公开(公告)号：US20170121669A1

公开(公告)日：2017-05-04

申请号：US15406819

申请日：2017-01-16

Applicant: BIOCEP LTD.

Inventor： Aharon LAMISH ,  Ofer KLEIN

IPC: C12N1/02 ,  B03C1/28 ,  B03C1/033 ,  C12Q1/24 ,  C12M1/00

CPC classification number: C12N1/02 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/26 ,  C12M47/02 ,  C12Q1/24

Abstract: A magnetic separation system configured to separate with high qualitative and quantitative yield magnetized cells from cell mixtures, comprising at least one electromagnet structured to generate a magnetic field flux about a plurality of separation zones and sufficient to attract a majority of the magnetized cells in the mixture, and a pump to drive the cell mixture at a controlled flow rate through a tube disposed within the zones thereby separating a majority of the magnetized cells from the mixture. The system is particularly useful to retrieve rare cells from a fluid mixture of cells having low abundance of the rare cells relative to the rest of the cells while sustaining viability of the cells.

公开(公告)号：US09546392B2

公开(公告)日：2017-01-17

申请号：US14976895

申请日：2015-12-21

Applicant: BIOCEP LTD.

Inventor： Aharon Lamish ,  Ofer Klein

IPC: G01N30/00 ,  B01J19/08 ,  G01N31/00 ,  C12Q1/24 ,  B03C1/033 ,  B03C1/28 ,  C12M1/00 ,  C12N1/02

CPC classification number: C12N1/02 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/26 ,  C12M47/02 ,  C12Q1/24

Abstract: A magnetic separation system configured to separate with high qualitative and quantitative yield magnetized cells from cell mixtures, comprising at least one electromagnet structured to generate a magnetic field flux about a plurality of separation zones and sufficient to attract a majority of the magnetized cells in the mixture, and a pump to drive the cell mixture at a controlled flow rate through a tube disposed within the zones thereby separating a majority of the magnetized cells from the mixture. The system is particularly useful to retrieve rare cells from a fluid mixture of cells having low abundance of the rare cells relative to the rest of the cells while sustaining viability of the cells.

Abstract translation: 一种磁分离系统，其被配置为以高定性和定量的方式从细胞混合物中分离产生磁化细胞，其包括至少一个电磁体，其被构造为在多个分离区周围产生磁场通量并且足以吸引混合物中的大部分磁化细胞 以及泵，其以受控的流速通过设置在所述区域内的管驱动细胞混合物，从而将大部分磁化细胞与混合物分离。 该系统特别可用于从维持细胞活力的细胞中相对于细胞的其余部分从具有低丰度稀有细胞的细胞的流体混合物中检索稀有细胞。

公开(公告)号：US20160108454A1

公开(公告)日：2016-04-21

申请号：US14976895

申请日：2015-12-21

Applicant: BIOCEP LTD.

Inventor： Aharon LAMISH ,  Ofer KLEIN

IPC: C12Q1/24

CPC classification number: C12N1/02 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/26 ,  C12M47/02 ,  C12Q1/24

Abstract: A magnetic separation system configured to separate with high qualitative and quantitative yield magnetized cells from cell mixtures, comprising at least one electromagnet structured to generate a magnetic field flux about a plurality of separation zones and sufficient to attract a majority of the magnetized cells in the mixture, and a pump to drive the cell mixture at a controlled flow rate through a tube disposed within the zones thereby separating a majority of the magnetized cells from the mixture. The system is particularly useful to retrieve rare cells from a fluid mixture of cells having low abundance of the rare cells relative to the rest of the cells while sustaining viability of the cells.

Abstract translation: 一种磁分离系统，其被配置为以高定性和定量的方式从细胞混合物中分离产生磁化细胞，其包括至少一个电磁体，其被构造为在多个分离区周围产生磁场通量并且足以吸引混合物中的大部分磁化细胞 以及泵，其以受控的流速通过设置在所述区域内的管驱动细胞混合物，从而将大部分磁化细胞与混合物分离。 该系统特别可用于从维持细胞活力的细胞中相对于细胞的其余部分从具有低丰度稀有细胞的细胞的流体混合物中检索稀有细胞。