glass composition for use in treating bone cancer includes 0.5-10 mol % gallium oxide or 1.0-20 mol % gallium nitrate/halide; 25 to 75 mol % silicon dioxide; 10 to 30 mol % calcium oxide and/or strontium oxide; up to 30 mol % sodium oxide; and up to 15 mol % phosphorous pentoxide. It may further comprise magnesium and/or potassium oxide. The bioactive glass composition may be positioned within a patient's bone post-surgery to promote apatite formation and to release gallium ions having a toxic effect on any remaining cancerous cells.

公开(公告)号：US20200038354A1

公开(公告)日：2020-02-06

申请号：US16516597

申请日：2019-07-19

Applicant: Aston University

Inventor： Asif AHMED ,  Keqing WANG ,  Shakil AHMAD

IPC: A61K31/198 ,  G01N33/68

Abstract: The invention provides a method of diagnosis or prognosis of preeclampsia in a pregnant subject, comprising providing a sample from a pregnant subject and measuring the ratio between the amount of (a) one or both of sFlt-1 and PlGF, and (b) one or both of a breakdown product of heme and a breakdown product of arginine, in the sample. Also described are assay kits and a computer adapted for use in the method. Also described is a method of treating preeclampsia, comprising administering a pharmaceutically effective amount of L-arginine and/or citrulline and an inhibitor of arginase or pharmaceutically acceptable salts thereof. Also described is a method of treating cancer, comprising treating a subject with a therapeutically effective amount of an anti-VEGF compound, L-arginine and an arginase inhibitor.

公开(公告)号：US10195220B2

公开(公告)日：2019-02-05

申请号：US14771285

申请日：2014-03-03

Applicant: Aston University

Inventor： Asif Ahmed ,  Keqing Wang

IPC: A61K31/675 ,  A61K31/095

Abstract: The application describes Hydrogen Sulphide (H2S), or a (H2S) generating compound or compound capable of stimulating H2S production in a pregnant subject, for use in the treatment of pre-eclampsia (PE) or fetal growth restriction.

公开(公告)号：US10193619B2

公开(公告)日：2019-01-29

申请号：US15762386

申请日：2016-09-22

Applicant: ASTON UNIVERSITY

Inventor： Filipe Ferreira ,  Andrew Ellis ,  Naoise Mac-Suibhne ,  Christian Sanchez-Costa

IPC: H04J14/04 ,  H04B10/077 ,  H04Q11/00

Abstract: A method of compensating for crosstalk in a mode division multiplexing passive optical network using a technique of transmitter-side crosstalk pre-compensation, performed at the Central Office, in which a downlink reference signal such as a training sequence or pilot signal is retrieved at the transmitter without being influenced by crosstalk effects on its uplink transmission. An uplink reference signal is transmitted in a quasi-single mode transmission along the optical fiber, and a plurality of optical signals input to transmission multiplexer are adapted based on the uplink reference signal to pre-compensate for crosstalk.

公开(公告)号：US20180100755A1

公开(公告)日：2018-04-12

申请号：US15726771

申请日：2017-10-06

Applicant: AIRBUS OPERATIONS LIMITED ,  ASTON UNIVERSITY

Inventor： Alessio CIPULLO ,  Neil Thomson GORDON ,  Kaiming ZHOU

IPC: G01F23/292

CPC classification number: G01F23/2928 ,  G01B9/02091 ,  G01B11/0608 ,  G01F23/0092 ,  G01F23/292

Abstract: A method of measuring a height of a fuel in an aircraft fuel tank (21) b including illuminating the fuel in the aircraft fuel tank and detecting reflected light from the fuel. Optical coherence tomography is used to determine the height of a surface of fuel in the fuel tank. An apparatus (30) is used to measure a height of a surface of fuel in an aircraft fuel tank, and an aircraft fuel tank system with a fuel tank and an apparatus for measuring a height of a surface of fuel in the aircraft fuel tank.

公开(公告)号：US20170320906A1

公开(公告)日：2017-11-09

申请号：US15528475

申请日：2015-11-26

Applicant: Aston University

Inventor： Daniel Lee Rathbone ,  Tony Worthington ,  Sahar Al-Malaika ,  Matthew Justin Hird ,  Alexandria Rose Quayle

IPC: C07J43/00 ,  C07J41/00 ,  C07J9/00 ,  A61K45/06 ,  A61K31/58 ,  C08F293/00 ,  A61K31/575

Abstract: The invention relates to compounds, compositions and polymers comprising a first component adapted to promote germination of Clostridium difficile (C.diff) and a second component which acts as an antimicrobial agent. Said compounds, compositions and polymers are useful for destroying C.diff where conventional antimicrobial agents are unsuccessful. The compositions can be formulated as coating or materials which actively destroy C.diff which come into contact with it. The germination promotion is induced by bile salts. The invention also relates to the use of such materials as a treatment for C.diff associated diseases and toxic megacolon.