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公开(公告)号：US20210156782A1
公开(公告)日：2021-05-27
申请号：US17048423
申请日：2019-04-17
Applicant: ChemoMetec A/S
Inventor： Johan Holm
Abstract: A method for characterizing object(s) in a sample includes collecting transmitted, refracted, scattered, diffracted, and/or emitted light from the sample. The collected light formed on a sensor surface includes at least a first and second image of the object(s). For at least the first and second image, the collected light is modulated asymmetrically differently, or for at least a third and fourth image focal plane positions are different, or for at least a fifth image the collected light is modulated in at least two places differently compared to the surroundings, or for at least a sixth and seventh image of the object(s), the collected light is modulated asymmetrically differently and focal planes of the sixth and seventh image have different positions. The images are processed to characterize the objects(s).
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公开(公告)号：US20180195958A1
公开(公告)日：2018-07-12
申请号：US15879696
申请日：2018-01-25
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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公开(公告)号：US10254223B2
公开(公告)日：2019-04-09
申请号：US15879696
申请日：2018-01-25
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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公开(公告)号：US09903819B2
公开(公告)日：2018-02-27
申请号：US14473020
申请日：2014-08-29
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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公开(公告)号：US20150053872A1
公开(公告)日：2015-02-26
申请号：US14473020
申请日：2014-08-29
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
IPC: G01N21/64
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
Abstract translation: 根据本发明的实施例，公开了一种从样品中检测荧光的装置。 所述装置包括：样品布置在其上的样品平面，至少包括用于照射样品的光源的激发光单元;以及检测单元，其至少包括具有至少100,000个活性检测元件的检测器，以检测来自 例子。
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Patent Agency Ranking
公开(公告)号：US11022539B2
公开(公告)日：2021-06-01
申请号：US16478194
申请日：2018-01-22
Applicant: ChemoMetec A/S
Inventor： Rune Troelsgaard Pedersen , Søren Kjærulff
Abstract: The current invention relates to the task of masking, i.e. determination of boundaries in an image of biological particles and/or elements or parts of biological particles in image cytometry. Methods for masking of a biological particle or element or region of a biological particle in a sample are provided which include staining a first element or region of the biological particle with a first fluorescent dye, staining a second element or region of the biological particle with a second fluorescent dye, recording an image of the fluorescent light signal emitted from the sample, and determining boundaries of the biological particle or element or region of the biological particle based on the fluorescent light signal in the image.
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公开(公告)号：US10921234B2
公开(公告)日：2021-02-16
申请号：US16502136
申请日：2019-07-03
Applicant: ChemoMetec A/S
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjærulff , Frans Ejner Ravn Hansen
Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field and optionally one or more sources of excitation light.
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公开(公告)号：US10458896B2
公开(公告)日：2019-10-29
申请号：US14893780
申请日：2014-05-28
Applicant: ChemoMetec A/S
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjaerulff , Frans Ejner Ravn Hansen
Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means (11, 112), a sample holder (100), a sample compartment (101), imaging means (120), collection means (121), light modulation means (122, 123), and detection means (130) with active detection elements (131).
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公开(公告)号：US20170261419A1
公开(公告)日：2017-09-14
申请号：US15532216
申请日：2015-12-03
Applicant: ChemoMetec A/S
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjaerulff , Frans Ejner Ravn Hansen
Abstract: The present invention relates to methods and systems for image cytometry analysis, in particular using light sources to be cooled. Thereby is provided optimal light conditions for image cytometry.
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公开(公告)号：US20240150820A1
公开(公告)日：2024-05-09
申请号：US18549611
申请日：2022-03-11
Applicant: CHEMOMETEC A/S
Inventor： Rune TROELSGAARD PEDERSEN , Søren KJÆRULFF , Alfred HANSWILLEMENKE
IPC: C12Q1/6844 , C12Q1/6834
CPC classification number: C12Q1/6846 , C12Q1/6834
Abstract: Detection and analysis of biological particles can provide useful information with respect to a wide range of applications. Those include but are not limited to analysis of disease markers in diagnostic samples, quantification of bacteria and/or viral particles in environmental samples, and detection of specific proteins in cell culture samples. The methods presented herein provide simple, rapid and reliable means of detecting and analyzing biological particles in a hydrogel, and are especially suitable for quantification of for example nucleic acids, viral particles, bacteria, yeast, animal cells, and proteins. The invention also relates to a kit of parts and to a system for detection and analysis of biological particles in a hydrogel.
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