公开(公告)号：US08792989B2

公开(公告)日：2014-07-29

申请号：US12582990

申请日：2009-10-21

Applicant: Orlando Guntinas-Lichius ,  Andreas Müller ,  Werner Lindenthaler

Inventor： Orlando Guntinas-Lichius ,  Andreas Müller ,  Werner Lindenthaler

IPC: A61N1/18

CPC classification number: A61N1/36067 ,  A61B5/0488 ,  A61N1/0526 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36003 ,  A61N1/36139 ,  A61N1/36185

Abstract: A method for stimulating facial nerves in a subject with synkinetic reinnervated muscles includes providing an electrode, having a plurality of contacts, in a parotic region of the subject's face, stimulating each of the contacts separately, identifying one or more contacts from the plurality of contacts that cause one or more nerve branches to activate a desired facial muscle, and selecting the identified contacts to stimulate the one or more nerve branches. The system includes an electrode having a plurality of contacts for placement in a parotic region of the subject's face and a processor in communication with the electrode. The processor has program code for stimulating each of the contacts separately, for identifying one or more contacts from the plurality of contacts that cause one or more nerve branches to activate a desired facial muscle, and for selecting the identified contacts to stimulate the one or more nerve branches.

Abstract translation: 用于刺激具有再动力增强肌肉的受试者中的面神经的方法包括在对象的脸部的不利区域中提供具有多个触点的电极，分别刺激每个触点，从多个触点识别一个或多个触点 导致一个或多个神经分支激活所需的面部肌肉，以及选择所识别的接触以刺激所述一个或多个神经分支。 该系统包括具有多个触点的电极，用于放置在被检者的脸部的不便的区域中，以及处理器与电极连通。 所述处理器具有用于分别刺激每个触点的程序代码，用于识别来自所述多个触点中的一个或多个触点，所述触点引起一个或多个神经分支激活期望的面部肌肉，并且用于选择所识别的触点以刺激所述一个或多个 神经分支。

公开(公告)号：US08709410B2

公开(公告)日：2014-04-29

申请号：US12999045

申请日：2009-06-16

Applicant: Carsten Korth ,  Lothar Stitz ,  Benjamin Petsch ,  Andreas Müller-Schiffmann ,  Sirik Rutger Leliveld

Inventor： Carsten Korth ,  Lothar Stitz ,  Benjamin Petsch ,  Andreas Müller-Schiffmann ,  Sirik Rutger Leliveld

IPC: A61K39/395

Abstract: The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.

公开(公告)号：US08430860B2

公开(公告)日：2013-04-30

申请号：US11848108

申请日：2007-08-30

Applicant: Werner Lindenthaler ,  Andreas Müller

Inventor： Werner Lindenthaler ,  Andreas Müller

IPC: A61M31/00

CPC classification number: A61B17/3468 ,  A61B10/04 ,  A61B17/00234 ,  A61B17/24 ,  A61B2017/003 ,  A61B2017/00991 ,  A61B2017/3443 ,  A61B2018/1475 ,  A61N1/0517 ,  A61N1/0519 ,  A61N1/0548 ,  A61N1/3601 ,  A61N1/3611

Abstract: A system and method of introducing interface elements for interfacing with laryngeal structures of a subject such as for diagnosis or treatment of a laryngeal impairment is presented. Illustrative embodiments include generating a tunnel in geographical relation to the lateral wing of the cricoid cartilage of the subject and introducing at least one interface element via the tunnel for interfacing with at least one laryngeal structure of the subject.

Abstract translation: 提出了一种引入用于与受试者的喉结构接口的界面元件的系统和方法，例如用于诊断或治疗喉部损伤。 示例性实施例包括产生与受试者的环状软骨的侧翼的地理关系的隧道，并且经由隧道引入至少一个界面元件，用于与受试者的至少一个喉结构接口。

公开(公告)号：US08380313B2

公开(公告)日：2013-02-19

申请号：US13073975

申请日：2011-03-28

Applicant: Andreas Müller ,  Gerhard Foster ,  Rudolf Hagen

Inventor： Andreas Müller ,  Gerhard Foster ,  Rudolf Hagen

IPC: A61N1/06

CPC classification number: A61B17/3468 ,  A61B10/04 ,  A61B17/00234 ,  A61B17/24 ,  A61B2017/003 ,  A61B2017/00991 ,  A61B2017/3443 ,  A61B2018/1475 ,  A61N1/0517 ,  A61N1/0519 ,  A61N1/0548 ,  A61N1/3601 ,  A61N1/3611

Abstract: A minimally invasive method of introducing an interface element to interface with laryngeal structures of a subject includes forming a subperichondral tunnel on an outside of a cricoid cartilage arch and through the cricoid cartilage arch towards a cricothyroid joint to form an insertion route. The method also includes inserting a hollow needle into the insertion route to a posterior space of a cricoid cartilage plate of the subject, positioning at least one interface element along the insertion route for interfacing with the laryngeal structures of the subject, and retracting the hollow needle back along the insertion route.

