Systems And Methods For Simultaneous Detection And Identification Of Microorganisms Within A Fluid Sample

    公开(公告)号:US20200070146A1

    公开(公告)日:2020-03-05

    申请号:US16546805

    申请日:2019-08-21

    Inventor: Andrew Tomaras

    Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. Each sample containers holds a distinct microorganism-attracting substance and a portion of a fluid sample containing an unknown microorganism. Each distinct microorganism-attracting substance is configured to bind with a single type of microorganism. The unknown microorganism in the fluid sample binds with the distinct microorganism-attracting substance in a single sample container. The instrument incubates the microorganism in the single sample container and detects the presence of the microorganism in the single sample container to thereby simultaneously identify the unknown microorganism.

    SYSTEMS AND METHODS USING BACTERIOPHAGE-MEDIATED LYSIS FOR DETECTION AND IDENTIFICATION OF MICROORGANISMS IN A FLUID SAMPLE

    公开(公告)号:US20200156057A1

    公开(公告)日:2020-05-21

    申请号:US16689793

    申请日:2019-11-20

    Inventor: Andrew Tomaras

    Abstract: An optical measurement instrument includes an optical cavity with a light source, a plurality of fluid containers, and an optical sensor. Each fluid container holds a test portion of a fluid sample containing an unknown microorganism, and either a distinct microorganism-attracting substance or a distinct growth-inhibiting substance. Each distinct microorganism-attracting or growth-inhibiting substance is configured to react with a single type of microorganism. The instrument incubates the test portions of the fluid sample within the fluid containers. When using microorganism-attracting substances, the presence of microorganism growth within one of the fluid containers simultaneously indicates the presence and identity of the unknown microorganism. When using growth-inhibiting substances, the absence of microorganism growth within one of the fluid containers simultaneously indicates the presence and identity of the unknown microorganism. The incubated test portions of the fluid sample can be compared to an incubated control portion of the fluid sample.

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