Systems And Methods For Simultaneous Detection And Identification Of Microorganisms Within A Fluid Sample

    公开(公告)号:US20200070146A1

    公开(公告)日:2020-03-05

    申请号:US16546805

    申请日:2019-08-21

    Inventor: Andrew Tomaras

    Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. Each sample containers holds a distinct microorganism-attracting substance and a portion of a fluid sample containing an unknown microorganism. Each distinct microorganism-attracting substance is configured to bind with a single type of microorganism. The unknown microorganism in the fluid sample binds with the distinct microorganism-attracting substance in a single sample container. The instrument incubates the microorganism in the single sample container and detects the presence of the microorganism in the single sample container to thereby simultaneously identify the unknown microorganism.

    Cuvette Device For Determining Antibacterial Susceptibility

    公开(公告)号:US20200249148A1

    公开(公告)日:2020-08-06

    申请号:US16781998

    申请日:2020-02-04

    Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly includes a unitary body made of a single type of transparent material. The unitary body includes a plurality of optical chambers for receiving the liquid sample, an entry side wall for allowing transmission of an input light beam into the respective liquid sample, and an exit side wall for transmitting a forward scatter signal caused by the particles within the respective liquid sample. Each of the plurality of optical chambers is separated by internal walls of the unitary body.

    Cuvette assembly having chambers for containing samples to be evaluated through optical measurement
    4.
    发明授权
    Cuvette assembly having chambers for containing samples to be evaluated through optical measurement 有权
    比色杯组件,其具有用于容纳通过光学测量评价的样品的室

    公开(公告)号:US09579648B2

    公开(公告)日:2017-02-28

    申请号:US14562304

    申请日:2014-12-05

    Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.

    Abstract translation: 本发明是一种用于光学测量多个液体样品中的颗粒的至少一种特性的比色皿组件。 所述比色杯组件包括具有内壁和外壁的主体,并且所述主体内的多个比色皿至少部分地由所述内壁限定。 多个试管中的每一个具有用于接收多个液体样品中的相应一个液体样品的液体输入室,用于接收由多个液体样品中的相应一个液体样品引起的各自过滤液体样品的光学室 通过过滤器。 每个光学室包括入口窗口,用于允许输入光束通过过滤的液体样品和用于传输由过滤液体样品内的颗粒引起的前向散射信号的出射窗口。

    Cuvette device for determining antibacterial susceptibility

    公开(公告)号:US11099121B2

    公开(公告)日:2021-08-24

    申请号:US16781998

    申请日:2020-02-04

    Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly includes a unitary body made of a single type of transparent material. The unitary body includes a plurality of optical chambers for receiving the liquid sample, an entry side wall for allowing transmission of an input light beam into the respective liquid sample, and an exit side wall for transmitting a forward scatter signal caused by the particles within the respective liquid sample. Each of the plurality of optical chambers is separated by internal walls of the unitary body.

    SYSTEMS AND METHODS USING BACTERIOPHAGE-MEDIATED LYSIS FOR DETECTION AND IDENTIFICATION OF MICROORGANISMS IN A FLUID SAMPLE

    公开(公告)号:US20200156057A1

    公开(公告)日:2020-05-21

    申请号:US16689793

    申请日:2019-11-20

    Inventor: Andrew Tomaras

    Abstract: An optical measurement instrument includes an optical cavity with a light source, a plurality of fluid containers, and an optical sensor. Each fluid container holds a test portion of a fluid sample containing an unknown microorganism, and either a distinct microorganism-attracting substance or a distinct growth-inhibiting substance. Each distinct microorganism-attracting or growth-inhibiting substance is configured to react with a single type of microorganism. The instrument incubates the test portions of the fluid sample within the fluid containers. When using microorganism-attracting substances, the presence of microorganism growth within one of the fluid containers simultaneously indicates the presence and identity of the unknown microorganism. When using growth-inhibiting substances, the absence of microorganism growth within one of the fluid containers simultaneously indicates the presence and identity of the unknown microorganism. The incubated test portions of the fluid sample can be compared to an incubated control portion of the fluid sample.

    Cuvette Assembly Having Chambers For Containing Samples To Be Evaluated Through Optical Measurement
    7.
    发明申请
    Cuvette Assembly Having Chambers For Containing Samples To Be Evaluated Through Optical Measurement 有权
    具有通过光学测量评估的包含样品室的比色杯组件

    公开(公告)号:US20150160119A1

    公开(公告)日:2015-06-11

    申请号:US14562304

    申请日:2014-12-05

    Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.

    Abstract translation: 本发明是一种用于光学测量多个液体样品中的颗粒的至少一种特性的比色皿组件。 所述比色杯组件包括具有内壁和外壁的主体,并且所述主体内的多个比色皿至少部分地由所述内壁限定。 多个试管中的每一个具有用于接收多个液体样品中的相应一个液体样品的液体输入室,用于接收由多个液体样品中的相应一个液体样品引起的各自过滤液体样品的光学室 通过过滤器。 每个光学室包括入口窗口,用于允许输入光束通过过滤的液体样品和用于传输由过滤液体样品内的颗粒引起的前向散射信号的出射窗口。

    Method and system for optical measurements of contained liquids having a free surface

    公开(公告)号:US10048198B2

    公开(公告)日:2018-08-14

    申请号:US14559286

    申请日:2014-12-03

    Abstract: The present invention is an optical measurement system for measuring a liquid sample within a well. The system comprises a light source configured to transmit light though the well, a detector configured to measure optical signals derived from the transmitted light, and a tunable optical element. The tunable optical element is positioned between the light source and the well. The tunable optical element is operable to shape the light to compensate for distortions induced by a surface of the liquid sample. The detector is preferably located below the well for receiving a forward scatter signal indicative of at least one characteristic of the particles within the liquid sample.

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