Abstract translation: 将界面元素引入到与受试者的喉结构相接触的微创方法包括在环状软骨弓的外侧形成次级软骨层隧道，并通过环状软骨弓朝向甲状腺关节形成插入路线。 该方法还包括将空心针插入到被检体的环状软骨板的后部空间的插入路径中，沿着插入路线定位至少一个界面元件，用于与受检者的喉结构接口，并且缩回中空针 沿插入路线。

公开(公告)号：US08066282B2

公开(公告)日：2011-11-29

申请号：US12501781

申请日：2009-07-13

Applicant: Andreas Müller ,  Burkhard Wolf

Inventor： Andreas Müller ,  Burkhard Wolf

IPC: B65H5/02

CPC classification number: B65H9/002 ,  B65H5/021 ,  B65H5/224 ,  B65H11/005 ,  B65H2220/09 ,  B65H2404/5311 ,  B65H2406/32 ,  B65H2406/322

Abstract: An apparatus for feeding and aligning sheets which are fed to a processing machine, e.g. a printing machine, includes at least two parallel transporting belts which, on a side directed toward the sheet, subject the sheet to different retaining forces, in such a way that the retaining force in outer peripheral regions is greater than in an inner region located therebetween. The transporting belts can be activated individually in dependence on the position of the sheet, and they can therefore align the sheet in its transporting direction and obliquely thereto.

Abstract translation: 用于进给和对准被供给到加工机器的片材的设备，例如， 一种印刷机，包括至少两个平行的传送带，所述至少两个平行的传送带在朝向片材的一侧上以不同的保持力对待该片材，使得外周区域中的保持力大于位于其间的内部区域 。 输送带可以根据片材的位置而单独启动，因此它们可以在其输送方向上与其倾斜地对准片材。

公开(公告)号：US07860355B2

公开(公告)日：2010-12-28

申请号：US12382595

申请日：2009-03-19

Applicant: Hakon Mikkelsen ,  Andreas Müller ,  Patric Henzi

Inventor： Hakon Mikkelsen ,  Andreas Müller ,  Patric Henzi

IPC: G02B6/00

CPC classification number: G01N21/552

Abstract: An ATR-probe including: a housing having a media opening; a radiation guiding body closing the media opening and having two planparallel surfaces, between which light can be guided by means of total reflection. A section of a first planparallel surface bordered by a sealing ring can be contacted through the media opening with a medium to be measured. Transmission light conductors and receiving light conductors in the housing, wherein light is guided from the transmission light conductors, through the radiation guiding body, into the receiving light conductors; and wherein adjoining the first planparallel surface are first and second deflection surfaces, on which, respectively, light coupled into the radiation guiding body and light to be coupled out are deflected by total reflection, so that the light can be guided between the planparallel surfaces by means of total reflection. The light is not collimated, and the effective area of the transmission light conductors is smaller than the effective area of the receiving light conductors.

Abstract translation: 一种ATR探针，包括：具有介质开口的壳体; 辐射引导体关闭介质开口并具有两个平行的平面，在该表面之间可以通过全反射来引导光。 由密封环邻接的第一平行平面的一部分可以通过介质开口与要测量的介质接触。 传输光导体和壳体中的接收光导体，其中光从传输光导体被引导通过辐射引导体，进入接收光导体; 并且其中邻接所述第一平行平行表面是第一和第二偏转表面，其上分别耦合到所述辐射引导体中的光和待耦合出的光通过全反射而偏转，使得所述光可以在所述平行平行表面之间被引导， 全反射的手段 光不被准直，传输光导体的有效面积小于接收光导体的有效面积。

公开(公告)号：US07837192B2

公开(公告)日：2010-11-23

申请号：US12405386

申请日：2009-03-17

Applicant: Andreas Müller ,  Burkhard Wolf

Inventor： Andreas Müller ,  Burkhard Wolf

IPC: B65H9/04

CPC classification number: B65H9/06 ,  B41F21/12 ,  B65H2403/512 ,  B65H2801/21

Abstract: An apparatus for continuous alignment of sheets which are fed to a processing machine, includes an alignment cylinder on which stops for the sheets are disposed. The stops are pivoted out of the periphery of the alignment cylinder and moved on a translational movement path during an alignment phase.

