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    Optical-based sensing devices
    3.
    发明申请
    Optical-based sensing devices 失效
    光传感器

    公开(公告)号：US20060231749A1

    公开(公告)日：2006-10-19

    申请号：US11106481

    申请日：2005-04-15

    Applicant: Arthur Colvin ,  Casey O'Connor ,  Andrew DeHennis

    Inventor： Arthur Colvin ,  Casey O'Connor ,  Andrew DeHennis

    IPC: H01J5/02

    CPC classification number: G01N21/645 ,  A61B5/0031 ,  A61B5/0084 ,  A61B5/07 ,  A61B5/6861 ,  A61B2560/0219 ,  G01N21/77 ,  G01N2021/7786

    Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.

    Abstract translation: 本发明提供一种用于检测分析物的存在或浓度的电光检测装置。 更具体地说，本发明涉及（但不是在所有情况下都必须限于）光学感测装置，其特征在于是完全独立的，具有平滑和圆形的长圆形，椭圆形或椭圆形（例如，豆 - 或药物胶囊形状）和允许将装置植入人体以便各种分析物的原位检测的尺寸。

    Optical-based sensing devices
    4.
    发明申请
    Optical-based sensing devices 有权

    公开(公告)号：US20060149143A1

    公开(公告)日：2006-07-06

    申请号：US11340523

    申请日：2006-01-27

    Applicant: Arthur Colvin

    Inventor： Arthur Colvin

    IPC: A61B5/00

    CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

    Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

    High performance fluorescent optical sensor
    6.
    发明申请
    High performance fluorescent optical sensor 有权

    公开(公告)号：US20050237518A1

    公开(公告)日：2005-10-27

    申请号：US11165129

    申请日：2005-06-24

    Applicant: Arthur Colvin ,  Steven Walters

    Inventor： Arthur Colvin ,  Steven Walters

    IPC: G01N21/64 ,  G01N21/77 ,  G01J1/42

    CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

    Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

    OPTICAL-BASED SENSING DEVICES
    9.
    发明申请
    OPTICAL-BASED SENSING DEVICES 有权
    光学传感器件

    公开(公告)号：US20080108885A1

    公开(公告)日：2008-05-08

    申请号：US11925272

    申请日：2007-10-26

    Applicant: Arthur Colvin

    Inventor： Arthur Colvin

    IPC: A61B5/00

    CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

    Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

    Abstract translation: 一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。 该传感器具有一个传感器体，其中嵌有辐射源。 源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。 优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。 这样的实施例优选地包括电源，例如电源。 电感器，其使用外部装置为辐射源供电，以及发射器，例如， 电感器，用于向外部拾取装置传输表示分析物水平的信号。

    Electro-optical sensing device with reference channel
    10.
    发明申请
    Electro-optical sensing device with reference channel 审中-公开
    具有参考通道的电光感测装置

    公开(公告)号：US20070059210A1

    公开(公告)日：2007-03-15

    申请号：US11595986

    申请日：2006-11-13

    Applicant: Arthur Colvin ,  Robert Lynn

    Inventor： Arthur Colvin ,  Robert Lynn

    IPC: G01N21/00

    CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/783 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2021/7796 ,  Y10T436/144444

    Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions. The indicator element used to measure the analyte in the external medium is preferably also covered, but in a manner that provides direct contact between the analyte and the indicator element.

    Abstract translation: 用于检测液体或气体介质中分析物的存在和浓度的电光检测装置包括一对指示元件，其被定位成接收来自辐射源的辐射并将辐射传输到一对感光元件。 指示剂元素各自包含具有响应于分析物存在的光学特性的指示剂分子; 然而，其中一个指示元件被分析物不可渗透的腔室覆盖，使得指示元件对室内的介质中分析物的存在不敏感，使得其可以用作参考以消除影响的环境和系统变量 两个指标元素。 该室优选地保持与参考指示元件接触的含分析物的流体，使得指示元件在名义上相同的条件下操作。 用于测量外部介质中的分析物的指示剂元素优选也被覆盖，但是以提供分析物与指示剂元件之间的直接接触的方式。

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