Abstract translation: 供给到加工机器的纸张的连续对准的装置包括对准筒，其上设置有片材的止挡部。 止动件在对准圆筒的周边枢转并且在对准阶段期间在平移运动路径上移动。

公开(公告)号：US20100007082A1

公开(公告)日：2010-01-14

申请号：US12501781

申请日：2009-07-13

Applicant: Andreas Müller ,  Burkhard Wolf

Inventor： Andreas Müller ,  Burkhard Wolf

IPC: B65H9/14 ,  B65H9/00 ,  B65H7/02

CPC classification number: B65H9/002 ,  B65H5/021 ,  B65H5/224 ,  B65H11/005 ,  B65H2220/09 ,  B65H2404/5311 ,  B65H2406/32 ,  B65H2406/322

Abstract: An apparatus for feeding and aligning sheets which are fed to a processing machine, e.g. a printing machine, includes at least two parallel transporting belts which, on a side directed toward the sheet, subject the sheet to different retaining forces, in such a way that the retaining force in outer peripheral regions is greater than in an inner region located therebetween. The transporting belts can be activated individually in dependence on the position of the sheet, and they can therefore align the sheet in its transporting direction and obliquely thereto.

Abstract translation: 用于进给和对准被供给到加工机器的片材的设备，例如， 一种印刷机，包括至少两个平行的传送带，所述至少两个平行的传送带在朝向片材的一侧上以不同的保持力对待该片材，使得外周区域中的保持力大于位于其间的内部区域 。 输送带可以根据片材的位置而单独启动，因此它们可以在其输送方向上与其倾斜地对准片材。

公开(公告)号：US06899742B2

公开(公告)日：2005-05-31

申请号：US10444931

申请日：2003-05-23

Applicant: Andreas Müller

Inventor： Andreas Müller

IPC: B01D46/00 ,  B01D46/04 ,  B01D46/10 ,  B01D46/42 ,  B01D46/52 ,  B01D29/68

CPC classification number: B01D46/10 ,  B01D46/0068 ,  B01D46/42 ,  B01D46/521

Abstract: In a cleaning arrangement for a filter element disposed in a gas flow channel and including a plurality of filter pockets, a flow blocking element arranged adjacent the filter element at the downstream side thereof and having openings movable with the flow blocking element into alignment with the various filter pockets for controlling a back-flushing gas flow through the filter element, the blocking element is an elastic thin-walled structure provided with at least one opening of a shape corresponding in cross-section to the filter pocket openings and means are provided for generating in the area downstream of the blocking element a gas pressure for back-flushing the filter element pockets in succession as the blocking element with the at least one opening is moved across the filter element.

Abstract translation: 在用于设置在气体流动通道中并且包括多个过滤器袋的过滤元件的清洁装置中，流动阻挡元件在其下游侧邻近过滤元件布置，并且具有可与流动阻挡元件一起移动的开口， 用于控制通过过滤器元件的反冲洗气流的过滤器袋，所述阻塞元件是弹性薄壁结构，其设置有至少一个开口，该开口具有与过滤器袋开口的横截面对应的形状，并且提供用于产生 在阻挡元件下游的区域中，当具有至少一个开口的阻挡元件移动穿过过滤元件时，连续地反冲洗过滤元件袋的气体压力。

公开(公告)号：US08852587B2

公开(公告)日：2014-10-07

申请号：US12999045

申请日：2009-06-16

Applicant: Carsten Korth ,  Lothar Stitz ,  Benjamin Petsch ,  Andreas Müller-Schiffmann ,  Sirik Rutger Leliveld

Inventor： Carsten Korth ,  Lothar Stitz ,  Benjamin Petsch ,  Andreas Müller-Schiffmann ,  Sirik Rutger Leliveld

IPC: A61K39/395

CPC classification number: C07K16/2872 ,  A61K2039/505 ,  C07K7/08 ,  C07K14/47 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622

Abstract: The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.

Abstract translation: 本发明涉及特异性识别朊病毒蛋白的抗体，抗体片段或其衍生物，其包含互补决定区（CDR），所述CDR的逆反式D-肽和/或抗独特型抗体，抗体片段 或其衍生物识别所述CDR。 本发明还涉及编码所述抗体，抗体片段或其衍生物的核酸分子以及产生特异性识别朊病毒蛋白的抗体，抗体片段或其衍生物的方法，其中识别朊病毒的特定结构域的抗体 产生蛋白质，从抗体中分离抗原特异性氨基酸序列，并产生识别所述抗原特异性氨基酸序列的抗独特型抗体，抗体片段或其衍生物。